For other uses, see Datura (disambiguation).
For other plants with the name "Angel's trumpet", see Angel's trumpet.
Datura |
|
Datura metel |
Scientific classification |
Kingdom: |
Plantae |
(unranked): |
Angiosperms |
(unranked): |
Eudicots |
(unranked): |
Asterids |
Order: |
Solanales |
Family: |
Solanaceae |
Subfamily: |
Solanoideae |
Tribe: |
Datureae |
Genus: |
Datura
L. |
Type species |
Datura stramonium
L. |
Species |
See text below
|
Datura is a genus of nine species of poisonous vespertine flowering plants belonging to the family Solanaceae. They are known as angel's trumpets, sometimes sharing that name with the closely related genus Brugmansia, and commonly as daturas. They are also sometimes called moonflowers, one of several plant species to be so. Its precise and natural distribution is uncertain, owing to its extensive cultivation and naturalization throughout the temperate and tropical regions of the globe. Its distribution within the Americas and North Africa, however, is most likely restricted to the United States and Mexico in North America, and Tunisia in Africa, where the highest species diversity occurs.
All species of Datura are poisonous, especially their seeds and flowers.
Some South American plants formerly thought of as Datura are now treated as belonging to the distinct genus Brugmansia[1] (Brugmansia differs from Datura in that it is woody, making shrubs or small trees, and it has pendulous flowers, rather than erect ones). Other related genera include Hyoscyamus and Atropa.
Contents
- 1 Etymology
- 2 Description
- 3 Species and cultivars
- 3.1 Past classified species
- 4 Cultivation
- 5 Toxicity
- 5.1 Effects of ingestion
- 5.2 Treatment
- 6 Gallery
- 7 See also
- 8 References
- 9 Further reading
- 10 External links
Etymology
The Neo-Latin name Datura is taken from Hindi धतूरा dhatūra 'jimson weed',[2] ultimately from Sanskrit धत्तूर dhattūra 'white thorn-apple'.[3]
Description
Datura species are herbaceous, leafy annuals and short-lived perennials which can reach up to 2 m in height. The leaves are alternate, 10–20 cm long and 5–18 cm broad, with a lobed or toothed margin. The flowers are erect or spreading (not pendulous like those of Brugmansia), trumpet-shaped, 5–20 cm long and 4–12 cm broad at the mouth; colors vary from white to yellow, pink, and pale purple. The fruit is a spiny capsule 4–10 cm long and 2–6 cm broad, splitting open when ripe to release the numerous seeds. The seeds disperse freely over pastures, fields and even wasteland locations.
Datura belongs to the classic "witches' weeds", along with deadly nightshade, henbane, and mandrake. Most parts of the plants are toxic, and datura has a long history of use for causing delirious states and death. It was well known as an essential ingredient of potions and witches' brews.[4]
The word datura comes from the sanskrit dhatūr ("thorn apple"); In Sanskrit it is referred as "Kanak" and "Unmatt" in the ancient scriptures of Indian Ayurveda by sage Sushrut and Charaka. Record of this name in English dates back to 1662.[5] Nathaniel Hawthorne refers to one type in The Scarlet Letter as apple-Peru. In Mexico, its common name is toloache.
In India it has been referred and attributed to as "Poisonous" and aphrodisiac. In little measures it was used in Ayurveda as a medicine from the ancient times. It is used in rituals and prayers to Shiva.
The larvae of some Lepidoptera (butterfly and moth) species, including Hypercompe indecisa, eat some Datura species.
