同: Dohle小体

WordNet

invest with or as with a body; give body to (同)personify
the external structure of a vehicle; "the body of the car was badly rusted"
the main mass of a thing
a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
the central message of a communication; "the body of the message was short"

PrepTutorEJDIC

〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
《英話》人;(特に)男

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/28 14:18:31」(JST)

wiki en

Döhle bodies are light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1-3 µm in diameter. Not much is known about their formation, but are thought to be remnants of the rough endoplasmic reticulum.

They are named after German pathologist, Karl Gottfried Paul Döhle (1855-1928).^[1]^[2]

They often present in conjunction with toxic granulation.^[3]

Associated conditions

They are seen in:

Burns
Infections
Physical trauma
Neoplastic diseases
Wissler’s disease
May-Hegglin anomaly
Chédiak-Steinbrinck-Higashi’s syndrome

Pathophysiology

The presence of Döhle bodies in mature and immature neutrophils on a blood smear can be normal if they are present only in small numbers. They are also normally more abundant in cats and horses. Döhle bodies are intra-cytoplasmic structures composed of agglutinated ribosomes; they will increase in number with inflammation and increased granulocytopoiesis. If there are many neutrophils in the bloodstream containing Döhle bodies, these can be referred to as toxic neutrophils. Toxic neutrophils can also correspond to neutrophils that possess a more basophilic cytoplasm, basophilic granulation (infrequently observed), or cytoplasmic vacuoles in addition to one of the preceding cytoplasmic changes. Döhle bodies, cytoplasmic basophilia and cytoplasmic granulation all reflect "defects" in cell production and maturation during active granulocytopoiesis. Just like a left shift, the presence of toxic neutrophils suggests increased granulocytopoiesis. However, in a freshly prepared blood smear, the presence of vacuolation in addition to toxic neutrophils, reflects endotoxemia resulting in autolysis of neutrophils. This autodigestion is responsible for the cytoplasmic vacuolation. It is the single toxic change that does not result from the "manufacturing" process.

References

^ synd/114 at Who Named It?
^ K. G. P. Döhle. Vorläufige Mittheilung über Blutbefunde bei Masern. Zentralblatt für allgemeine Pathologie und pathologische Anatomie, Jena, 1892, 3: 150-152.
^ "Döhle body". http://www.academic.marist.edu/~jzmz/topics/bloodsmears/bloodsmears24.html. Retrieved 2009-02-10.

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English Journal

Representation of virtual arm movements in precuneus.

Dohle C, Stephan KM, Valvoda JT, Hosseiny O, Tellmann L, Kuhlen T, Seitz RJ, Freund HJ.SourceMedian Klinik Berlin-Kladow, Kladower Damm 223, 14089 Berlin, Germany. christian.dohle@median-kliniken.de
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale.Exp Brain Res.2011 Feb;208(4):543-55. Epub 2010 Dec 25.
Arm movements can easily be adapted to different biomechanical constraints. However, the cortical representation of the processing of visual input and its transformation into motor commands remains poorly understood. In a visuo-motor dissociation paradigm, subjects were presented with a 3-D computer
PMID 21188363

Sperm quality decline among men below 60 years of age undergoing IVF or ICSI treatment.

Hammiche F, Laven JS, Boxmeer JC, Dohle GR, Steegers EA, Steegers-Theunissen RP.SourceDepartment of Obstetrics and Gynecology, Erasmus MC, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
Journal of andrology.J Androl.2011 Jan-Feb;32(1):70-6. Epub 2010 May 13.
Because of changes in the society, couples in Western countries are increasingly delaying reproduction. This is accompanied by unhealthy lifestyles that may be detrimental not only to general health but also to reproductive capacity. It is well known that maternal age has detrimental effects on fert
PMID 20467050