出典: meddic


WordNet   license wordnet

「an ACE inhibiting drug (trade name Mavik) used in some patients after a heart attack or to treat hypertension」

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/22 19:33:18」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.


  • Impurity profiling of trandolapril under stress testing: Structure elucidation of by-products and development of degradation pathway.
  • Dendeni M, Cimetiere N, Amrane A, Hamida NB.SourceLaboratoire de Chimie Analytique et Electrochimie, Faculté des Sciences de Tunis, Campus universitaire de Tunis El Manar, 2092 Tunis, Tunisia; Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Av. du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France; Université européenne de Bretagne, 35000 Rennes, France.
  • International journal of pharmaceutics.Int J Pharm.2012 Nov 15;438(1-2):61-70. doi: 10.1016/j.ijpharm.2012.08.048. Epub 2012 Sep 1.
  • Various regulatory authorities like International Conference on Harmonization (ICH), US Food and Drug Administration, Canadian Drug and Health Agency are emphasizing on the purity requirements and the identification of impurities in active pharmaceutical drugs. Qualification of the impurities is the
  • PMID 22960502
  • Glomerular Hyperfiltration and Renal Disease Progression in Type 2 Diabetes.
  • Ruggenenti P, Porrini EL, Gaspari F, Motterlini N, Cannata A, Carrara F, Cella C, Ferrari S, Stucchi N, Parvanova A, Iliev I, Dodesini AR, Trevisan R, Bossi A, Zaletel J, Remuzzi G; for the GFR Study Investigators.SourceCorresponding author: Piero Ruggenenti,
  • Diabetes care.Diabetes Care.2012 Oct;35(10):2061-2068. Epub 2012 Jul 6.
  • OBJECTIVE To describe the prevalence and determinants of hyperfiltration (glomerular filtration rate [GFR] ≥120 mL/min/1.73 m(2)), GFR decline, and nephropathy onset or progression in type 2 diabetic patients with normo- or microalbuminuria. RESEARCH DESIGN AND METHODS We longitudinally studied 6
  • PMID 22773704


  • Changes of Matrix Metalloproteinase-9 Level Is Associated With Left Ventricular Remodeling Following Acute Myocardial Infarction Among Patients Treated With Trandolapril, Valsartan or Both
  • MIYAZAKI Sakiko,KASAI Takatoshi,MIYAUCHI Katsumi,MIYAZAKI Tadashi,AKIMOTO Yoshinori,TAKAGI Atsutoshi,AIHARA Kouichiro,KAWAMURA Masaki,SUWA Satoru,KOJIMA Satoshi,SUMIYOSHI Masataka,DAIDA Hiroyuki
  • Circulation journal : official journal of the Japanese Circulation Society 74(6), 1158-1164, 2010-05-25
  • trandolapril, valsartan or a combination of both (half-dose-trandolapril plus half-dose-valsartan). … In comparison, across groups, it was found that MMP-9, LVEDVI and LVESVI at 12 months were significantly lower in the combination therapy group than in the trandolapril group. … There were no significant differences between the valsartan group and combination therapy group, or between the valsartan group and the trandolapril group. …
  • NAID 10026474742
  • 心疾患を合併する高血圧 JMIC-B,INVEST (大規模臨床試験--循環・代謝系を中心に) -- (高血圧)


Trandolapril is a prodrug that is deesterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin-angiotensin-aldosterone system. Trandolapril has a half life of about 6 hours, and trandolaprilat has a half life of ...
Trandolapril (Mavik) hypertension and CHF drug side effects, dosage, drug interactions, and patient safety information.