Species and cultivars
It is difficult to classify Datura as to its species, and it often happens that the descriptions of new species are accepted prematurely. Later, these "new species" are found to be simply varieties that have evolved due to conditions at a specific location. They usually disappear in a few years. Contributing to the confusion is the fact that various species, such as D. wrightii and D. inoxia, are very similar in appearance, and the variation within a species can be extreme. For example, Datura species can change size of plant, leaf, and flowers, all depending on location. The same species, when growing in a half-shady, damp location can develop into a flowering bush half as tall as a person, but when growing in a very dry location, will only grow into a thin plant not much more than ankle-high, with tiny flowers and a few miniature leaves.[4]
Today, experts classify only nine species of Datura:[4]
- D. ceratocaula Jacq. – torna loco
- D. discolor Bernh. – desert thorn-apple
- D. ferox L. – long-spined thorn-apple
- D. inoxia Mill. – thorn-apple, downy thorn-apple, Indian-apple, moonflower, sacred datura, toloatzin, toloache
- D. leichhardtii F.Muell. ex Benth. (syn. D. pruinosa) – Leichhardt's datura
- D. metel L. – devil's trumpet[4]
- D. quercifolia Kunth – oak-leaf thorn-apple
- D. stramonium L. (syn. D. inermis) – jimsonweed, thorn-apple
- D. wrightii Regel – sacred datura, sacred thorn-apple
American Brugmansia and Datura Society, Inc. (ABADS) is designated in the 2004 edition of the International Code of Nomenclature for Cultivated Plants as the official International Cultivar Registration Authority for Datura. This role was delegated to ABADS by the International Society for Horticultural Science in 2002.
Past classified species
- D. bernhardii
- D. kymatocarpa
- D. lanosa
- D. reburra
- D. suaveolens
Cultivation
D. inoxia with ripe, split-open fruit
Datura species are usually planted annually from the seed produced in the spiny pods, but with care, plants can be overwintered. Most species are suited to being planted outside or in containers. As a rule, they need warm, sunny places and soil that will keep their roots dry. When grown outdoors in good locations, the plants tend to reseed themselves and may become invasive. In containers, they should have porous, aerated potting soil with adequate drainage. The plants are susceptible to fungi in the root area, so organic enrichment such as compost and manure should be avoided.[4]
Toxicity
All Datura plants contain tropane alkaloids such as scopolamine, hyoscyamine, and atropine, primarily in their seeds and flowers. Because of the presence of these substances, Datura has been used for centuries in some cultures as a poison.[4][6] There can be a 5:1 toxin variation between plants, and a given plant's toxicity depends on its age, where it is growing, and the local weather conditions. This variation makes Datura exceptionally hazardous as a drug.
In traditional cultures, a great deal of experience with and detailed knowledge of Datura was critical to minimize harm.[4] Many tragic incidents result from modern users ingesting Datura. For example, in the 1990s and 2000s, the United States media contained stories of adolescents and young adults dying or becoming seriously ill from intentionally ingesting Datura.[7][8] There are also several reports in the medical literature of deaths from D. stramonium and D. ferox intoxication.[9][10][11] Children are especially vulnerable to atropine poisoning, and their prognosis is likely to be death.[12][13]
Datura toxins may be ingested accidentally by consumption of honey produced by several wasp species, including Brachygastra lecheguana, during the Datura blooming season. It appears that these semi-domesticated honey wasps collect Datura nectar for honey production which can lead to poisoning.[14]
In some parts of Europe and India, Datura has been a popular poison for suicide and murder. From 1950 to 1965, the State Chemical Laboratories in Agra, India, investigated 2,778 deaths caused by ingesting Datura.[4][15]
The US Centers for Disease Control and Prevention reported accidental poisoning resulting in hospitalization for a family of six who inadvertently ingested Datura used as an ingredient in stew.[16]
In some places, it is prohibited to buy, sell, or cultivate Datura plants.[4][15]
Effects of ingestion
Due to the potent combination of anticholinergic substances it contains, Datura intoxication typically produces effects similar to that of an anticholinergic delirium (usually involving a complete inability to differentiate reality from fantasy); hyperthermia; tachycardia; bizarre, and possibly violent behavior; and severe mydriasis (dilated pupils) with resultant painful photophobia that can last several days. Pronounced amnesia is another commonly reported effect.[17]
No other substance has received as many severely negative recreational experience reports as has Datura. The overwhelming majority of those who describe their use of Datura find their experiences extremely unpleasant both mentally and often physically dangerous.[17]
Treatment
Due to their agitated behavior and confused mental state, victims of Datura poisoning are typically hospitalized. Stomach pumping and the administration of activated charcoal can be used to reduce the stomach's absorption of the ingested material. The drug physostigmine is used to reverse the effect of the poisons. Benzodiazepines can be given to curb the patient's agitation, and supportive care with oxygen, hydration, and symptomatic treatment is often provided. Observation of the patient is indicated until the symptoms resolve, usually from 24–36 hours after ingestion of the Datura.[15][18]
Gallery
-
Datura flower on the plant (lateral view) near Hyderabad, Andhra Pradesh, India
-
Datura flower on the plant (top view) near Hyderabad, Andhra Pradesh, India
-
Datura in bloom. Taken on Sullivan Road, Twentynine Palms, CA 28July2014
See also
- Donnatal, a pharmaceutical containing the active alkaloids in Belladonna, a plant similar to Datura: scopolamine, hyoscyamine, and atropine, as a drug
References
- ^ Lester, R. N.; Nee, M.; Estrada, N. (1991). Hawkes, J. G., ed. Solanaceae III – Taxonomy, Chemistry, Evolution (Proceedings of Third International Conference on Solanaceae). Kew: Royal Botanic Gardens. pp. 197–210. ISBN 0-947643-31-1.
