voltage-dependent sodium channel

出典: meddic

Nav channelvoltage-dependent Na+ channelvoltage-gated Na+ channelvoltage-gated sodium channel

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/02/21 23:48:40」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.


  • The role of cyclophilin D in interspecies differences in susceptibility to hepatotoxic drug-induced mitochondrial injury.
  • Sekine S, Kimura T, Motoyama M, Shitara Y, Wakazono H, Oida H, Horie T.SourceLaboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
  • Biochemical pharmacology.Biochem Pharmacol.2013 Nov 15;86(10):1507-14. doi: 10.1016/j.bcp.2013.08.027. Epub 2013 Sep 3.
  • Test compound A ((5Z)-6-[(2R,3S)-3-({[(4-Chloro-2-methylphenyl)sulfonyl]amino}methyl) bicyclo[2.2.2]oct-2-yl]hex-5-enoic acid) was withdrawn from premarketing clinical trials due to severe liver injury. Intracellular accumulation of lipids (steatosis) has been observed in human-derived cells and may
  • PMID 24012842
  • Altered PKA modulation in the Nav1.1 epilepsy variant I1656M.
  • Liu S, Zheng P.SourceState Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China.
  • Journal of neurophysiology.J Neurophysiol.2013 Nov;110(9):2090-8. doi: 10.1152/jn.00921.2012. Epub 2013 Aug 14.
  • Genetic epilepsy with febrile seizures plus (GEFS(+)) is an inherited epilepsy that can result from mutations in at least four ion channel subunits. The majority of the known GEFS(+) mutations have been identified in SCN1A, the gene encoding Nav1.1 α-subunit. Protein kinases as critical modulators
  • PMID 23945787
  • The effect of lamotrigine on nav1.4 voltage-gated sodium channels.
  • Nakatani Y, Masuko H, Amano T.SourceDepartment of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare, Japan.
  • Journal of pharmacological sciences.J Pharmacol Sci.2013 Oct 19;123(2):203-6. Epub 2013 Oct 4.
  • Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na(+) current using HEK293 cells expressing mouse Nav1.4
  • PMID 24096830


  • 微生物に学ぶアルカリ性環境適応戦略(セミナー「生物のストレス受容のメカニズム-分子レベルから細胞レベルまで-」)
  • 伊藤 政博
  • 低温生物工学会誌 57(1), 25-32, 2011-04-15
  • … In alkaliphilic Bacillus, Na^+-dependent pH homeostasis involves the Na^+/H^+ antiport activities as well as Na^+ re-entry routes. … A predominant role was evident for the NaChBac (voltage-dependent) Na channel of alkaliphilic B. …
  • NAID 110008671117
  • Comparative Study on the Actions of Toxin Extracts from Two Different Puffer Fishes on INa and Respiratory N-M Transmission in the Rat
  • Yamamoto Sokatsu,Yoshimura Megumi,Iwata Satomi,Matsuura Tatsuya,Shin Min-Chul,Yamaga Toshitaka,Ito Yushi,Akaike Norio,山元 総勝,吉村 恵,岩田 暁美,松浦 辰也,申 敏哲,山鹿 敏臣,伊東 祐之,赤池 紀生,ヤマモト ソウカツ,ヨシムラ メグミ,イワタ サトミ,マツウラ タツヤ,シン ミンチョル,ヤマガ トシタカ,イトウ ユウシ,アカイケ ノリオ
  • 福岡医学雑誌 101(8), 173-181, 2010-08-25
  • … We performed a comparative study on the effects of toxin extracts prepared from muscle and liver of two different puffer fishes on voltage dependent sodium current (INa), and compared the results with that of tetrodotoxin (TTX). …
  • NAID 120002646787


Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na) through a cell's ... In excitable cells such as neurons , myocytes, and certain types of glia, sodium channels are responsible for the rising ...
24 Feb 2003 ... Selective permeation of sodium ions through voltage-dependent sodium channels is fundamental to the generation of action potentials in excitable cells such as neurons. These channels are large integral membrane proteins ...


Voltage-gated sodium channels as Sodium Channel Classification and Voltage Gated Sodium Ion Channel  on insect voltage-gated sodium channelsSodium Ion Channelsodium channels play a central role in the

リンク元電位依存性ナトリウムチャネル」「voltage-gated Na+ channel」「Nav channel


  [★] 電位依存性ナトリウムチャネル



voltage-dependent sodium channel

  • 一つのサブユニットがチャネルを構成している (SP.77) ←αサブユニット。調整的な役割はβサブユニットが担う (SP.100)
6回膜貫通部分のうち、2つはポア形成に、4つは膜電位センサーとして働く (SP.77)
αサブユニット:9種類 (SP.100)
βサブユニット:4種類 (SP.100)

voltage-gated Na+ channel」


voltage-dependent Na+ channelvoltage-dependent sodium channelvoltage-gated sodium channel

Nav channel」


voltage-dependent Na+ channelvoltage-dependent sodium channel



  • n.
  • 川床、川底。水路、河道
  • 海峡
  • 水管、導管
  • 経路、ルート。道筋、方向
ion channelionic channel

WordNet   license wordnet

「direct the flow of; "channel information towards a broad audience"」
canalize, canalise

WordNet   license wordnet

「a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels"」
television channel, TV channel

WordNet   license wordnet

「a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"」

WordNet   license wordnet

「(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms"」
communication channel, line

WordNet   license wordnet

「a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company"」
transmission channel

WordNet   license wordnet

「a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"」

PrepTutorEJDIC   license prepejdic

「〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す」



  • adj.
  • 依存性の、依存的な、依存型の、依存の

WordNet   license wordnet

「relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"」

PrepTutorEJDIC   license prepejdic

「『頼っている』,依存している,従属している / 扶養される人(家族)」

WordNet   license wordnet

「addicted to a drug」
dependant, drug-addicted, hooked, strung-out

WordNet   license wordnet

「contingent on something else」
dependant, qualified

WordNet   license wordnet

「(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence"」


  [★] ナトリウム

WordNet   license wordnet

「a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt)」
Na, atomic number 11

PrepTutorEJDIC   license prepejdic




  • n.
electric potentialelectrical potentialpotential

WordNet   license wordnet

「the rate at which energy is drawn from a source that produces a flow of electricity in a circuit; expressed in volts」
electromotive force, emf

PrepTutorEJDIC   license prepejdic



  [★] チャネル

WordNet   license wordnet

「official routes of communication; "you have to go through channels"」