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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/16 22:07:25」(JST)

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G protein-coupled receptor kinase 5 is an enzyme that in humans is encoded by the GRK5 gene.^[1]^[2]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).^[2]

References

^ Kunapuli P, Benovic JL (Jul 1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family". Proc Natl Acad Sci U S A 90 (12): 5588–92. doi:10.1073/pnas.90.12.5588. PMC 46766. PMID 7685906.
^ ^a ^b "Entrez Gene: GRK5 G protein-coupled receptor kinase 5".

English Journal

Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.

Nicoletti G1, De Luca V2, Tarantino P3, Gagliardi M4, Iannello G4, Novellino F3, Morelli M5, Annesi G3, Quattrone A4.
Psychiatry research.Psychiatry Res.2015 Dec 30;230(3):975-7. doi: 10.1016/j.psychres.2015.11.026. Epub 2015 Nov 17.
The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293
PMID 26614013

Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.

Traynham CJ1, Cannavo A1, Zhou Y1, Vouga AG1, Woodall BP1, Hullmann J1, Ibetti J1, Gold JI1, Chuprun JK1, Gao E1, Koch WJ2.
Circulation research.Circ Res.2015 Dec 4;117(12):1001-12. doi: 10.1161/CIRCRESAHA.115.306961. Epub 2015 Oct 29.
RATIONALE: G protein-coupled receptor kinases (GRKs) are dynamic regulators of cellular signaling. GRK5 is highly expressed within myocardium and is upregulated in heart failure. Although GRK5 is a critical regulator of cardiac G protein-coupled receptor signaling, recent data has uncovered noncanon
PMID 26515328

Role of long purine stretches in controlling the expression of genes associated with neurological disorders.

Singh HN1, Rajeswari MR2.
Gene.Gene.2015 Nov 10;572(2):175-83. doi: 10.1016/j.gene.2015.07.007. Epub 2015 Jul 3.
Purine repeat sequences present in the human genome are known to act as hotspots for mutations leading to chromosomal imbalances. It is established that large purine repeats (PRs) form stable DNA triplex structure which can inhibit gene expression. Friedreich's ataxia (FRDA), the autosomal neurodege
PMID 26149656

Japanese Journal

心筋梗塞時のリモデリングにおけるGRK5の役割

黒瀬等
助成研究報告集 43, 3p, 2011
NAID 40020109362

Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes

Oyama Naotsugu,Urasawa Kazushi,Kaneta Satoshi,Sakai Hidetsugu,Saito Takahiko,Takagi Chika,Yoshida Ichiro,Kitabatake Akira,Tsutsui Hiroyuki
Circulation Journal 69(8), 987-990, 2005-07-20
… Methods and Results: Isoproterenol was injected into rats for 2 weeks, and then GRK5 mRNA was assessed by quantitative reverse transcriptase-palymerase chain reaction. … An enhanced expression of cardiac GRK5 mRNA was observed even after 4 weeks of recovery. … The isoproterenol-induced increased expression of GRK2 and GRK5 mRNA was equally observed in the heart and lymphocytes, and there was a close correlation between the heart and lymphocytes in the level of expression of each GRK mRNA. …
NAID 110002696214

カテコラミン投与中止後にも遷延するラット心筋GRK5 mRNAの発現の亢進

金田聡,浦澤一史,斎藤高彦,坂井英世,中野記嗣,高木康,北畠顕
臨床薬理 32(1), 25S, 2001-01-31
NAID 10011536130

Related Pictures

GRK5 promotes F-actin bundling and targets bundles to membrane structures to control Journal News: JBC: Structural studies of GRK5 抗CD45, Rat-Mono(IBL-3/16)抗体 | Anti-CD45, Rat-Mono(IBL-3/16) Antibody | フナコシ Oncotarget | The influence of two functional genetic variants of GRK5 on tau Anti-GRK5 抗体 (ab64943) | アブカム Frontiers | GRK5 – A Functional Bridge Between Cardiovascular and Neurodegenerative

★リンクテーブル★

リンク元	「G-protein-coupled receptor kinase 5」「Gタンパク質共役受容体キナーゼ5」
関連記事	「GRK」「GR」

「G-protein-coupled receptor kinase 5」

G protein-coupled receptor kinase 5
Identifiers
Symbols	GRK5 ; GPRK5
External IDs	OMIM: 600870 MGI: 109161 HomoloGene: 3879 ChEMBL: 5678 GeneCards: GRK5 Gene
EC number	2.7.11.16
Gene ontology
Molecular function	• protein serine/threonine kinase activity; • G-protein coupled receptor kinase activity; • protein kinase C binding; • protein binding; • ATP binding; • phospholipid binding;
Cellular component	• nucleus; • cytoplasm; • plasma membrane;
Biological process	• apoptotic process; • adenylate cyclase-modulating G-protein coupled receptor signaling pathway; • tachykinin receptor signaling pathway; • regulation of G-protein coupled receptor protein signaling pathway; • Wnt signaling pathway; • termination of G-protein coupled receptor signaling pathway; • negative regulation of apoptotic process; • protein autophosphorylation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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