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English Journal

Tuning Cysteine Reactivity and Sulfenic Acid Stability by Protein Microenvironment in Glyceraldehyde-3-Phosphate Dehydrogenases of Arabidopsis Thaliana.

Zaffagnini M1, Fermani S2, Calvaresi M2, Orrù R1, Iommarini L1, Sparla F1, Falini G2, Bottoni A2, Trost P1.
Antioxidants & redox signaling.Antioxid Redox Signal.2016 Feb 1. [Epub ahead of print]
AIMS: Cysteines and H2O2 are fundamental players in redox signaling. Cysteine thiol deprotonation favors the reaction with H2O2 that generates sulfenic acids with dual electrophilic/nucleophilic nature. The protein microenvironment surrounding the target cysteine is believed to control whether sulfe
PMID 26650776

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

Yun J1, Mullarky E2, Lu C3, Bosch KN1, Kavalier A3, Rivera K4, Roper J5, Chio II4, Giannopoulou EG6, Rago C7, Muley A1, Asara JM8, Paik J9, Elemento O6, Chen Z10, Pappin DJ4, Dow LE1, Papadopoulos N7, Gross SS3, Cantley LC11.
Science (New York, N.Y.).Science.2015 Dec 11;350(6266):1391-6. doi: 10.1126/science.aaa5004. Epub 2015 Nov 5.
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations and are often refractory to approved targeted therapies. We found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C. This effect is due t
PMID 26541605

Deciphering the signaling mechanisms of the plant cell wall degradation machinery in Aspergillus oryzae.

Udatha DB1,2, Topakas E3, Salazar M4,5, Olsson L6,7, Andersen MR8, Panagiotou G9.
BMC systems biology.BMC Syst Biol.2015 Nov 14;9(1):77. doi: 10.1186/s12918-015-0224-5.
BACKGROUND: The gene expression and secretion of fungal lignocellulolytic enzymes are tightly controlled at the transcription level using independent mechanisms to respond to distinct inducers from plant biomass. An advanced systems-level understanding of transcriptional regulatory networks is requi
PMID 26573537