- 英
- loss of heterozygosity LOH, allelic loss
- 同
- ヘテロ接合性欠損、ヘテロ接合性喪失
- 関
参考1
- Loss of heterozygosity (LOH) in a cell represents the loss of normal function of one allele of a gene in which the other allele was already inactivated. This term is mostly used in the context of oncogenesis; after an inactivating mutation in one allele of a tumor suppressor gene occurs in the parent's germline cell, it is passed on to the zygote resulting in an offspring that is heterozygous for that allele. In oncology, loss of heterozygosity occurs when the remaining functional allele in a somatic cell of the offspring becomes inactivated by mutation. This results in no normal tumor suppressor being produced and this could result in tumorigenesis.
参考
- http://en.wikipedia.org/wiki/Loss_of_heterozygosity
UpToDate Contents
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Japanese Journal
- PP119023 食道扁平上皮癌における17qのヘテロ接合性欠失の意義
- 松本 祐介,松原 長秀,猶本 良夫,白川 靖博,尾崎 和秀,神原 健,中川 仁志,笹本 博美,永坂 岳司,細川 正夫,清水 憲二,磯崎 博司,田中 紀章
- 日本消化器外科学会雑誌 34(7), 1045, 2001-07-01
- NAID 110001342384
- 303 胃癌症例における第18番染色体長腕対立遺伝子のヘテロ接合性欠失と癌進展及び予後との検討(<特集>第47回日本消化器外科学会総会)
- 井上 徳司,内野 眞也,宮原 正樹,大澤 直文,下田 勝広,白石 憲男,尾迫 俊克,北野 正剛,小林 迪夫
- 日本消化器外科学会雑誌 29(2), 404, 1996-02-01
- NAID 110001321811
Related Pictures
★リンクテーブル★
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ヘテロ接合性欠失 loss of heterozygosity
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ヘテロ接合性欠失 LOH
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- 英
- conjugative
- 関
- 抱合性
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- 英
- hetero
- 関
- 異質