123I-メタヨードベンジルグアニジン 123I-MIBG
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English Journal
- Assessment of myocardial adrenergic innervation with a solid-state dedicated cardiac cadmium-zinc-telluride camera: first clinical experience.
- Gimelli A, Liga R, Giorgetti A, Genovesi D, Marzullo P.Author information Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124 Pisa, Italy.AbstractAIMS: To investigate the relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function obtained by means of a low-dose imaging protocol with a cadmium-zinc-telluride (CZT) dedicated camera.
- European heart journal cardiovascular Imaging.Eur Heart J Cardiovasc Imaging.2013 Dec 17. [Epub ahead of print]
- AIMS: To investigate the relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function obtained by means of a low-dose imaging protocol with a cadmium-zinc-telluride (CZT) dedicated camera.METHODS: Twenty-eight patients with or without ischaemic
- PMID 24351314
- Catecholamines influence myocardial 123I MIBG uptake in neuroblastoma patients.
- van der Palen RL, Bulten BF, Mavinkurve-Groothuis AM, Bellersen L, van Laarhoven HW, Kapusta L, de Geus-Oei LF.Author information Ben F. Bulten, Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre (internal postal code 756), P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, Tel. +31/243 61 40 48, Fax +31/243 61 89 42, E-mail: B.Bulten@nucmed.umcn.nl.AbstractAim: Cardiac 123I metaiodobenzylguanidine (MIBG) imaging can be influenced by several factors. We evaluated the relationship between catecholamine measurements and cardiac 123I MIBG uptake in neuroblastoma patients. Patients, methods:30 neuroblastoma patients were retrospectively assessed on cardiac 123I MIBG uptake and urinary catecholamine dopamine and metabolites, homovanillic acid (HVA) and vanillylmandelic acid (VMA). Cardiac 123I MIBG uptake was quantified by heart-to-mediastinum (H/M) ratios, which were calculated into standard deviation scores (SDS) using age-specific reference values. Results: In 17 (57%) and 12 patients (40%) H/M ratio measurements were below -1.0 and -2.0 SDS at diagnosis. A significant inverse correlation between the average of urine metabolites HVA and VMA, and H/M ratio SDS was observed (r -.39, p = 0.04). Furthermore, there was a significant correlation between the urinary catecholamine metabolite HVA and H/M ratio SDS (r -.40, p=0.04). Conclusion: Routine calculation of H/M ratios in 123I MIBG scintigrams of neuroblastoma patients is not helpful because it will not identify cardiac ventricular dysfunction in this patient category. A low H/M ratio on 123I MIBG scintigraphy is explained by increased cathecholamine levels secreted by neuroblastoma tumours.
- Nuklearmedizin. Nuclear medicine.Nuklearmedizin.2013 Dec 13;52(6):228-34. doi: 10.3413/Nukmed-0590-13-05. Epub 2013 Sep 18.
- Aim: Cardiac 123I metaiodobenzylguanidine (MIBG) imaging can be influenced by several factors. We evaluated the relationship between catecholamine measurements and cardiac 123I MIBG uptake in neuroblastoma patients. Patients, methods:30 neuroblastoma patients were retrospectively assessed on cardiac
- PMID 24045423
- Association between left ventricular regional sympathetic denervation and mechanical dyssynchrony in phase analysis: a cardiac CZT study.
- Gimelli A, Liga R, Genovesi D, Giorgetti A, Kusch A, Marzullo P.Author information Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy, gimelli@ftgm.it.AbstractPURPOSE: To evaluate the relationships among myocardial sympathetic innervation, perfusion and mechanical synchronicity assessed with cardiac cadmium-zinc-telluride (CZT) scintigraphy.
- European journal of nuclear medicine and molecular imaging.Eur J Nucl Med Mol Imaging.2013 Dec 6. [Epub ahead of print]
- PURPOSE: To evaluate the relationships among myocardial sympathetic innervation, perfusion and mechanical synchronicity assessed with cardiac cadmium-zinc-telluride (CZT) scintigraphy.METHODS: A group of 29 patients underwent an evaluation of myocardial perfusion with 99mTc-tetrofosmin CZT scintigra
- PMID 24310439
Japanese Journal
- Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-tomediastinum ratios to overcome camera-collimator variations
- Nakajima Kenichi,Okuda Koichi,Yoshimura Mana,Matsuo Shinro,Wakabayashi Hiroshi,Imanishi Yasuhiro,Kinuya Seigo
- Journal of Nuclear Cardiology 21(5), 970-978, 2014-10
- … Background The heart-to-mediastinum ratio (HMR) of 123I-metaiodobenzylguanidine (MIBG) showed variations among institutions and needs to be standardized among various scinticamera-collimator combinations. …
- NAID 120005478674
- A prediction model for 5-year cardiac mortality in patients with chronic heart failure using 123I-metaiodobenzylguanidine imaging
- Nakajima Kenichi,Nakata Tomoaki,Yamada Takahisa,Yamashina Shohei,Momose Mitsuru,Kasama Shu,Matsui Toshiki,Matsuo Shinro,Travin Mark I.,Jacobson Arnold F.
- European Journal of Nuclear Medicine and Molecular Imaging 41(9), 1673-1682, 2014-09
- … A total of 933 CHF patients who underwent 123I-metaiodobenzylguanidine (MIBG) imaging and whose 5-year outcomes were known were selected from this database. …
- NAID 120005440314
- 123I-MIBG心筋シンチグラフィにおける心縦隔比と洗い出し率の解析方法と再現性の検討
- 長谷川 大輔,大西 英雄,松友 紀和 [他],甲谷 理温
- 日本放射線技術学会雑誌 70(12), 1420-1428, 2014
- … Purpose: The aim of this study was to investigate an appropriate analysis method and multicenter reproducibility of heart-to-mediastinum ratio (H/M) and washout rate (WR) in iodine-123-labeled metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy with a phantom. …
- NAID 130004776282
Related Links
- OBJECTIVE: We assessed the lesion detectability of low-dose diagnostic 123I-metaiodobenzylguanidine (MIBG) whole-body scans obtained at 6 and 24 h compared with posttreatment 131I-MIBG whole-body scans in malignant ...
- 123I metaiodobenzylguanidine (MIBG) is a radiopharmaceutical used for imaging neural crest tumours. The possibility of using 123I MIBG for imaging retinoblastomas has been assessed in this pilot study. Ten patients were studied ...
Related Pictures
★リンクテーブル★
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- 英
- 123I-metaiodobenzylguanidine, 123I-MIBG
- 商
- ミオMIBG-I123
- 関
- 心筋交感神経シンチグラフィ。メタヨードベンジルグアニジン、123I-MIBGシンチグラフィ, 131I-MIBG
- 半減期:13時間
- MIBGはノルエピネフリンと構造が類似している。
- 123I-MIBGは心シンチグラフィに用いられる。
- 心臓交感神経終末から取り込まれ、貯蔵顆粒に取り込まれる
- →心臓における交感神経の機能を見る。
参考
- http://halibm.digi2.jp/123I-MIBG.htm
- http://www.treatneuro.com/archives/1263
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メタヨードベンジルグアニジン MIBG
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123I-メタヨードベンジルグアニジン