IGF-I is abundantly expressed in the liver under the stimulation of GH. We showed previously that expression of hepatocyte nuclear factor (HNF)-3gamma, a liver-enriched transcription factor, was strongly stimulated by GH in bovine liver. In this study, we determined whether GH-increased HNF-3gamma m
Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.
Riffel AK1, Schuenemann E, Vyhlidal CA.
Molecular pharmacology.Mol Pharmacol.2009 Nov;76(5):1104-14. doi: 10.1124/mol.109.055699. Epub 2009 Aug 25.
Despite the established interindividual variability and ontogeny of the CYP3A enzymes, the most abundant phase I drug-metabolizing enzymes in human liver and intestine, the mechanisms that regulate basal expression remain poorly understood. Electrophoretic mobility shift assays using nuclear protein
Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.
Wiwi CA1, Waxman DJ.
The Journal of biological chemistry.J Biol Chem.2005 Feb 4;280(5):3259-68. Epub 2004 Nov 10.
Cytochrome P450 2A2 (CYP2A2) is an adult male-specific rat liver steroid hydroxylase whose sex-dependent expression is regulated at the transcriptional level by sexually dimorphic pituitary growth hormone (GH) secretory patterns. In contrast to CYP2C11 and other male-specific, plasma GH pulse-induci
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