関: 膀胱癌

4-aminobiphenyl is an amine derivative of biphenyl. It is used to manufacture azo dyes. It is a known human carcinogen[2] and so it has been largely replaced by less toxic compounds. It is similar to benzidine.

参考

wikipedia en

http://en.wikipedia.org/wiki/4-Aminobiphenyl

chemical

http://www.scbt.jp/datasheet-216773-4-aminobiphenyl.html

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/20 12:55:31」(JST)

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[Wiki en表示]

4-Aminobiphenyl is an amine derivative of biphenyl. It is used to manufacture azo dyes. It is a known human carcinogen^[3] and so it has been largely replaced by less toxic compounds. It is similar to benzidine.

Occupational exposure limits

Country	Standard^[4]
Argentina	Confirmed human carcinogen
Australia	Prohibited, Carcinogen
Belgium	Skin
Bulgaria	Confirmed human carcinogen
Colombia	Confirmed human carcinogen
Finland	TWA 10 mg/m³short term 20 mg/m³ Skin, Carcinogen
France	VME 0.001 ppm (0.007 mg/m³) Continuous1 Carcinogen
Hungary	Ceiling concentration 10 mg/m³Carcinogen
Jordan	Confirmed human carcinogen
New Zealand	Carcinogen, Skin
Norway	TWA 0.1 mg/m³
Singapore	Confirmed human carcinogen
South Korea	Carcinogen, Skin
Sweden	Group A Carcinogen
Vietnam	Confirmed human carcinogen

References

^ ^a ^b ^c ^d ^e ^f ^g ^h "NIOSH Pocket Guide to Chemical Hazards #0025". National Institute for Occupational Safety and Health (NIOSH).
^ ^a ^b ^c ^d ^e Record of CAS RN 92-67-1 in the GESTIS Substance Database of the IFA, accessed on 8. April 2009
^ National Toxicology Program
^ "4-Aminodiphenyl". RTECS. National Institute for Occupational Safety and Health (NIOSH).

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English Journal

Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.

Wang S1, Bott D1, Tung A1, Sugamori KS1, Grant DM2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Jul;43(7):916-21. doi: 10.1124/dmd.115.063297. Epub 2015 Apr 28.
4-Aminobiphenyl (ABP), a prototypical aromatic amine carcinogen in rodents and humans, requires bioactivation to manifest its toxic effects. A traditional model of ABP bioactivation, based on in vitro enzyme kinetic evidence, had postulated initial N-hydroxylation by the cytochrome P450 isoform CYP1
PMID 25922528

Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay.

Guo X1, Heflich RH1, Dial SL1, Richter PA2, Moore MM3, Mei N4.
Mutagenesis.Mutagenesis.2015 May 22. pii: gev039. [Epub ahead of print]
Quantifying health-related biological effects, like genotoxicity, could provide a way of distinguishing between tobacco products. In order to develop tools for using genotoxicty data to quantitatively evaluate the risk of tobacco products, we tested five carcinogens found in cigarette smoke, 4-amino
PMID 26001754

N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.

Wang S1, Sugamori KS1, Tung A1, McPherson JP1, Grant DM2.
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2015 Apr;144(2):393-405. doi: 10.1093/toxsci/kfv006. Epub 2015 Jan 19.
4-Aminobiphenyl (ABP) is a trace component of cigarette smoke and hair dyes, a suspected human carcinogen and a potent rodent liver carcinogen. Postnatal exposure of mice to ABP results in a higher incidence of liver tumors in males than in females, paralleling the sex difference in human liver canc
PMID 25601990

Safety assessment of mainstream smoke of herbal cigarette.

Bak JH1, Lee SM1, Lim HB1.
Toxicological research.Toxicol Res.2015 Mar;31(1):41-8. doi: 10.5487/TR.2015.31.1.041.
Owing to the increase in price of cigarettes in Korea, herbal cigarettes have received increasing attention as a non-smoking aid; however, its safety has hardly been studied. We analyzed some of the toxic components in the mainstream smoke of herbal cigarettes, performed a mutagenicity test on smoke
PMID 25874032

Japanese Journal

Establishment of an Invasive Prostate Cancer Model in Transgenic Rats by Intermittent Testosterone Administration

Journal of Toxicologic Pathology 27(1), 43-49, 2014
NAID 130003382476

Activation of 4-aminobphenyl and DNA damage mediated by 5-lipoxygenase in human bronchial epithelial cells

日本毒性学会学術年会 39.2(0), AP-63, 2012
NAID 130005009225

ヒト細胞におけるアミノビフェニルDNA付加体の損傷乗り越えDNA合成を介した突然変異誘発

放射線生物研究 44(3), 274-284, 2009-09
NAID 40016838872

Establishment of a Method for Analyzing Translesion DNA Synthesis across a Single Bulky Adduct in Human Cells

Genes and environment : the official journal of the Japanese Environmental Mutagen Society 31(1), 24-30, 2009-02-20
NAID 110007138016

Related Pictures

Fájl:4-Aminobiphenyl structural formula V 2D Image | 4-Aminobiphenyl | C12H11N amine;4-Aminobiphenyl;(1,1'-biphenyl)-4 Aminobiphenyl-3-carbonitrile suppliers Description 4-aminobiphenyl structure.svg Aminobiphenyl- Learn Chemistry Skip to

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リンク元	「4-アミノビフェニル」「アミノビフェニル」

「4-アミノビフェニル」

4-Aminobiphenyl
Names
	Preferred IUPAC name [1,1'-Biphenyl]-4-amine
	Other names 4-Aminobiphenyl; 4-ABP; 4-Aminodiphenyl; p-Aminobiphenyl; p-Aminodiphenyl; 4-Phenylaniline
Identifiers
CAS Number	92-67-1
3D model (Jmol)	Interactive image
ChEBI	CHEBI:1784
ChEMBL	ChEMBL44201
ChemSpider	6835
ECHA InfoCard	100.001.980
KEGG	C10998
	InChI InChI=1S/C12H11N/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,13H2 Key: DMVOXQPQNTYEKQ-UHFFFAOYSA-N ; InChI=1/C12H11N/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,13H2 Key: DMVOXQPQNTYEKQ-UHFFFAOYAX ;
	SMILES c2c(c1ccc(N)cc1)cccc2 ;
Properties
Chemical formula	C12H11N
Molar mass	169.22
Appearance	white to purple crystals
Odor	floral
Density	1,16 g·cm−3
Melting point	52 to 54 °C (126 to 129 °F; 325 to 327 K)
Boiling point	302 °C (576 °F; 575 K)
Solubility in water	practically insoluble in water, soluble in alcohol, ether and chloroform
Vapor pressure	20 mbar (191 °C)
Hazards
Main hazards	potential occupational carcinogen
NFPA 704	1 2 0
Flash point	147 °C (297 °F; 420 K)
Autoignition; temperature	450 °C (842 °F; 723 K)
	US health exposure limits (NIOSH):
REL (Recommended)	carcinogen
IDLH (Immediate danger)	N.D.
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

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英: 4-aminobiphenyl
関: アミノビフェニル

参考

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