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1. 日本脳炎：疫学、診断、治療、および予防 japanese encephalitis epidemiology diagnosis treatment and prevention

High-throughput virtual screening lead to discovery of non-peptidic inhibitors of west nile virus NS3 protease.

Huang D.SourceDepartment of Biochemistry, University of Zurich, Zurich, Switzerland, dhuang@bioc.uzh.ch.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2012;819:615-23.
The non-structural 3 protease is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus infections. In this chapter, we discuss in detail the computational methods used in the previous two docking campaigns which lead to the discov
PMID 22183561

Mastrangelo E, Bolognesi M, Milani M.SourceCNR-Istituto di Biofisica, Università degli Studi di Milano, via Celoria 26, 20133 Milano, Italy; Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, via Celoria 26, 20133 Milano, Italy.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2011 Nov 19. [Epub ahead of print]
Motor proteins are involved in crucial cell activities, such as cargo transport or nucleic acid remodeling, by converting the free energy of ATP hydrolysis into motion or mechanical work. Flavivirus helicase is a motor protein involved in dsRNA separation during viral replication, thus essential for
PMID 22138238