参考

1.

http://dominoweb.dojindo.co.jp/goodsr7.nsf/codelist/B019?OpenDocument

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/31 20:47:52」(JST)

BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) is a calcium-specific aminopolycarboxylic acid. The presence of four carboxylic acid functional groups makes possible the binding of two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions.

There is a range of reported values for the dissociation constant of BAPTA, though 0.2 µM appears consistently.^[1] The rate constant for calcium binding is 500 µM⁻¹ s⁻¹.^[1]

References

^ ^a ^b Ricci AJ, Wu YC, Fettiplace R (15 October 1998). "The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.". The Journal of Neuroscience 18 (20): 8261–77. PMID 9763471.

English Journal

Orexin facilitates GABAergic IPSCs via postsynaptic OX receptors coupling to the intracellular PKC signalling cascade in the rat cerebral cortex.

Usui M, Kaneko K, Oi Y, Kobayashi M.
Neuropharmacology. 2019 May;149()97-112.
Orexin has multiple physiological functions including wakefulness, appetite, nicotine intake, and nociception. The cerebral cortex receives abundant orexinergic projections and expresses both orexinergic receptor 1 (OXR) and 2 (OXR). However, little is known about orexinergic regulation of GABA-medi
PMID 30763655

PKA- and Ca-dependent p38 MAPK/CREB activation protects against manganese-mediated neuronal apoptosis.

Zhu G, Liu Y, Zhi Y, Jin Y, Li J, Shi W, Liu Y, Han Y, Yu S, Jiang J, Zhao X.
Toxicology letters. 2019 Apr;().
Although manganese (Mn) is an essential trace element, its excessive consumption may lead to neuronal death and neurodegenerative disorders. Human cells launch adaptive responses to attenuate Mn-induced neurotoxicity. However, the regulation of the responsive proteins and their function during Mn-st
PMID 30951808

Effect of Selective Serotonin (5-HT) Receptor Agonist BW723C86 on Epidermal Growth Factor/Transforming Growth Factor-α Receptor Tyrosine Kinase and Ribosomal p70 S6 Kinase Activities in Primary Cultures of Adult Rat Hepatocytes.

Naito K, Kurihara K, Moteki H, Kimura M, Natsume H, Ogihara M.
Biological & pharmaceutical bulletin. 2019 Apr;42(4)631-637.
Serotonin (5-hydroxytryptamine; 5-HT) can induce hepatocyte DNA synthesis and proliferation by autocrine secretion of transforming growth factor (TGF)-α through 5-HT receptor/phospholipase C (PLC)/Ca and a signaling pathway involving epidermal growth factor (EGF)/TGF-α receptor tyrosine kinase (RT
PMID 30713268

Japanese Journal

Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration.

Glia 63(10), 1870-1882, 2015-10
NAID 120005674645

Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes

The Journal of Toxicological Sciences 40(4), 469-477, 2015
NAID 130005087446

Stereoisomer-Specific Anticancer Activities of Ginsenoside Rg3 and Rh2 in HepG2 Cells: Disparity in Cytotoxicity and Autophagy-Inducing Effects Due to 20(<i>S</i>)-Epimers

Biological and Pharmaceutical Bulletin 38(1), 102-108, 2015
NAID 130004872221

「ビス2アミノフェニルエチレングリコール四酢酸」

BAPTA
Names
	IUPAC name 1,2-bis(o-aminophenoxy)ethane- N,N,N',N'-tetraacetic acid
Identifiers
CAS Registry Number	85233-19-8
ChEBI	CHEBI:60888
ChemSpider	94562
	InChI InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32) ; Key: FTEDXVNDVHYDQW-UHFFFAOYSA-N ; InChI=1/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32); Key: FTEDXVNDVHYDQW-UHFFFAOYAD ;
Jmol-3D images	Image
PubChem	104751
	SMILES O=C(O)CN(c2ccccc2OCCOc1ccccc1N(CC(=O)O)CC(=O)O)CC(=O)O ;
Properties
Chemical formula	C22H24N2O10
Molar mass	476.433
Density	1.494 g/cm3
Melting point	177 to 179 °C (351 to 354 °F; 450 to 452 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is: /?)
	Infobox references

BAPTA
	IUPAC名 1,2-bis(o-aminophenoxy)ethane- N,N,N',N'-tetraacetic acid
識別情報
CAS登録番号	85233-19-8
PubChem	104751
ChemSpider	94562
ChEBI	CHEBI:60888
	SMILES O=C(O)CN(c2ccccc2OCCOc1ccccc1N(CC(=O)O)CC(=O)O)CC(=O)O;
	InChI InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32) ; Key: FTEDXVNDVHYDQW-UHFFFAOYSA-N InChI=1/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32); Key: FTEDXVNDVHYDQW-UHFFFAOYAD;
特性
化学式	C22H24N2O10
モル質量	476.433
密度	1.494 g/cm3
融点	177–179 °C
	特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。

　　[★] 1,2-ビス(2-アミノフェノキシ)エタン-N,N,N',N'-四酢酸 1,2-bis(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid BAPTA

「1,2-bis(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid」

　　[★] BAPTA。1,2-ビス(2-アミノフェノキシ)エタン-N,N,N',N'-四酢酸

[pmid9763471-1] Ricci AJ, Wu YC, Fettiplace R (15 October 1998). "The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.". The Journal of Neuroscience 18 (20): 8261–77. PMID 9763471.

[pmid9763471-1] Ricci AJ, Wu YC, Fettiplace R (15 October 1998). "The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.". The Journal of Neuroscience 18 (20): 8261–77. PMID 9763471.

匿名

検索

案内

案内

BAPTA

参考

Wikipedia preview

wiki ja

脚注

関連項目

wiki en

See also

References

English Journal

Japanese Journal

Related Links

★リンクテーブル★

「ビス2アミノフェニルエチレングリコール四酢酸」

「1,2-bis(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid」