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English Journal

Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.

Tomicic MT, Aasland D, Nikolova T, Kaina B, Christmann M.SourceDepartment of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Apr 8. pii: S0167-4889(13)00130-4. doi: 10.1016/j.bbamcr.2013.03.029. [Epub ahead of print]
To counteract genotoxic stress, DNA repair functions are in effect. Most of them are constitutively expressed while some of them can be up-regulated depending on the level of DNA damage. In human cells, only few DNA repair functions are subject of induction following DNA damage, and thus there is a
PMID 23578789

Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations.

Kanoke A, Kanamori M, Kumabe T, Saito R, Watanabe M, Tominaga T.SourceDepartment of Neurosurgery, Tohoku University Graduate School of Medicine; and.
Journal of neurosurgery.J Neurosurg.2013 Apr;118(4):854-8. doi: 10.3171/2012.9.JNS112353. Epub 2012 Oct 19.
This patient presented with a rare case of metachronous, multicentric gliomas first manifesting as headache and nausea in 1983 when he was an 8-year-old boy. Computed tomography revealed a cerebellar tumor and the tumor was subtotally resected. The histological diagnosis was pilocytic astrocytoma, a
PMID 23082883

Secondary hematological malignancies associated with temozolomide in patients with glioma.

Momota H, Narita Y, Miyakita Y, Shibui S.SourceDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan (H.M., Y.N., Y.M., S.S.).
Neuro-oncology.Neuro Oncol.2013 Mar 21. [Epub ahead of print]
BackgroundThe alkylating agent temozolomide (TMZ) is widely used for the treatment of gliomas. Although reports of treatment-related myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) associated with TMZ are accumulating, it remains unclear whether T
PMID 23519741

Neuro-Sweet disease mimicking recurrent anaplastic astrocytoma associated with therapy-related myelodysplastic syndrome: A case report

Shimizu Yu,Watanabe Takuya,Nakada Mitsutoshi,Hayashi Yutaka,Hamaguchi Yasuhito,Sugimori Naomi,Hamada Jun-ichiro
Clinical Neurology and Neurosurgery xx(xx), xxxx-xxxx, 2012
NAID 120003959463

紺田衣里,平澤祐輔,長谷川敏男,池田志斈,高橋玄,坂本一博
Skin Cancer 26(1), 11-14, 2011
72歳，男。初診の約6ヵ月前から肛門部に腫瘍が出現し徐々に増大したため，2009年1月6日，当科を受診した。初診時，肛門部9時〜11時方向に15×20mm大，不整形で扁平隆起性の黒色結節がみられた。悪性黒色腫を疑い局所麻酔下で肛門部皮膚腫瘍切除生検術を施行し，病理組織学的に悪性黒色腫と診断した。肛門管側の断端が陽性であったため，腹会陰式直腸切断術（Miles手術）ならびに右鼠径リンパ節生検術を施行 …
NAID 130001480050