WordNet

the 15th letter of the Roman alphabet (同)o
the blood group whose red cells carry neither the A nor B antigens; "people with type O blood are universal donors" (同)type_O, group O

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Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Δ5-steroids.

Takasawa K1, Ono M, Hijikata A, Matsubara Y, Katsumata N, Takagi M, Morio T, Ohara O, Kashimada K, Mizutani S.
Clinical endocrinology.Clin Endocrinol (Oxf).2014 Jun;80(6):782-9. doi: 10.1111/cen.12394. Epub 2014 Jan 16.
CONTEXT: Classical 3β-hydroxysteroid dehydrogenase (3β-HSD) deficiency (3β-HSDD) is caused by loss-of-function mutations in the HSD3B2 gene encoding type II 3β-HSD, which has a key role in steroid biosynthesis, converting Δ5-steroids to Δ4-steroids in adrenal glands and gonads.PATIENT: A patie
PMID 24372086

Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17.

Mak PJ1, Gregory MC, Sligar SG, Kincaid JR.
Biochemistry.Biochemistry.2014 Jan 14;53(1):90-100. doi: 10.1021/bi4014424. Epub 2013 Dec 20.
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids. The activities of cytochrome P450c17 (CYP17) are essential in sex hormone biosynthesis, with severe developmental defects being a consequence of defi
PMID 24328388

Khatri Y1, Gregory MC1, Grinkova YV1, Denisov IG1, Sligar SG2.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Jan 3;443(1):179-84. doi: 10.1016/j.bbrc.2013.11.094. Epub 2013 Dec 2.
Cytochrome P450 CYP17A1 catalyzes a series of reactions that lie at the intersection of corticoid and androgen biosynthesis and thus occupies an essential role in steroid hormone metabolism. This multifunctional enzyme catalyzes the 17α-hydroxylation of Δ4- and Δ5-steroids progesterone and pregne
PMID 24299954