Gタンパク質共役受容体キナーゼ3

関: G-protein-coupled receptor kinase 3

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/15 04:02:25」(JST)

wiki en

Beta-adrenergic receptor kinase 2 (beta-ARK-2) also known as G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in humans is encoded by the ADRBK2 gene.^[4]^[5]

Function

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.^[5]

Discovery

The beta adrenergic receptor kinase-2 was cloned from mice and rats in 1991^[6] and the human gene was cloned in 1993.^[7]

Clinical significance

gene linkage techniques were used to identify a mutation in the GRK3 gene as a possible cause of up to 10% of cases of bipolar disorder.^[8] Beta adrenergic receptor kinase-2 appears to affect dopamine metabolism. Subsequent studies, while noting that chromosome 22q12 may harbor a risk gene for schizophrenia, did not find that the gene coding for beta adrenergic receptor kinase-2 was linked to schizophrenia.^[9]

It has been associated with WHIM syndrome.^[10]

References

^ "Drugs that physically interact with Beta-adrenergic receptor kinase 2 view/edit references on wikidata".
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Calabrese G, Sallese M, Stornaiuolo A, Stuppia L, Palka G, De Blasi A (Feb 1995). "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286–8. doi:10.1006/geno.1994.1497. PMID 7695743.
^ ^a ^b "Entrez Gene: ADRBK2 adrenergic, beta, receptor kinase 2".
^ Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA, Gilbert DJ, Copeland NG, Caron MG, Lefkowitz RJ (August 1991). "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family". J. Biol. Chem. 266 (23): 14939–46. PMID 1869533.
^ Parruti G, Ambrosini G, Sallese M, De Blasi A (January 1993). "Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2". Biochem. Biophys. Res. Commun. 190 (2): 475–81. doi:10.1006/bbrc.1993.1072. PMID 8427589.
^ Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR (May 2003). "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder". Mol. Psychiatry. 8 (5): 546–57. doi:10.1038/sj.mp.4001268. PMID 12808434.
^ Yu SY, Takahashi S, Arinami T, Ohkubo T, Nemoto Y, Tanabe E, Fukura Y, Matsuura M, Han YH, Zhou RL, Shen YC, Matsushima E, Kojima T (February 2004). "Mutation screening and association study of the beta-adrenergic receptor kinase 2 gene in schizophrenia families". Psychiatry Res. 125 (2): 95–104. doi:10.1016/j.psychres.2003.12.003. PMID 15006433.
^ Balabanian K, Levoye A, Klemm L, et al. (March 2008). "Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling". J. Clin. Invest. 118 (3): 1074–84. doi:10.1172/JCI33187. PMC 2242619. PMID 18274673.

External links

Online version of the paper in Molecular Psychiatry
PubMed abstract
Report from sciencedaily.com

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
2. 収縮能障害による心不全におけるβブロッカー使用の理論的根拠および臨床試験 rationale for and clinical trials of beta blockers in heart failure due to systolic dysfunction
3. セクレチン secretin
4. 血管作動性腸管ポリペプチド vasoactive intestinal polypeptide
5. 喘息におけるβ刺激剤：長期使用に関する議論 beta agonists in asthma controversy regarding chronic use

English Journal

Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.

Glück L1, Loktev A1, Moulédous L2, Mollereau C2, Law PY3, Schulz S4.
Biological psychiatry.Biol Psychiatry.2014 Nov 15;76(10):767-74. doi: 10.1016/j.biopsych.2014.01.021. Epub 2014 Feb 3.
BACKGROUND: The clinical benefits of opioid drugs are counteracted by the development of tolerance and addiction. We provide in vivo evidence for the involvement of G protein-coupled receptor kinases (GRKs) in opioid dependence in addition to their roles in agonist-selective mu-opioid receptor (MOR)
PMID 24629717

Evaluation of the role of g protein-coupled receptor kinase 3 in desensitization of mouse odorant receptors in a Mammalian cell line and in olfactory sensory neurons.

Kato A1, Reisert J2, Ihara S3, Yoshikawa K1, Touhara K4.
Chemical senses.Chem Senses.2014 Nov;39(9):771-80. doi: 10.1093/chemse/bju050. Epub 2014 Oct 13.
Thousands of odors are sensed and discriminated by G protein-coupled odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs). G protein-coupled receptor kinases (GRKs) may have a role in desensitization of ORs. However, whether ORs are susceptible to agonist-dependent desensitization a
PMID 25313015

Multiple functions of G protein-coupled receptor kinases.