- ^ American Heritage Dictionary: datura
- ^ Monier Monier-Williams, A Sanskrit-English Dictionary.
- ^ a b c d e f g h i Preissel, U.; Preissel, H.-G. (2002). Brugmansia and Datura: Angel's Trumpets and Thorn Apples. Buffalo, NY: Firefly Books. pp. 106–129. ISBN 1-55209-598-3.
- ^ the Oxford English Dictionary or OED
- ^ Adams, J. D. Jr.; Garcia, C. (2005). "Spirit, Mind and Body in Chumash Healing". Evidence-based Complementary and Alternative Medicine 2 (4): 459–463. doi:10.1093/ecam/neh130. PMC 1297503. PMID 16322802.
- ^ Goetz, R.; Siegel, E.; Scaglione, J.; Belson, M.; Patel, M. (2003). "Suspected Moonflower Intoxication -- Ohio, 2002". MMWR Morbidity and Mortality Weekly Report (CDC) 52 (33): 788–791. PMID 12931077.
- ^ Leinwand, D. (2006-11-01). USA TODAY http://www.usatoday.com/news/nation/2006-11-01-jimson_x.htm. Retrieved 2009-02-15.
- ^ Michalodimitrakis, M.; Koutselinis, A. (1984). "Discussion of "Datura stramonium: A fatal poisoning"". Journal of Forensic Sciences 29 (4): 961–962. PMID 6502123.
- ^ Boumba, V. A.; Mitselou, A.; Vougiouklakis, T. (2004). "Fatal poisoning from ingestion of Datura stramonium seeds". Veterinary and Human Toxicology 46 (2): 81–82. PMID 15080209.
- ^ Steenkamp, P. A.; Harding, N. M.; Van Heerden, F. R.; Van Wyk, B.-E. (2004). "Fatal Datura poisoning: Identification of atropine and scopolamine by high performance liquid chromatography / photodiode array / mass spectrometry". Forensic Science International 145 (1): 31–39. doi:10.1016/j.forsciint.2004.03.011. PMID 15374592.
- ^ Taha, S. A.; Mahdi, A. H. (1984). "Datura intoxication in Riyadh". Transactions of the Royal Society of Tropical Medicine and Hygiene 78 (1): 134–135. doi:10.1016/0035-9203(84)90196-2. PMID 6710568.
- ^ Djibo, A.; Bouzou, S. B. (2000). "[Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]". Bulletin de la Société de Pathologie Exotique (in French) 93 (4): 294–297. PMID 11204734.
- ^ Bequaert, J.Q. (1932). “The Nearctic social wasps of the subfamily polybiinae (Hymenoptera; Vespidae)". Entomologica Americana. 13(3):87-150.
- ^ a b c Andrews, Dale (2013-02-28). "Daturas". Crime Poisons. Washington: SleuthSayers. Retrieved 4 March 2013.
