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- fine meal made from cereal grain especially wheat; often used as a cooked cereal or in puddings
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- 穀粉(スープ・プディングなどに用いる)
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/07 16:24:45」(JST)
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- 1. アレルギー性鼻炎および喘息に対する舌下免疫療法 sublingual immunotherapy for allergic rhinoconjunctivitis and asthma
- 2. アレルギーおよび免疫学の最新情報 whats new in allergy and immunology
- 3. アレルゲン抽出液：組成、製造および表示 allergen extracts composition manufacture and labeling
- 4. 薬物療法の最新情報 whats new in drug therapy
- 5. 皮下免疫療法によって引き起こされるアナフィラキシー anaphylaxis induced by subcutaneous allergen immunotherapy
English Journal
- Acaricidal activities of bicyclic monoterpene ketones from Artemisia iwayomogi against Dermatophagoides spp.
- Jeon JH1, Kim MG, Lee HS.Author information 1Department of Bioenvironmental Chemistry, College of Agriculture and Life Science, Institute of Agricultural Science and Technology, Chonbuk National University, Jeonju, 561-756, Republic of Korea.AbstractThe acaricidal properties of 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one isolated from Artemisia iwayomogi and its structural analogues were evaluated against Dermatophagoides farinae and D. pteronyssinus, and their effects were compared with that of the commercial acaricide benzyl benzoate. Based on the 50 % lethal dose (LD50) values against D. farinae, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (0.82 μg/cm(2)) was 9.71 times more effective than benzyl benzoate (7.96 μg/cm(2)), followed by (1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (1.03 μg/cm(2)), (1S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (1.58 μg/cm(2)), and (1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one oxime (3.05 μg/cm(2)) in a filter paper bioassay. The acaricidal activities of 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one and its structural analogues against D. pteronyssinus were similar to those against D. farinae. These results demonstrate that naturally occurring A. iwayomogi-isolated 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one and its structural analogues are suitable for the production of natural acaricides against house dust mites.
- Experimental & applied acarology.Exp Appl Acarol.2014 Mar;62(3):415-22. doi: 10.1007/s10493-013-9739-x. Epub 2013 Oct 10.
- The acaricidal properties of 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one isolated from Artemisia iwayomogi and its structural analogues were evaluated against Dermatophagoides farinae and D. pteronyssinus, and their effects were compared with that of the commercial acaricide benzyl benzoate. Based on
- PMID 24114336
- Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner.
- Kawano T1, Matsuse H1, Tsuchida T1, Fukahori S2, Fukushima C1, Nishino T1, Kohno S1.Author information 1Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.2Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.AbstractBackground Cysteinyl leukotrienes (cys-LTs) are very important factors in the pathophysiology of bronchial asthma. Cys-LT receptor antagonists (LTRAs) decrease allergic airway inflammation. The aim of the present study was to determine the differential effects of LTRAs and corticosteroids on allergic airway inflammation and allergen-specific cytokine production from lymphoid tissues using a murine model of asthma. Material and Methods Four groups of female BALB/c mice [control (Cont); Dermatophagoides farinae allergen-sensitized (AS); pranlukast (Prl), an LTRA-treated AS; and dexamethasone (Dex)-treated AS] were examined. Lung pathology and cytokine production by prepared mononuclear cells isolated from mediastinal lymph nodes (MLNs) and spleen were compared among these groups. Results AS mice exhibited allergic airway inflammation and significant increases in allergen-specific Th1 and Th2 cytokines in MLNs and spleen. Prl-treated mice showed significant attenuation of allergic airway inflammation concomitant with reduction of Th2 cytokines and IFN-g in MLNs but not in spleen. In contrast, Dex significantly decreased Th1 and Th2 cytokines in MLNs and also decreased them (except IL-13 and IL-2) in spleen. Conclusions The inflammatory effects of cys-LTs could differ in lymphoid organs. LTRAs potentially regulate allergic airway inflammation in an organ- and cytokine-specific manner, while systemic corticosteroid shows nonspecific effects.
- Medical science monitor : international medical journal of experimental and clinical research.Med Sci Monit.2014 Feb 22;20:297-302. doi: 10.12659/MSM.889865.