Watari K, Nakaya M, Kurose H1.
Journal of molecular signaling.J Mol Signal.2014 Mar 6;9(1):1. doi: 10.1186/1750-2187-9-1.
Desensitization is a physiological feedback mechanism that blocks detrimental effects of persistent stimulation. G protein-coupled receptor kinase 2 (GRK2) was originally identified as the kinase that mediates G protein-coupled receptor (GPCR) desensitization. Subsequent studies revealed that GRK is
PMID 24597858

Japanese Journal

ヒト過活動膀胱におけるムスカリンレセプター(M1,M2,M3)およびG蛋白質共役型受容体リン酸化酵素(GRK2,GRK3,GRK4)の発現量の変化

古谷泰久,神家満学,座光寺秀典,滝花義男,荒木勇雄,田邉信明,武田正之
日本泌尿器科學會雜誌 94(2), 396, 2003-02-15
NAID 110003072605

Myocardial overexpression of GRK3 in transgenic mice : evidence for in vivo selectivity of GRKs

IACCARINO G.
Am J Physiol 275, H1298-H1306, 1998
NAID 10010930413

G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization

PEPPEL K.
J. Biol. Chem. 272, 25425-25428, 1997
NAID 30016308089

Related Pictures

At our headquarters in Berg, we have an gartenarbeit schaedlingsbekaempfung grk3 Arrestin-Independent Internalization of G PVC-Teichfolie-1-mm-schwarz-Teichvlies-300 GRK3 /Immunofluorescence: GRK3

★リンクテーブル★

リンク元	「G-protein-coupled receptor kinase 3」「Gタンパク質共役受容体キナーゼ3」
関連記事	「GRK」「GR」

「G-protein-coupled receptor kinase 3」

GRK3
Identifiers
Aliases	GRK3, BARK2, ADRBK2, Beta adrenergic receptor kinase-2, G protein-coupled receptor kinase 3
External IDs	MGI: 87941 HomoloGene: 21072 GeneCards: GRK3
Targeted by Drug
	balanol
Gene ontology
Molecular function	• G-protein coupled receptor kinase activity; • ATP binding; • transferase activity; • protein kinase activity; • nucleotide binding; • protein serine/threonine kinase activity; • kinase activity; • beta-adrenergic receptor kinase activity;
Cellular component	• plasma membrane;
Biological process	• protein phosphorylation; • receptor internalization; • phosphorylation; • signal transduction;
	Sources:Amigo / QuickGO
RNA expression pattern
	; ;
	More reference expression data
Orthologs
	157
	320129
	ENSG00000100077
	ENSMUSG00000042249
	P35626
	Q3UYH7
	NM_005160
	NM_001035531; NM_001285806; NM_177078
	NP_005151.2
	NP_001272735.1; NP_796052.2
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

Gタンパク質共役受容体キナーゼ3

関: GRK3

「Gタンパク質共役受容体キナーゼ3」

　　[★]

英: G-protein-coupled receptor kinase 3、GRK3

「GRK」

　　[★]

Gタンパク質共役受容体キナーゼ

関: G-protein-coupled receptor kinase

関: G protein receptor kinase

「GR」

　　[★]

グルココルチコイド受容体

関: glucocorticoid receptor

[1] "Drugs that physically interact with Beta-adrenergic receptor kinase 2 view/edit references on wikidata".

[2] "Human PubMed Reference:".

[3] "Mouse PubMed Reference:".

[pmid7695743-4] Calabrese G, Sallese M, Stornaiuolo A, Stuppia L, Palka G, De Blasi A (Feb 1995). "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286–8. doi:10.1006/geno.1994.1497. PMID 7695743.

[entrez-5] "Entrez Gene: ADRBK2 adrenergic, beta, receptor kinase 2".

[pmid1869533-6] Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA, Gilbert DJ, Copeland NG, Caron MG, Lefkowitz RJ (August 1991). "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family". J. Biol. Chem. 266 (23): 14939–46. PMID 1869533.

[pmid8427589-7] Parruti G, Ambrosini G, Sallese M, De Blasi A (January 1993). "Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2". Biochem. Biophys. Res. Commun. 190 (2): 475–81. doi:10.1006/bbrc.1993.1072. PMID 8427589.

[pmid12808434-8] Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR (May 2003). "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder". Mol. Psychiatry. 8 (5): 546–57. doi:10.1038/sj.mp.4001268. PMID 12808434.

[pmid15006433-9] Yu SY, Takahashi S, Arinami T, Ohkubo T, Nemoto Y, Tanabe E, Fukura Y, Matsuura M, Han YH, Zhou RL, Shen YC, Matsushima E, Kojima T (February 2004). "Mutation screening and association study of the beta-adrenergic receptor kinase 2 gene in schizophrenia families". Psychiatry Res. 125 (2): 95–104. doi:10.1016/j.psychres.2003.12.003. PMID 15006433.

[pmid18274673-10] Balabanian K, Levoye A, Klemm L, et al. (March 2008). "Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling". J. Clin. Invest. 118 (3): 1074–84. doi:10.1172/JCI33187. PMC 2242619. PMID 18274673.

v t e Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

匿名

検索

案内

案内

GRK3