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1. ハーブ剤および栄養補助食品による肝毒性 hepatotoxicity due to herbal medications and dietary supplements
2. アスリートにおける高血圧 hypertension in athletes
3. 漢方薬および栄養補助食品の概要 overview of herbal medicine and dietary supplements
4. 心不全患者において使用をさけるべき、または慎重に使用するべき薬 drugs that should be avoided or used with caution in patients with heart failure
5. アレルギー疾患の治療のための漢方薬 chinese herbal medicine for the treatment of allergic diseases

English Journal

Pharmacokinetic Effects of Cinnamic Acid, Amygdalin, Glycyrrhizic Acid and Liquiritin on Ephedra Alkaloids in Rats.

Tang Y1, Zheng M1, Chen YL1, Chen J1, He Y2.
European journal of drug metabolism and pharmacokinetics.Eur J Drug Metab Pharmacokinet.2016 Aug 11. [Epub ahead of print]
BACKGROUND AND OBJECTIVES: Ephedra alkaloids, including ephedrine (EP), pseudoephedrine (PEP) and methylephedrine (MEP), are sympathomimetic compounds with known toxicities but many Ephedra (Ephedrae herba) preparations, such as Ephedra decoction, have been clinically applied for centuries. In order
PMID 27514823

Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells.

Nishimura Y1, Hyuga S2, Takiguchi S3, Hyuga M4, Itoh K5, Hanawa T2.
International journal of oncology.Int J Oncol.2016 May;48(5):1895-906. doi: 10.3892/ijo.2016.3426. Epub 2016 Mar 7.
The MET tyrosine kinase receptor and its ligand, hepatocyte growth factor (HGF), are known to be overexpressed in a variety of malignant tumor cells, and are implicated in the development of gefitinib-resistance in human non-small cell lung cancer (NSCLC) cells. Ephedrae herba was previously reporte
PMID 26983447

Stereoselective metabolism of amygdalin-based study of detoxification of Semen Armeniacae Amarum in the Herba Ephedrae-Semen Armeniacae Amarum herb pair.

Song S1, Ma Q1, Tang Q1, Chen F1, Xing X1, Guo Y2, Guo S1, Tan X1, Luo J3.
Journal of ethnopharmacology.J Ethnopharmacol.2016 Feb 17;179:356-66. doi: 10.1016/j.jep.2015.12.019. Epub 2015 Dec 21.
ETHNOPHARMACOLOGICAL RELEVANCE: The Mahuang-Xingren (MX) herb pair, the combination of Herba Ephedrae (Mahuang in Chinese) and Semen Armeniacae Amarum (Xingren in Chinese), is a core component of traditional Chinese medicine formulations used to treat asthma and bronchitis. Although Xingren is consi
PMID 26719286

笛木司,松岡尚則,別府正志,山口秀敏,中田英之,頼建守,坂井由美,長坂和彦,牧野利明,並木隆雄,岡田研吉,岩井泉,牧角和宏
Kampo Medicine 63(5), 313-321, 2012
北京市昌平区で採水した上水道水を用いてマオウを煎じ，これを新潟市の上水道水，及び数種の市販ミネラルウォーターによる煎液と比較し，水の性質が生薬からの成分の煎出に与える影響を検討した。日中の上水道水によるマオウ煎液には，種々の相違点が認められ，北京市の上水道水に対するマオウアルカロイドの移行率は，新潟市の上水道水における移行率に比べ，約80％であった。これらの現象には，水の一時硬度成分であるカルシウ …
NAID 130003369894