- ^ Bontoyan, W.; et al. (2010-02-05). "Jimsonweed Poisoning Associated with a Homemade Stew – Maryland, 2008" (pdf). Centers for Disease Control and Prevention – Morbidity and Mortality Weekly Report 59 (4): 102–103. Retrieved 2010-02-11.
- ^ a b Freye, E. (2010). "Toxicity of Datura Stramonium". Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs. Netherlands: Springer. pp. 217–218. doi:10.1007/978-90-481-2448-0_34. ISBN 978-90-481-2447-3.
- ^ Bliss, M. (2001). "Datura Plant Poisoning" (pdf). Clinical Toxicology Review 23 (6).
Further reading
- Rätsch, C. (1998, 2005). The Encyclopedia of Psychoactive Plants. Rochester, VT: Park Street Press. ISBN 978-0-89281-978-2.
- Bliss, M. (2001). "Datura Plant Poisoning" (pdf). Clinical Toxicology Review 23 (6).
- Tropane Alkaloid Poisoning on eMedicine
- Roblot, F; Montaz, L; Delcoustal, M; Gaboriau, E; Chavagnat, JJ; Morichaud, G; Pourrat, O; Scepi, M; Patte, D (1995). "[Datura stramonium poisoning: the diagnosis is clinical, treatment is symptomatic].". La Revue de medecine interne / fondee ... par la Societe nationale francaise de medecine interne (in French) 16 (3): 187–90. doi:10.1016/0248-8663(96)80689-8. PMID 7740228.
- Krenzelok, Edward P. (February 2010). "Aspects of poisoning and treatment". Clinical Toxicology 48 (2): 104–110. doi:10.3109/15563651003630672. PMID 20229618.
External links
|
Wikimedia Commons has media related to Datura. |
|
Wikispecies has information related to: Datura |
- "PLANTS Profile: Datura L.". USDA Natural Resources Conservation Service.
- "GRIN Species Records of Datura". USDA Germplasm Resources Information Network (GRIN).
- "Datura Vault". Erowid.
Hallucinogens
|
|
Psychedelics
5-HT2AR agonists |
Lysergamides
|
- AL-LAD
- ALD-52
- BU-LAD
- IP-LAD
- Diallyllysergamide
- Dimethyllysergamide
- Ergometrine
- ETH-LAD
- LAE-32
- LPD-824
- LSA
- LSD
- LSD-Pip
- LSH
- LSM-775
- Lysergic acid 2-butyl amide
- LSZ
- Lysergic acid 3-pentyl amide
- Methylergometrine
- Methylisopropyllysergamide
- Methysergide
- N1-Methyl-lysergic acid diethylamide
- PARGY-LAD
- PRO-LAD
|
|
Phenethylamines
|
|
|
Piperazines
|
|
|
Tryptamines
|
- 1-Methyl-5-methoxy-diisopropyltryptamine
- 2,N,N-TMT
- 4,5-DHP-AMT
- 4,5-DHP-DMT
- 4-Acetoxy-DALT
- 4-Acetoxy-DET
- 4-Acetoxy-DiPT
- 4-Acetoxy-DMT
- 4-Acetoxy-DPT
- 4-Acetoxy-MiPT
- 4-HO-5-MeO-DMT
- 4-HO-DBT
- 4-HO-DPT
- 4-HO-MET
- 4-HO-MPMI
- 4-HO-MPT
- 4,N,N-TMT
- 4-Propionyloxy-DMT
- 5,6-diBr-DMT
- 5-AcO-DMT
- 5-Bromo-DMT
- 5-Me-MIPT
- 5-MeO-2,N,N-TMT
- 5-MeO-4,N,N-TMT
- 5-MeO-α,N,N-TMT
- 5-MeO-α-ET
- 5-MeO-α-MT
- 5-MeO-DALT
- 5-MeO-DET
- 5-MeO-DiPT
- 5-MeO-DMT
- 5-MeO-DPT
- 5-MeO-EiPT
- 5-MeO-MET
- 5-MeO-MiPT
- 5-MeO-MPMI
- 5-N,N-TMT
- 7,N,N-TMT
- α-ET
- α-MT
- α,N,N-TMT
- Aeruginascin
- Baeocystin
- Bufotenin
- DALT
- DBT
- DCPT
- DET
- DIPT
- DMT
- DPT
- EiPT
- Ethocin
- Ethocybin
- Ibogaine
- Iprocin
