WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 24th letter of the Roman alphabet (同)x, ex

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Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing.

Huertas CS1, Carrascosa LG1, Bonnal S2, Valcárcel J3, Lechuga LM4.
Biosensors & bioelectronics.Biosens Bioelectron.2016 Apr 15;78:118-25. doi: 10.1016/j.bios.2015.11.023. Epub 2015 Nov 10.
Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression. Current methodologies for monitoring alternative splicing deman
PMID 26599481

Protective effect of Salacia oblonga against tobacco smoke-induced DNA damage and cellular changes in pancreatic β-cells.

Basu S1, Pant M1, Rachana R1.
Pharmaceutical biology.Pharm Biol.2016 Mar;54(3):458-64. doi: 10.3109/13880209.2015.1046083. Epub 2015 Sep 25.
CONTEXT: Tobacco smoking generates a tremendous amount of free radicals that induce oxidative stress (OS) in diabetics (pancreatic islet cells are defective). Salacia oblonga Wall. (Celastraceae) is a proven antioxidant and antidiabetic plant whose mechanism of action is yet to be explored.OBJECTIVE
PMID 25973644

Pro-apoptotic effects of splice-switching oligonucleotides targeting Bcl-x pre-mRNA in human glioma cell lines.

Li Z1, Li Q2, Han L1, Tian N3, Liang Q1, Li Y1, Zhao X1, Du C1, Tian Y1.
Oncology reports.Oncol Rep.2016 Feb;35(2):1013-9. doi: 10.3892/or.2015.4465. Epub 2015 Nov 30.
Alternative splicing is a near-ubiquitous phenomenon with important roles in human diseases, including cancers. Splice-switching oligonucleotides (SSOs) have emerged as a class of antisense therapeutics that modulate alternative splicing by hybridizing to the pre-mRNA splice site. The Bcl-x gene is
PMID 26718027

Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

He Wei,Wang Bin,Zhuang Yun,Shao Dong,Sun Kewen,Chen Jianping
Journal of Pharmacological Sciences 119(4), 341-348, 2012
… In additional studies, treatment of QBC939 cells with different concentrations (10, 40, 80 <I>μ</I>M) of berberine for 48 h resulted in a significant dose-dependent increase in apoptosis compared to the non-berberine–treated control, which was associated with an increased expression of pro-apoptotic protein Bax and decreased expression of anti-apoptotic proteins Bcl-2 and Bcl-xL. …
NAID 130001889296

SNX-2112, a Novel Hsp90 Inhibitor, Induces G2/M Cell Cycle Arrest and Apoptosis in MCF-7 Cells

WANG Shao-Xiang,JU Huai-Qiang,LIU Kai-Sheng,ZHANG Jia-Xuan,WANG Xiao,XIANG Yang-Fei,WANG Rui,LIU Jin-Yun,LIU Qiu-Ying,XIA Min,XING Guo-Wen,LIU Zhong,WANG Yi-Fei
Bioscience, biotechnology, and biochemistry 75(8), 1540-1545, 2011-08-23
… SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. … Downregulation of Bcl-2 and Bcl-xL, upregulation of Bax, cleavage of caspase-9 and poly (ADP-ribose) polymerase (PARP), and degradation of the breast cancer-related Hsp90 client proteins human epidermal growth factor receptor-2 (HER2), Akt, Raf-1, and nuclear factor kappa-B kinase (IKK) were observed in SNX-2112 treated cells by Western blot assay. …
NAID 10029591607

B-Cell Lymphoma-2 Over-Expression Protects .DELTA.-Elemene-Induced Apoptosis in Human Lung Carcinoma Mucoepidermoid Cells via a Nuclear Factor Kappa B-Related Pathway

Xie Chun Ying,Yang Wei,Ying Jun,Ni Qing Chun,Pan Xue Diao,Dong Jin Hua,Li Karen,Wang Xi Sha
Biological and Pharmaceutical Bulletin 34(8), 1279-1286, 2011
… We examined whether δ-elemene could affect apoptosis in human lung carcinoma mucoepidermoid NCI-H292 cells, and test whether and how the over-expression of B-cell lymphoma-2 (Bcl-2) and B-cell lymphoma extra large (Bcl-xL) could off-set the effect of δ-elemene on cell growth. …
NAID 130000936599