Lung cancer is a major health problem, and is considered one of the deadliest cancers in humans. It is refractory to current treatments, and the mechanisms of lung cancer are unknown. Long noncoding RNAs (lncRNAs) are involved in various biological processes and human diseases. However, the exact fu
Benzo[a]pyrene-7,8-diol-9,10-epoxide inhibits gap junction intercellular communication via phosphorylation of tumor progression locus 2 in WB-F344 rat liver epithelial cells.
Lee BK1, Chung MY, Lee KW.
Molecular carcinogenesis.Mol Carcinog.2015 May;54(5):351-8. doi: 10.1002/mc.22103. Epub 2013 Nov 19.
Benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), a major metabolite of benzo[a]pyrene, has been reported to function as a human carcinogen. However, the molecular mechanism of how B[a]PDE regulates signaling pathways during tumor promotion remains unclear. In this study, we investigated the effects o
Titanium dioxide Nanoparticles Provide Protection Against Polycyclic Aromatic Hydrocarbon BaP & Chrysene Induced Perturbation of DNA Repair Machinery: A Computational Biology Approach.
Dhasmana A1, Mohd Q, Jamal S, Gupta R, Siddiqui MH, Kesari KK, Wadhwa G, Khan S, Lohani M.
Biotechnology and applied biochemistry.Biotechnol Appl Biochem.2015 Apr 23. doi: 10.1002/bab.1388. [Epub ahead of print]
We examined the interaction of Polycyclic Hydrocarbons (PAHs) like Benzo-α-Pyrene (BaP), Chrysene and their metabolites 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene,9,10-oxide (BPDE) & Chrysene1,2-diol-3,4-epoxide-2 (CDE), with the enzymes involved in DNA repair. We investigated interaction of120 en
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