English Journal

ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics.

Prabhu D1, Goldstein AC2, El-Khoury R3, Rak M4, Edmunds L1, Rustin P4, Vockley J5, Schiff M6.
Molecular genetics and metabolism reports.Mol Genet Metab Rep.2015 Jun 1;3:43-46.
Adenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts. In spite of ANT2 expression in fibroblasts, we observed no
PMID 26000237

IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.

Hubackova S1, Kucerova A1, Michlits G2, Kyjacova L1, Reinis M2, Korolov O2, Bartek J3, Hodny Z1.
Oncogene.Oncogene.2015 May 18. doi: 10.1038/onc.2015.162. [Epub ahead of print]
Cellular senescence provides a biological barrier against tumor progression, often associated with oncogene-induced replication and/or oxidative stress, cytokine production and DNA damage response (DDR), leading to persistent cell-cycle arrest. While cytokines such as tumor necrosis factor-alpha (TN
PMID 25982278

Evaluation of in vivo antitumor effects of ANT2 shRNA delivered using PEI and ultrasound with microbubbles.

Park DH1, Jung BK2, Lee YS1, Jang JY1, Kim MK1, Lee JK1, Park H3, Seo J4, Kim CW1.
Gene therapy.Gene Ther.2015 Apr;22(4):325-32. doi: 10.1038/gt.2014.120. Epub 2015 Jan 15.
Gene therapy using RNA interference can be directed against tumors through various strategies, but has been hindered owing to the inefficiency of non-viral delivery. To evaluate the antitumor effects of adenine nucleotide translocase-2 (ANT2) short hairpin RNA (shRNA) by intraperitoneal injection us
PMID 25588739

Japanese Journal

MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1

Journal of Clinical Biochemistry and Nutrition 57(2), 98-104, 2015
NAID 130005096226

MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1

Journal of Clinical Biochemistry and Nutrition advpub(0), 2015
NAID 130005087378

Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis

Cancer science 100(3), 457-464, 2009-03-10
NAID 10025143314

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