English Journal
- Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents.
- Sharaf el dein O, Gallerne C, Brenner C, Lemaire C.SourceINSERM UMR-S 769, LabEx LERMIT, Université Paris-Sud 11, 5 rue J B Clement, Chatenay-Malabry, France. sharaf_os@hotmail.com
- Biochemical pharmacology.Biochem Pharmacol.2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
- A major clinical problem regarding antitumoral treatment with DNA cross-linking agents such as cisplatin (Cisp), mechlorethamine (HN2) or its derivative melphalan (MLP) is intrinsic or acquired resistance to therapy, which frequently results from a resistance to apoptosis induction. In this study, a
- PMID 22285227
- Complete loss of expression of the ANT1 gene causing cardiomyopathy and myopathy.
- Echaniz-Laguna A, Chassagne M, Ceresuela J, Rouvet I, Padet S, Acquaviva C, Nataf S, Vinzio S, Bozon D, Mousson de Camaret B.SourceDépartement de Neurologie, Hôpitaux Universitaires, Strasbourg cedex, France. andoni.echaniz-laguna@chru-strasbourg.fr
- Journal of medical genetics.J Med Genet.2012 Feb;49(2):146-50. doi: 10.1136/jmedgenet-2011-100504. Epub 2011 Dec 20.
- BACKGROUND: The ANT1 gene, encoding ADP/ATP translocase 1, was investigated in an adult patient with an autosomal recessive mitochondrial disorder characterised by congenital cataracts, hypertrophic cardiomyopathy, myopathy and lactic acidosis.METHODS AND RESULTS: ANT1 sequencing showed that the pat
- PMID 22187496
- Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism.
- Chevrollier A, Loiseau D, Reynier P, Stepien G.SourceCNRS, UMR6214, F-49000 Angers, France. archevrollier@chu-angers.fr
- Biochimica et biophysica acta.Biochim Biophys Acta.2011 Jun;1807(6):562-7. doi: 10.1016/j.bbabio.2010.10.008. Epub 2010 Oct 13.
- Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism. Human ANT presents four isoforms (ANT1-4), each with a specific expression depending on the natur
- PMID 20950584
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