- MET
- Miprocin
- MiPT
- Norbaeocystin
- Noribogaine
- PiPT
- Psilocin
- Psilocybin
- Voacangine
|
|
Others
|
- AL-38022A
- ALPHA
- Dimemebfe
- Efavirenz
- Elemicin
- M-ALPHA
- Myristicin
- RH-34
|
|
|
Dissociatives
NMDAR antagonists |
Adamantanes
|
- Amantadine
- Memantine
- Rimantadine
|
|
Arylcyclohexylamines
|
- 3-MeO-PCP
- 4-MeO-PCP
- Dieticyclidine
- Diphenidine
- Esketamine
- Ethketamine
- Eticyclidine
- Gacyclidine
- Ketamine
- Methoxetamine
- Methoxyketamine
- Neramexane
- PCPr
- Phencyclidine
- Rolicyclidine
- Tenocyclidine
- Tiletamine
|
|
Morphinans
|
- Dextrallorphan
- Dextromethorphan
- Dextrorphan
- Racemethorphan
- Racemorphan
|
|
Others
|
- 2-MDP
- 8A-PDHQ
- Aptiganel
- Dexoxadrol
- Dizocilpine
- Etoxadrol
- Ibogaine
- Midafotel
- NEFA
- Nitrous oxide
- Noribogaine
- Perzinfotel
- Remacemide
- Selfotel
- Xenon
|
|
|
Deliriants
mAChR antagonists |
- 3-Quinuclidinyl benzilate
- Atropine
- Benactyzine
- Benzatropine
- Benzydamine
- Biperiden
- BRN-1484501
- Brompheniramine
- CAR-226,086
- CAR-301,060
- CAR-302,196
- CAR-302,282
- CAR-302,368
- CAR-302,537
- CAR-302,668
- Chloropyramine
- Chlorphenamine
- Clemastine
- CS-27349
- Cyclizine
- Cyproheptadine
- Dicycloverine
- Dimenhydrinate
- Diphenhydramine
- Ditran
- Doxylamine
- EA-3167
- EA-3443
- EA-3580
- EA-3834
- Flavoxate
- Hyoscyamine
- Meclozine
- Mepyramine
- N-Ethyl-3-piperidyl benzilate
- N-Methyl-3-piperidyl benzilate
- Orphenadrine
- Oxybutynin
- Pheniramine
- Phenyltoloxamine
- Procyclidine
- Promethazine
- Scopolamine
- Tolterodine
- Trihexyphenidyl
- Tripelennamine
- Triprolidine
- WIN-2299
|
|
Miscellaneous |
Cannabinoids
CB1R agonists
|
Phytocannabinoids
|
- Cannabinol
- THC (Dronabinol)
- THCV
- (Cannabidiol has different mechanism of action)
|
|
Synthetic
|
- 4-HTMPIPO
- 5F-PB-22
- AB-001
- AB-005
- A-836,339
- AB-CHMINACA
- AB-FUBINACA
- AB-PINACA
- ADB-FUBINACA
- ADB-PINACA
- ADBICA
- AM-630
- AM-679
- AM-694
- AM-1220
- AM-1221
- AM-1235
- AM-1241
- AM-1248
- AM-2201
- AM-2232
- AM-2233
- APICA
- APINACA
- CB-13
- CP 47,497
- CP 55,244
- CP 55,940
- DMHP
- HU-210
- HU-308
- JWH-007
- JWH-015
- JWH-018
- JWH-019
- JWH-030
- JWH-073
- JWH-081
- JWH-098
- JWH-116
- JWH-122
- JWH-149
- JWH-167
- JWH-182
- JWH-193
- JWH-198
- JWH-200
- JWH-203
- JWH-210
- JWH-250
- JWH-251
- JWH-398
- JWH-424
- JTE 7-31
- JTE-907
- Levonantradol
- MAM-2201
- MDA-19
- MN-25
- NESS-0327
- NESS-040C5
- Nabilone
- Nabitan
- Org 28611
- Parahexyl
- QUCHIC
- QUPIC
- RCS-4
- RCS-8
- SDB-006
- STS-135
- THC-O-acetate
- THC-O-phosphate
- UR-144
- WIN 55,212-2
- XLR-11
|
|
|
D2R agonists
|
- Apomorphine
- Aporphine
- Bromocriptine
- Cabergoline
- Lisuride
- Memantine
- Nuciferine
- Pergolide
- Piribedil
- Pramipexole
- Ropinirole
- Rotigotine
Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, methamphetamine), and precursors (levodopa).