- Background Cysteinyl leukotrienes (cys-LTs) are very important factors in the pathophysiology of bronchial asthma. Cys-LT receptor antagonists (LTRAs) decrease allergic airway inflammation. The aim of the present study was to determine the differential effects of LTRAs and corticosteroids on allergi
- PMID 24561545
- Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization.
- Parsons MW1, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA.Author information 1Department of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115;AbstractThe myeloid C-type lectin receptor Dectin-2 directs the generation of Th2 and Th17 immune responses to the house dust mite Dermatophagoides farinae through the generation of cysteinyl leukotrienes and proinflammatory cytokines, respectively, but a role for Dectin-2 in effector phase responses has not been described. In this study, we demonstrate that administration of the Dectin-2 mAb solely at the time of D. farinae challenge abrogated eosinophilic and neutrophilic inflammation in the bronchoalveolar lavage fluid and Th1, Th2, and Th17 inflammation in the lung of previously sensitized mice. Furthermore, Dectin-2 null mice (Clec4n(-/-)) sensitized with the adoptive transfer of D. farinae-pulsed wild-type (WT) bone marrow-derived dendritic cells (DCs) also had less D. farinae-elicited pulmonary inflammation, supporting an effector function for Dectin-2. The protection from pulmonary inflammation seen with the Dectin-2 mAb or in Clec4n(-/-) mice was associated with little or no reduction in lung-draining lymph node cells or their cytokine production and with no reduction in serum IgE. WT and Clec4n(-/-) mice recipients, sensitized with D. farinae-pulsed WT bone marrow-derived DCs, had comparable levels of D. farinae-elicited IL-6, IL-23, TNF-α, and cysteinyl leukotrienes in the lung. By contrast, D. farinae-elicited CCL4 and CCL8 production from pulmonary CD11c(+)CD11b(+)Ly6C(+) and CD11c(+)CD11b(+)Ly6C(-)CD64(+) monocyte-derived DCs was reduced in Clec4n(-/-) recipients. Addition of CCL8 at the time of D. farinae challenge abrogated the protection from eosinophilic, neutrophilic, and Th2 pulmonary inflammation seen in Clec4n(-/-) recipients. Taken together, these results reveal that Dectin-2 regulates monocyte-derived DC function in the pulmonary microenvironment at D. farinae challenge to promote the local inflammatory response.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Feb 15;192(4):1361-71. doi: 10.4049/jimmunol.1301809. Epub 2014 Jan 22.
- The myeloid C-type lectin receptor Dectin-2 directs the generation of Th2 and Th17 immune responses to the house dust mite Dermatophagoides farinae through the generation of cysteinyl leukotrienes and proinflammatory cytokines, respectively, but a role for Dectin-2 in effector phase responses has no
- PMID 24453247
Japanese Journal
- Immunization of Rabbits with Nematode Ascaris lumbricoides Antigens Induces Antibodies Cross-Reactive to House Dust Mite Dermatophagoides farinae Antigens
- NAKAZAWA Takuya,KHAN Al Fazal,YASUEDA Hiroshi [他]
- Bioscience, Biotechnology, and Biochemistry 77(1), 145-150, 2013-01
- NAID 40019561928
- Propolis Inhalation Reduces Allergic Airway Inflammation in Dermatophagoides farinae -treated Mice
- Hirota Ryoji,Ngatu Nlandu Roger,Nakamura Hiroyuki [他]
- 日本予防医学会雑誌 7(3), 103-110, 2012-12
- NAID 40019551917
- ダニ抗原誘発性難治性皮膚炎に対する新規免疫調節薬FTY720とベタメタゾン軟膏併用療法の有用性 : NC/Ngaマウスを用いた検討
- 辻 琢己,吉田 侑矢,藤多 哲朗,河野 武幸
- アレルギー 61(7), 948-958, 2012-07-30
- … 【背景と目的】難治性皮膚炎に対するFTY720とベタメタゾン軟膏併用療法の有用性をNC/Ngaマウスを用いて検討した.【方法】ダニ(Dermatophagoides farinae)抗原で難治性皮膚炎を発症させたNC/Ngaマウスをベタメタゾン吉草酸エステル軟膏(1日1回,週6回塗布), FTY720 (3mg/kg, 2日または3日に1回,週3回経口投与), FTY720+ベタメタゾン併用,軟膏基剤(1日1回,週6回塗布), FTY720+基剤併用およびプラセボで2週間治療し,治療効果を …
- NAID 110009489268
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