日
関

WordNet

a family of arboviruses carried by arthropods
animal viruses belonging to the family Flaviviridae

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/01 20:48:22」(JST)

wiki en

Flaviviridae

Virus classification
Virus group:	Group IV ((+)ssRNA)
Family:	Flaviviridae
Genera
Flavivirus Hepacivirus Pegivirus Pestivirus

The Flaviviridae are a family of viruses that are primarily spread through arthropod vectors (mainly ticks and mosquitoes). The family gets its name from Yellow Fever virus, a type virus of Flaviviridae; flavus means yellow in Latin. (Yellow fever in turn was named because of its propensity to cause jaundice in victims.).^[1]

Flaviviridae have monopartite, linear, single-stranded RNA genomes of positive polarity, 9.6 to 12.3 kilobase in length. The 5'-termini of flaviviruses carry a methylated nucleotide cap, while other members of this family are uncapped and encode an internal ribosome entry site. Virus particles are enveloped and spherical, about 40-60 nm in diameter.

Taxonomy

This family includes the following genera:

Genus Flavivirus (type species Yellow fever virus, others include West Nile virus and Dengue Fever)—contains 67 identified human and animal viruses
Genus Hepacivirus (type species Hepatitis C virus,^[2] the single member)
Genus Hepatitis G Virus (The GB agent and the hepatitis G virus (HGV))
Genus Pestivirus (type species bovine viral diarrhea virus, others include classical swine fever or hog cholera)—contains viruses infecting non-human mammals

Clinical importance

Major diseases caused by the Flaviviridae family include:

Dengue fever
Japanese encephalitis
Kyasanur Forest disease
Murray Valley encephalitis
St. Louis encephalitis
Tick-borne encephalitis
West Nile encephalitis
Yellow fever
Hepatitis C Virus Infection

References

^ http://microbewiki.kenyon.edu/index.php/Flaviviridae Accessed July 22, 2008
^ Paula T, Pablo R, Eugenia V, Pablo B, Sabino P, José M et al. (2009). "New drug targets for hepatitis C and other Flaviviridae viruses". Infect Disord Drug Targets 9 (2): 133–47. doi:10.2174/187152609787847749. PMID 19275702.

External links

Flaviviridae Genomes database search results from the Viral Bioinformatics Resource Center
Viralzone: Flaviviridae
Virus Pathogen Database and Analysis Resource (ViPR): Flaviviridae

This virus-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. C型肝炎ウイルスの特性 characteristics of the hepatitis c virus
2. 節足動物媒介性脳炎 arthropod borne encephalitides
3. デング熱ウイルス感染症の疫学 epidemiology of dengue virus infections
4. デング熱ウイルス感染症の病因 pathogenesis of dengue virus infection
5. セントルイス脳炎 st louis encephalitis

English Journal

Preliminary evaluation of DNA vaccine candidates encoding dengue-2 prM/E and NS1: their immunity and protective efficacy in mice.

Lu H, Xu XF, Gao N, Fan DY, Wang J, An J.SourceDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, PR China.
Molecular immunology.Mol Immunol.2013 Jun;54(2):109-14. doi: 10.1016/j.molimm.2012.11.007. Epub 2012 Dec 25.
Public health is still seriously threatened by dengue virus (DENV) and no vaccine against DENV is yet available for clinical use till now. In this study, DNA vaccine candidates encoding DENV serotype 2 (DENV-2) prM/E (premembrane and envelope proteins) and NS1 (non-structural 1 protein) with or with
PMID 23270684

Identification and molecular characterization of a novel flavivirus isolated from geese in China.

Huang X, Han K, Zhao D, Liu Y, Zhang J, Niu H, Zhang K, Zhu J, Wu D, Gao L, Li Y.SourceInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu Province, PR China.
Research in veterinary science.Res Vet Sci.2013 Jun;94(3):774-80. doi: 10.1016/j.rvsc.2012.11.014. Epub 2012 Dec 25.
Since April 2010, a novel contagious disease in ducks and geese, with egg drop, feed uptake decline and neurological signs, caused by a newly emerged virus has spread around Eastern China. Dissection conducted on the dead geese demonstrated hemorrhage in brain, lung, liver, heart, ovary, and enlarge
PMID 23270919

Potential anti-dengue medicinal plants: a review.

Abd Kadir SL, Yaakob H, Mohamed Zulkifli R.SourceDepartment of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia, slatifah2@live.utm.my.
Journal of natural medicines.J Nat Med.2013 Apr 17. [Epub ahead of print]
Dengue fever causes mortality and morbidity around the world, specifically in the Tropics and subtropic regions, which has been of major concern to governments and the World Health Organization (WHO). As a consequence, the search for new anti-dengue agents from medicinal plants has assumed more urge
PMID 23591999