|
|
GABAAR agonists
|
- Eszopiclone
- Gaboxadol
- Ibotenic acid
- Muscimol
- Zaleplon
- Zolpidem
- Zopiclone
|
|
Inhalants
Mixed MOA
|
- Aliphatic hydrocarbons
- Butane
- Gasoline
- Kerosene
- Propane
- Aromatic hydrocarbons
- Ethers
- Haloalkanes
- Chlorofluorocarbons
- Chloroform
|
|
κOR agonists
|
- 2-EMSB
- 2-MMSB
- Alazocine
- Bremazocine
- Butorphanol
- Cyclazocine
- Cyprenorphine
- Dextrallorphan
- Dezocine
- Enadoline
- Herkinorin
- HZ-2
- Ibogaine
- Ketazocine
- LPK-26
- Metazocine
- Nalbuphine
- Nalorphine
- Noribogaine
- Pentazocine
- Phenazocine
- Salvinorin A
- Spiradoline
- Tifluadom
- U-50488
- U-69,593
|
|
MAO inhibitors
|
- Harmaline
- Harmine
- Tetrahydroharmine
- Yohimbine
|
|
σR agonists
|
- DMT
- Dextrallorphan
- Dextromethorphan
- Dextrorphan
- Noscapine
|
|
Others
|
- Glaucine
- Isoaminile
- Pukateine
|
|
|
Cholinergics
|
|
Receptor ligands
|
|
mAChR
|
- Agonists: 77-LH-28-1
- AC-42
- AC-260,584
- Aceclidine
- Acetylcholine
- AF30
- AF150(S)
- AF267B
- AFDX-384
- Alvameline
- AQRA-741
- Arecoline
- Bethanechol
- Butyrylcholine
- Carbachol
- CDD-0034
- CDD-0078
- CDD-0097
- CDD-0098
- CDD-0102
- Cevimeline
- Choline
- cis-Dioxolane
- Ethoxysebacylcholine
- Itameline
- LY-593,039
- L-689,660
- LY-2,033,298
- McNA343
- Methacholine
- Milameline
- Muscarine
- NGX-267
- Ocvimeline
- Oxotremorine
- PD-151,832
- Pilocarpine
- RS86
- Sabcomeline
- SDZ 210-086
- Sebacylcholine
- Suberyldicholine
- Talsaclidine
- Tazomeline
- Thiopilocarpine
- Vedaclidine
- VU-0029767
- VU-0090157
- VU-0152099
- VU-0152100
- VU-0238429
- WAY-132,983
- Xanomeline
- YM-796
Antagonists: 3-Quinuclidinyl Benzilate
- 4-DAMP
- Aclidinium Bromide
- Anisodamine
- Anisodine
- Atropine
- Atropine Methonitrate
- Benactyzine
- Benzatropine/Benztropine
- Benzydamine
- BIBN 99
- Biperiden
- Bornaprine
- CAR-226,086
- CAR-301,060
- CAR-302,196
- CAR-302,282
- CAR-302,368
- CAR-302,537
- CAR-302,668
- CS-27349
- Cyclobenzaprine
- Cyclopentolate
- Darifenacin
- DAU-5884
- Dimethindene
- Dexetimide
- DIBD
- Dicyclomine/Dicycloverine
- Ditran
- EA-3167
- EA-3443
- EA-3580
- EA-3834
- Etanautine
- Etybenzatropine/Ethylbenztropine
- Flavoxate
- Himbacine
- HL-031,120
- Ipratropium bromide
- J-104,129
- Hyoscyamine
- Mamba Toxin 3
- Mamba Toxin 7
- Mazaticol
- Mebeverine
- Methoctramine
- Metixene
- N-Ethyl-3-Piperidyl Benzilate
- N-Methyl-3-Piperidyl Benzilate
- Orphenadrine
- Otenzepad
- Oxybutynin
- PBID
- PD-102,807
- PD-0298029
- Phenglutarimide
- Phenyltoloxamine
- Pirenzepine
- Piroheptine
- Procyclidine
