WordNet
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
PrepTutorEJDIC
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
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- 1. 風疹 rubella
English Journal
- Comparison of automated measurements of electrocardiographic intervals and durations by computer-based algorithms of digital electrocardiographs.
- Kligfield P1, Badilini F2, Rowlandson I3, Xue J3, Clark E4, Devine B4, Macfarlane P4, de Bie J5, Mortara D5, Babaeizadeh S6, Gregg R6, Helfenbein ED6, Green CL7.Author information 1Division of Cardiology, Weill Cornell Medical College, New York, NY. Electronic address: pkligfi@med.cornell.edu.2AMPS-LLC, New York, NY.3GE Healthcare, Milwaukee, WI.4Glasgow Program, University of Glasgow, Glasgow, United Kingdom.5Mortara Instrument, Milwaukee, WI.6Philips Healthcare, Andover, MA.7Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.AbstractBACKGROUND AND PURPOSE: Automated measurements of electrocardiographic (ECG) intervals are widely used by clinicians for individual patient diagnosis and by investigators in population studies. We examined whether clinically significant systematic differences exist in ECG intervals measured by current generation digital electrocardiographs from different manufacturers and whether differences, if present, are dependent on the degree of abnormality of the selected ECGs.
- American heart journal.Am Heart J.2014 Feb;167(2):150-159.e1. doi: 10.1016/j.ahj.2013.10.004. Epub 2013 Oct 17.
- BACKGROUND AND PURPOSE: Automated measurements of electrocardiographic (ECG) intervals are widely used by clinicians for individual patient diagnosis and by investigators in population studies. We examined whether clinically significant systematic differences exist in ECG intervals measured by curre
- PMID 24439975
- snow white, a zebrafish model of Hermansky-Pudlak Syndrome type 5.
- Daly CM, Willer J, Gregg R, Gross JM.Author information Molecular, Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Texas 78722.AbstractHermansky-Pudlak Syndrome (HPS) is a set of genetically heterogeneous diseases caused by mutations in one of nine known HPS genes. HPS patients display oculocutaneous hypopigmentation and bleeding diathesis and, depending on the disease subtype, pulmonary fibrosis, congenital nystagmus, reduced visual acuity, and platelet aggregation deficiency. Mouse models for all known HPS subtypes have contributed greatly to our understanding of the disease, but many of the molecular and cellular mechanisms underlying HPS remain unknown. Here, we characterize ocular defects in the zebrafish (Danio rerio) mutant snow white (snw), which possesses a recessive, missense mutation in hps5 (hps5I76N). Melanosome biogenesis is disrupted in snw/hps5 mutants, resulting in hypopigmentation, a significant decrease in the number, size, and maturity of melanosomes, and the presence of ectopic multi-melanosome clusters throughout the mutant retina and choroid. snw/hps5I76N is the first Hps5 mutation identified within the N-terminal WD40 repeat protein-protein binding domain. Through in vitro coexpression assays, we demonstrate that Hps5I76N retains the ability to bind its protein complex partners, Hps3 and Hps6. Furthermore, while Hps5 and Hps6 stabilize each other's expression, this stabilization is disrupted by Hps5I76N. The snw/hps5I76N mutant provides a valuable resource for structure-function analyses of Hps5 and enables further elucidation of the molecular and cellular mechanisms underlying HPS.
- Genetics.Genetics.2013 Oct;195(2):481-94. doi: 10.1534/genetics.113.154898. Epub 2013 Jul 26.
- Hermansky-Pudlak Syndrome (HPS) is a set of genetically heterogeneous diseases caused by mutations in one of nine known HPS genes. HPS patients display oculocutaneous hypopigmentation and bleeding diathesis and, depending on the disease subtype, pulmonary fibrosis, congenital nystagmus, reduced visu
- PMID 23893484
- Molecular pathology of pancreatic neuroendocrine tumors.
- Chen M, Van Ness M, Guo Y, Gregg J.Author information Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, California, USA.AbstractPancreatic endocrine tumors (PETs) are rare neoplasms which account for 1% to 2% of all pancreatic malignancies. The diagnostic, grading and prognostic criteria for PETs have been controversial in surgical pathology and clinical medicine. The newly updated 2010 WHO classification introduced in clinical practice will give more insight into genetic and molecular changes related to PET subtypes. These neoplasms can be graded into 1 of 3 tiers, based on histologic characteristics in likeness to epithelial neuroendocrine tumors in other anatomic sites. Most PETs are sporadic, however, some of them, may occur as part of familial tumors (inherited syndromes) such as multiple endocrine neoplasia type 1 (MEN1 syndrome), von Hippel-Lindau disease (VHL), neurofibromatosis type 1 (NF-1), and tuberous sclerosis (TSC). In sporadic endocrine pancreatic tumors, losses of chromosome 1 and 11q as well as gain on 9q appear to be early events in the development of pancreatic tumors. Multiple genetic defects may accumulate with time and result in pancreatic neuroendocrine tumor progression and malignancy. Although PETs may be similar or identical in histologic appearance to neuroendocrine tumors of the gastrointestinal tract, differences in their underlying biology and likely differences in response to therapeutic agents suggest that they should be treated and investigated as a distinct entity. The correlation of PI3K/Akt/mTOR pathway in the pathogenesis of PETs has been reported, and clinical trials data of mTOR inhibitors is promising.
- Journal of gastrointestinal oncology.J Gastrointest Oncol.2012 Sep;3(3):182-8. doi: 10.3978/j.issn.2078-6891.2012.018.
- Pancreatic endocrine tumors (PETs) are rare neoplasms which account for 1% to 2% of all pancreatic malignancies. The diagnostic, grading and prognostic criteria for PETs have been controversial in surgical pathology and clinical medicine. The newly updated 2010 WHO classification introduced in clini
- PMID 22943010
Japanese Journal
- Pharmacologic Evidence for Abnormal Thalamocortical Functioning in GABA_A Receptor β3 Subunit-Deficient Mice, a Model of Angelman Syndrome
- Epilepsia : journal of the International League against Epilepsy 46(12), 1860-1870, 2005-12-01
- NAID 10017350996
- Copper deficiency masquerading as myelodysplastic syndrome
- Blood 100, 1493-1495, 2002
- NAID 30022494949
- 先天性風疹症候群とその臨床的診断
- 耳鼻と臨床 16(4), 211-220, 1970
- NAID 130004401726
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| リンク元 | 「先天性風疹症候群」 |
| 関連記事 | 「syndrome」 |
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