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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/14 10:12:03」(JST)

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C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.^[1]^[2]

Function

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.^[2]

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.^[3] This receptor is normally expressed by melanocytes,^[4] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,^[5] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.^[6]

References

^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
^ ^a ^b "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10".
^ Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479.
^ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
^ Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607.
^ Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.

External links

"Chemokine Receptors: CCR10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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English Journal

TSLP Directly Interacts with Skin-Homing Th2 Cells Highly Expressing its Receptor to Enhance IL-4 Production in Atopic Dermatitis.

Tatsuno K1, Fujiyama T1, Yamaguchi H1, Waki M1, Tokura Y1.
The Journal of investigative dermatology.J Invest Dermatol.2015 Aug 19. doi: 10.1038/jid.2015.318. [Epub ahead of print]
Thymic stromal lymphopoietin (TSLP) is overtly expressed on skin lesions of atopic dermatitis (AD), and the initiative role of TSLP-activated DCs in AD has gained much attention in the past few years, while its actions on other immune cells such as T cells have been given less notice. We aimed to cl
PMID 26288354

T-helper 22 cells as a new player in chronic inflammatory skin disorders.

Mirshafiey A1, Simhag A2, El Rouby NM3, Azizi G4,5.
International journal of dermatology.Int J Dermatol.2015 Aug;54(8):880-8. doi: 10.1111/ijd.12883.
T-helper 22 (Th22) cell is a new subset of CD4(+) T cells that secrets interleukin (IL)-22 but not IL-17 or interferon-γ. Th22 is distinct from Th17 and other known CD4(+) T-cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR6(+) CCR4(+) CCR10(+)
PMID 26183243

Recruitment of IL-27-Producing CD4(+) T Cells and Effect of IL-27 on Pleural Mesothelial Cells in Tuberculous Pleurisy.

Ye ZJ1, Xu LL, Zhou Q, Cui A, Wang XJ, Zhai K, Wang Z, Tong ZH, Shi HZ.
Lung.Lung.2015 Aug;193(4):539-48. doi: 10.1007/s00408-015-9738-2. Epub 2015 May 6.
BACKGROUND: The numbers of IL-27-producing CD4(+) T cells and the concentration of soluble IL-27 have been found to be increased in tuberculous pleural effusion (TPE). The objective of the present study was to explore the mechanism by which IL-27(+)CD4(+) T cells are recruited into the pleural space
PMID 25944255

Japanese Journal

皮膚疾患におけるIL-22の役割

藤田英樹
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 35(3), 168-175, 2012-06-30
… トカインと考えられてきたが，近年IFN-γ, IL-4, IL-17を産生しない新しいIL-22産生CD4陽性T細胞サブセット（Th22）が発見され，注目されている．Th22細胞は皮膚にホーミングするためのケモカイン受容体であるCCR4とCCR10を発現するが，実際に正常皮膚に存在するとともに，炎症性皮膚疾患患者において末梢血と比べて皮膚病変内に多数見られることより，皮膚の恒常性の維持や皮膚疾患の病態形成に関わっているものと考えら …
NAID 10030832602

Differential patterns of CXCR3, CCR3, and CCR10 expression in mycosis fungoides, Sezary syndrome and CD30^+ lymphoproli-ferative disorders : Immunohistochemical study of 43 samples

SUGA Hiraku,SUGAYA Makoto,MIYAGAKI Tomomitsu,OHMATSU Hanako,FUJITA Hideki,ASANO Yoshihide,TADA Yayoi,KADONO Takafumi,SATO Shinichi
Journal of dermatological science 64(2), 142-144, 2011-11-01
NAID 10030893397

Erythrodermic cutaneous T-cell lymphoma : How to differentiate this rare disease from atopic dermatitis

MIYAGAKI Tomomitsu,SUGAYA Makoto
Journal of dermatological science 64(1), 1-6, 2011-10-01
NAID 10030892625

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★リンクテーブル★

リンク元	「GPR-2」
拡張検索	「CCR10受容体」「CCR10レセプター」「CCR10 receptor」
関連記事	「CCR」

「GPR-2」

Chemokine (C-C motif) receptor 10
Identifiers
Symbols	CCR10 ; GPR2
External IDs	OMIM: 600240 MGI: 1096320 HomoloGene: 7271 IUPHAR: 67 GeneCards: CCR10 Gene
Gene ontology
Molecular function	• G-protein coupled receptor activity; • C-C chemokine receptor activity;
Cellular component	• plasma membrane; • integral component of plasma membrane;
Biological process	• chemotaxis; • immune response; • G-protein coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • chemokine-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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