- Profenamine
- RU-47,213
- SCH-57,790
- SCH-72,788
- SCH-217,443
- Scopolamine/Hyoscine
- Solifenacin
- Telenzepine
- Tiotropium bromide
- Tolterodine
- Trihexyphenidyl
- Tripitamine
- Tropatepine
- Tropicamide
- WIN-2299
- Xanomeline
- Zamifenacin; Others: 1st Generation Antihistamines (Brompheniramine
- chlorphenamine
- cyproheptadine
- dimenhydrinate
- diphenhydramine
- doxylamine
- mepyramine/pyrilamine
- phenindamine
- pheniramine
- tripelennamine
- triprolidine, etc)
- Tricyclic Antidepressants (Amitriptyline
- doxepin
- trimipramine, etc)
- Tetracyclic Antidepressants (Amoxapine
- maprotiline, etc)
- Typical Antipsychotics (Chlorpromazine
- thioridazine, etc)
- Atypical Antipsychotics (Clozapine
- olanzapine, etc.)
|
|
nAChR
|
- Agonists: 5-HIAA
- A-84,543
- A-366,833
- A-582,941
- A-867,744
- ABT-202
- ABT-418
- ABT-560
- ABT-894
- Acetylcholine
- Altinicline
- Anabasine
- Anatoxin-a
- AR-R17779
- Butinoline
- Butyrylcholine
- Carbachol
- Choline
- Cotinine
- Cytisine
- Decamethonium
- Desformylflustrabromine
- Dianicline
- Dimethylphenylpiperazinium
- Epibatidine
- Epiboxidine
- Ethanol
- Ethoxysebacylcholine
- EVP-4473
- EVP-6124
- Galantamine
- GTS-21
- Ispronicline
- Levamisole
- Lobeline
- MEM-63,908/RG-3487
- Morantel
- Nicotine
- NS-1738
- PHA-543,613
- PHA-709,829
- PNU-120,596
- PNU-282,987
- Pozanicline
- Rivanicline
- RJR-2429
- Sazetidine A
- Sebacylcholine
- SIB-1508Y
- SIB-1553A
- SSR-180,711
- Suberyldicholine
- Suxamethonium/Succinylcholine
- TC-1698
- TC-1734
- TC-1827
- TC-2216
- TC-5214
- TC-5619
- TC-6683
- Tebanicline
- Tropisetron
- UB-165
- Varenicline
- WAY-317,538
- XY-4083
Antagonists: 18-Methoxycoronaridine
- α-Bungarotoxin
- α-Conotoxin
- Alcuronium
- Amantadine
- Anatruxonium
- Atracurium
- Bupropion
- Chandonium
- Chlorisondamine
- Cisatracurium
- Coclaurine
- Coronaridine
- Dacuronium
- Decamethonium
- Dextromethorphan
- Dextropropoxyphene
- Dextrorphan
- Diadonium
- DHβE
- Dihydrochandonium
- Dimethyltubocurarine/Metocurine
- Dipyrandium
- Dizocilpine/MK-801
- Doxacurium
- Esketamine
- Fazadinium
- Gallamine
- Hexafluronium
- Hexamethonium/Benzohexonium
- Hydroxybupropion
- Ibogaine
- Isoflurane
- Ketamine
- Kynurenic acid
- Laudexium/Laudolissin
- Levacetylmethadol
- Malouetine
- Mecamylamine
- Memantine
- Methadone (Levomethadone)
- Methorphan/Racemethorphan
- Methyllycaconitine
- Metocurine
- Mivacurium
- Morphanol/Racemorphan
- Neramexane
- Nitrous Oxide
- Pancuronium
- Pempidine
- Pentamine
- Pentolinium
- Phencyclidine
- Pipecuronium
