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1. 全身性硬化症（強皮症）の病因pathogenesis of systemic sclerosis scleroderma [show details]
…Nitric oxide (NO, or endothelium-derived relaxing factor) Endothelium-derived constricting factors (EDCF) Neural, humoral, and inflammatory mediators; Hypoxia; Physical stress; Derangements of endothelins…

English Journal

Nava E1, Llorens S2.
Pharmacological research.Pharmacol Res.2016 Aug 12;113(Pt A):125-145. doi: 10.1016/j.phrs.2016.08.003. [Epub ahead of print]
During the last quarter of the past century, the leading role the endocrine and nervous systems had on the regulation of vasomotion, shifted towards a more paracrine-based regulation. This begun with the recognition of endothelial cells as active players of vascular control, when the vessel's intima
PMID 27530204

Diffusional and transcriptional mechanisms involved in laccases production by Pleurotus ostreatus CP50.

Fernández-Alejandre KI1, Flores N1, Tinoco-Valencia R1, Caro M1, Flores C1, Galindo E1, Serrano-Carreón L2.
Journal of biotechnology.J Biotechnol.2016 Apr 10;223:42-9. doi: 10.1016/j.jbiotec.2016.02.029. Epub 2016 Feb 26.
The independent effects of hydrodynamic stress (assessed as the Energy Dissipation/Circulation Function, EDCF) and dissolved oxygen tension (DOT) on the growth, morphology and laccase production by Pleurotus ostreatus CP50 were studied using a 3(2) factorial design in a 10L reactor. A bell-shape fun
PMID 26924241

Endothelium-Dependent Contractions: Prostacyclin and Endothelin-1, Partners in Crime?

Baretella O1, Vanhoutte PM2.
Advances in pharmacology (San Diego, Calif.).Adv Pharmacol.2016;77:177-208. doi: 10.1016/bs.apha.2016.04.006. Epub 2016 Jun 6.
Both the lipid prostacyclin and the peptide endothelin-1 are endothelium-derived substances. Endothelin-1 is one of the most powerful endogenous vasoconstrictors, while prostacyclin is a potent antiaggregatory and vasodilator mediator upon activation of prostaglandin I2 (IP) receptors. During endoth
PMID 27451098

松本貴之
YAKUGAKU ZASSHI 130(6), 777-784, 2010
… Moreover, it has been suggested that the imbalance between EDRFs and EDCFs is present in mesenteric arteries from type 2 diabetic rats and the EDHF relaxation can be partly reversed by suppression of EDCF signaling. … Indeed, chronic treatment with metformin, eicosapentaenoic acid, or thromboxane synthase inhibitor can reduce EDCF signaling and normalize EDHF signaling in mesenteric arteries from type 2 diabetic rats. …
NAID 130000259469

Pyrrolidine Dithiocarbamate Reduces Vascular Prostanoid-Induced Responses in Aged Type 2 Diabetic Rat Model

Matsumoto Takayuki,Ishida Keiko,Kobayashi Tsuneo [他],KAMATA Katsuo
Journal of pharmacological sciences 110(3), 326-333, 2009-07-20
… The arachidonic acid–induced contraction and the acetylcholine-induced endothelium-derived contracting factor (EDCF)-mediated contraction in mesenteric arteries were also compared among these groups. … OLETF rats exhibited (vs. age-matched LETO rats) the following: increased responses to both arachidonic acid and EDCF and greater productions of PGE2 and TXA2. …
NAID 10025737700

VANHOUTTE Paul M.
Circulation journal : official journal of the Japanese Circulation Society 73(4), 595-601, 2009-03-20
… Endothelial cells also release endothelium-derived contracting factors (EDCF). … EDCF-mediated responses are augmented by aging, hypertension and diabetes. …
NAID 10025928764