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1. 造血幹細胞の概要overview of hematopoietic stem cells [show details]
…as thalassemia major), hematopoiesis may return to its former sites in the liver, spleen, and lymph nodes and may also be found in the adrenal glands, cartilage, adipose tissue, thoracic paravertebral …
2. 未確定の潜在能をもつクローン性造血（CHIP）とクローン性造血の関連疾患clonal hematopoiesis of indeterminate potential chip and related disorders of clonal hematopoiesis [show details]
… Clonal hematopoiesis (CH) refers to a genetically distinct subpopulation of myeloid cells that share an acquired (ie, not inherited) mutation, which distinguishes them from other tissues and unaffected …
3. 原発性骨髄線維症の臨床症状および診断clinical manifestations and diagnosis of primary myelofibrosis [show details]
…increase in lactate dehydrogenase may result from ineffective hematopoiesis, hyperuricemia is due to enhanced turnover of hematopoietic tissue and can cause gout or uric acid stones, and the increase in …
4. 骨髄造血の制御regulation of myelopoiesis [show details]
… of synovial tissue with leukocytes that release TNF, IL-6, GM-CSF, and other cytokines into the tissues. This response attracts other inflammatory cells that mediate tissue damage .… myeloid cells (granulocytes and monocytes) is a tightly regulated process. During steady-state hematopoiesis, approximately 10⁸ to 10⁹ of these cells are produced per hour in the bone marrow …
5. 心血管疾患の危険因子の概要overview of possible risk factors for cardiovascular disease [show details]
…risk factor for mortality in patients with heart failure, where it may be a reflection of decreased tissue perfusion. Serum ceramides (the combination of sphingosine and a fatty acid) are being investigated … The term "clonal hematopoiesis of indeterminate potential" (CHIP) is used to describe…