- Radafaxine
- Rapacuronium
- Rocuronium
- Surugatoxin
- Thiocolchicoside
- Toxiferine
- Trimethaphan
- Tropeinium
- Tubocurarine
- Vecuronium
- Xenon
|
|
|
|
Reuptake inhibitors
|
|
Plasmalemmal
|
CHT Inhibitors
|
- Hemicholinium-3/Hemicholine
- Triethylcholine
|
|
|
Vesicular
|
|
|
|
|
Enzyme inhibitors
|
|
Anabolism
|
ChAT inhibitors
|
- 1-(-Benzoylethyl)pyridinium
- 2-(α-Naphthoyl)ethyltrimethylammonium
- 3-Chloro-4-stillbazole
- 4-(1-Naphthylvinyl)pyridine
- Acetylseco hemicholinium-3
- Acryloylcholine
- AF64A
- B115
- BETA
- CM-54,903
- N,N-Dimethylaminoethylacrylate
- N,N-Dimethylaminoethylchloroacetate
|
|
|
Catabolism
|
AChE inhibitors
|
|
|
BChE inhibitors
|
- Cymserine * Many of the acetylcholinesterase inhibitors listed above act as butyrylcholinesterase inhibitors.
|
|
|
|
|
Others
|
|
Precursors
|
- Choline (Lecithin)
- Citicoline
- Cyprodenate
- Dimethylethanolamine
- Glycerophosphocholine
- Meclofenoxate/Centrophenoxine
- Phosphatidylcholine
- Phosphatidylethanolamine
- Phosphorylcholine
- Pirisudanol
|
|
Cofactors
|
- Acetic acid
- Acetylcarnitine
- Acetyl-coA
- Vitamin B5 (Pantethine
- Pantetheine
- Panthenol)
|
|
Others
|
- Acetylcholine releasing agents: α-Latrotoxin
- β-Bungarotoxin; Acetylcholine release inhibitors: Botulinum toxin (Botox); Acetylcholinesterase reactivators: Asoxime
- Obidoxime
- Pralidoxime
|
|
|
|
Witchcraft and magic
|
|
Types |
- African witchcraft
- Asian witchcraft
- Australasian witchcraft
- European witchcraft
- Akelarre
- Benandanti
- Brujería
- Cunning folk
- Seiðr
- Völva
- White witch
- Witch-cult hypothesis
- North American witchcraft
- 21 Divisiones
- Granny woman
- Hoodoo
- Huna
- Pow-wow
- Santería
- Vodou
- Voodoo
- South American witchcraft
- Contemporary witchcraft
- Feri Tradition
- Kitchen witchcraft
- Stregheria
- Wicca
|
|
Practices |
- Animism
- Coven
- Demon
- Divination
- Entheogen
- Evocation
- Familiar spirit
- Flying ointment
- Jinn
- Magic
- Necromancy
- Occultism
- Poppet
- Potions
- Prayer
- Satanic ritual abuse
- Satanism
- Shamanism
- Sigils
- Spiritism
- Spiritualism
- Witch ball
- Witch's ladder
|
|
Objects |
- Amulet
- Broom
- Cloak of invisibility
- Magic carpet
- Magic ring
- Magic sword
- Talisman
- Wand
|
|
Folklore and mythology |
- Agamede
- Aradia
- Baba Yaga
- Daayan
- Drude
- Elbow witch
- Huld
- Kalku
- Hecate
- Circe
- Medea
- Obayifo
- Sea witch
- Sorginak
- Spearfinger
- Three Witches
- Witch of Endor
|
|
Major historic treatises |
- Formicarius
- Malleus Maleficarum
- Summis desiderantes affectibus
|
|