アクチノバシラス・アクチノミセタムコミタンス : 33 件
アクチノバチルス・アクチノミセタムコミタンス : 30 件
アクチノバシルス・アクチノミセテムコミタンス : 18 件
アクチノバチルス・アクチノミセテムコミタンス : 50 件

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/18 12:31:06」(JST)

wiki en

[Wiki en表示]

Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) is a Gram-negative, facultative nonmotile, rod-shaped oral commensal often found in association with localized aggressive periodontitis, a severe infection of the periodontium, although it is also associated with nonoral infections. Its role in periodontitis was first discovered by Danish-born periodontist Jørgen Slots, a professor of dentistry and microbiology at the University of Southern California School of Dentistry.

'Bacterium actinomycetem comitans' was described by Klinger (1912) as coccobacillary bacteria isolated together with Actinomyces from actinomycotic lesions of man. It was reclassified as Actinobacillus actinomycetemcomitans by Topley & Wilson (1929) and as Haemophilus actinomycetemcomitans by Potts et al. (1985). The species has attracted attention because of its association with localized aggressive periodontitis. ^[1]

Nomenclature

Recent studies have shown a phylogenetic similarity of A. actinomycetemcomitans and Haemophilus aphrophilus, H. paraphrophilus, and H. segnis, suggesting the new genus Aggregatibacter for them.^[1]

Importance

It is one of the bacteria that might be implicated in destructive periodontal disease. Although it has been found more frequently in localized aggressive periodontitis,^[2] prevalence in any population is rather high. It has also been isolated from actinomycotic lesions (mixed infection with certain Actinomyces species, in particular A. israelii). It possesses certain virulence factors that enable it to invade tissues, such as leukotoxin. It has also been isolated from women with bacterial vaginosis.^[3]

Virulence factors

Leukotoxin; kills PMNs and monocytes
Cytolethal distending toxin
Immunosuppression factors that inhibit blastogenesis, antibody production and activate T-suppressor cells
Inhibition of PMNs functions
Resistant to complement-mediated killing
Lipopolysaccharides
Surface antigens
Heat shock proteins
Antimicrobial resistance

A. actinomycetemcomitans serotypes

a strain, for example ATCC 29523, frequently in oral cavity, variable leukotoxin expression
b strain Y4, most frequently in localized aggressive periodontitis, leukotoxin expression
c strain ATCC 33384, low leukotoxin
serotypes d, e

References

^ ^a ^b Nørskov-Lauritsen N, Kilian M (September 2006). "Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates". Int. J. Syst. Evol. Microbiol. 56 (Pt 9): 2135–46. doi:10.1099/ijs.0.64207-0. PMID 16957111.
^ Slots J (January 1976). "The predominant cultivable organisms in juvenile periodontitis". Scand J Dent Res 84 (1): 1–10. doi:10.1111/j.1600-0722.1976.tb00454.x. PMID 1061986.
^ Africa, Charlene; Nel, Janske; Stemmet, Megan (2014). "Anaerobes and Bacterial Vaginosis in Pregnancy: Virulence Factors Contributing to Vaginal Colonisation". International Journal of Environmental Research and Public Health 11 (7): 6979–7000. doi:10.3390/ijerph110706979. ISSN 1660-4601.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 歯性感染症の疫学、病因、および臨床症状 epidemiology pathogenesis and clinical manifestations of odontogenic infections
2. 固有弁心内膜炎の抗菌療法 antimicrobial therapy of native valve endocarditis
3. 歯性感染症の合併症、診断、および治療 complications diagnosis and treatment of odontogenic infections
4. 頚部顔面の放線菌症 cervicofacial actinomycosis
5. 培養陰性感染性心内膜炎の疫学、微生物学、および診断 epidemiology microbiology and diagnosis of culture negative endocarditis

English Journal

Arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota.

Corrêa JD1, Saraiva AM1, Queiroz-Junior CM2, Madeira MF3, Duarte PM4, Teixeira MM5, Souza DG3, da Silva TA6.
Anaerobe.Anaerobe.2016 Jun;39:91-6. doi: 10.1016/j.anaerobe.2016.03.006. Epub 2016 Mar 18.
Rheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory disorders that cause bone loss. PD tends to be more prevalent and severe in RA patients. Previous experimental studies demonstrated that RA triggers alveolar bone loss similarly to PD. The aim of this study was to investigate
PMID 26996070

Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.

Wang C1,2, Kankaanpää J3,4,5,6, Kummu O3,4, Turunen SP3,4,7, Akhi R3,4,8, Bergmann U9, Pussinen P10, Remes AM11,12, Hörkkö S3,4.
Immunologic research.Immunol Res.2016 Jun;64(3):699-710. doi: 10.1007/s12026-015-8781-7.
Natural antibodies are predominantly antibodies of the IgM isotype present in the circulation of all vertebrates that have not been previously exposed to exogenous antigens. They are often directed against highly conserved epitopes and bind to ligands of varying chemical composition with low affinit
PMID 26786003

Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis.

Herbert BA1, Novince CM1, Kirkwood KL1,2.
Molecular oral microbiology.Mol Oral Microbiol.2016 Jun;31(3):207-27. doi: 10.1111/omi.12119. Epub 2015 Sep 22.
Aggregatibacter actinomycetemcomitans is a perio-pathogenic bacteria that has long been associated with localized aggressive periodontitis. The mechanisms of its pathogenicity have been studied in humans and preclinical experimental models. Although different serotypes of A. actinomycetemcomitans h
PMID 26197893

Japanese Journal

臨床研究・症例報告 Actinobacillus actinomycetemcomitansによる多発肝膿瘍,脾膿瘍,軟部組織膿瘍を生じた1例

中原康雄,後藤隆文,岩村喜信 [他]
小児科臨床 65(6), 1203-1207, 2012-06
NAID 40019254398

ユーカリ葉抽出物による日和見感染，歯周疾患，う蝕予防についての検討　重症心身障害児・者への口腔ケアのために

河瀬聡一朗,宮沢裕夫,平井要,金子仁子
松本歯学 38(1), 12-21, 2012-04-30
… pathogens of periodontal disease : Prevotella intermedia (ATCC 25611 strain ) , Prevotella nigrescens (ATCC 335663 strain), Actinobacillus actinomycetemcomitans (JCM 8577 strain), and Porphyromonas gingivalis (ATCC 49417 strain) ; …
NAID 120004631691

Related Pictures

★リンクテーブル★

リンク元	「HACEK」「アクチノバチルス・アクチノミセタムコミタンス」「アクチノバシラス・アクチノミセタムコミタンス」「A. actinomycetemcomitans」「アクチノバチルス・アクチノミセテムコミタンス」
関連記事	「Actinobacillus」「actinomycetemcomitans」

「HACEK」

Aggregatibacter actinomycetemcomitans
Scientific classification
Kingdom:	Bacteria
Phylum:	Proteobacteria
Class:	Gammaproteobacteria
Order:	Pasteurellales
Family:	Pasteurellaceae
Genus:	Aggregatibacter
Species:	actinomycetemcomitans
Binomial name
	Aggregatibacter actinomycetemcomitans; (Klinger, 1912)