thrombin-activatable fibrinolysis inhibitor

出典: meddic


Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/28 06:29:23」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.


  • Effect of single nucleotide polymorphism in thrombin-activatable fibrinolysis inhibitor on the risk of diabetic macrovascular disease.
  • Zheng C1, Li X, Kong C, Ke S, Peng C, Cui T, Gao M, Zhou Y, Guo W, Huang L, Petersen RB, Huang K.
  • Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2014 Nov 13. [Epub ahead of print]
  • Hypofibrinolysis is commonly found in patients with diabetes mellitus and is associated with the increased risk for many diabetic complications. An important inhibitor of fibrinolysis, thrombin-activatable fibrinolysis inhibitor (TAFI), participates in hypofibrinolysis in diabetes mellitus and may b
  • PMID 25396763
  • Effects of a TAFI-Inhibitor Combined with a Suboptimal Dose of rtPA in a Murine Thromboembolic Model of Stroke.
  • Durand A1, Chauveau F, Cho TH, Kallus C, Wagner M, Boutitie F, Maucort-Boulch D, Berthezène Y, Wiart M, Nighoghossian N.
  • Cerebrovascular diseases (Basel, Switzerland).Cerebrovasc Dis.2014 Nov 13;38(4):268-275. [Epub ahead of print]
  • Background: Since thrombolysis is the only approved intervention for ischemic stroke, improving its efficacy and safety is a therapeutic aim of considerable interest. The activated form of thrombin activatable fibrinolysis inhibitor (TAFI) has antifibrinolytic effects, and inhibition of TAFI might t
  • PMID 25401979
  • Antifibrinolytic mechanisms in acute airway injury after sulfur mustard analog inhalation.
  • Rancourt RC1, Ahmad A, Veress LA, Rioux JS, Garlick RB, White CW.
  • American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2014 Oct;51(4):559-67. doi: 10.1165/rcmb.2014-0012OC.
  • Acute lung injury in response to mustard gas (sulfur mustard [SM]) inhalation results in formation of fibrin casts, which obstruct the airway. The objective of this study was to identify fibrinolytic pathways that could be contributing to the persistence of airway casts after SM exposure. Rats were
  • PMID 24796565


  • TAFI の構造と機能
  • 三浦 徳,細野 崇,関 泰一郎
  • 日本血栓止血学会誌 25(4), 512-515, 2014
  • Points①TAF(I 56 kDa)は,活性化ペプチド(Phe1-Arg92; 20 kDa)と触媒ドメイン(Ala93-Val401; 36 kDa)から構成されている.②活性化ペプチドは,4 つのβシートと2 つのαヘリックスからなるα/βサンドイッチ構造(Phe1-Val76),部分的にαヘリックス構造を形成したリンカー領域(Gln77-Arg92)に分けられる.③トロンビンはArg92 …
  • NAID 130004687767
  • 話題のキーワード解説 TAFI(thrombin-activatable fibrinolysis inhibitor)
  • 一瀬 白帝
  • International review of thrombosis 5(4), 270-273,221, 2010-12
  • NAID 40018282870
  • Increase in plasma thrombin-activatable fibrinolysis inhibitor may not contribute to thrombotic tendency in antiphospholipid syndrome because of inhibitory potential of antiphospholipid antibodies toward TAFI activation
  • IEKO Masahiro,YOSHIDA Mika,NAITO Sumiyoshi,NAKABAYASHI Toru,KANAZAWA Kaoru,MIZUKAMI Kazuhiro,MUKAI Masaya,ATSUMI Tatsuya,KOIKE Takao
  • International journal of hematology 91(5), 776-783, 2010-06-15
  • … Objective: To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. … Methods and Results: Both the TAFI antigen (TAFI:Ag) level measured with an ELISA, and thrombin-thrombomodulin-dependent TAFI activity (TAFI:Ac) were elevated in 68 APS patients as compared with those in 66 healthy controls, though they were lower than those in 46 patients with autoimmune diseases. …
  • NAID 10026511025


1. Ann Med. 2006;38(6):378-88. Thrombin activatable fibrinolysis inhibitor (TAFI)--how does thrombin regulate fibrinolysis? Bouma BN, Mosnier LO. Department of Molecular and Experimental Medicine, The Scripps Research Institute ...
1. Crit Care Med. 2004 May;32(5 Suppl):S320-4. Thrombin activatable fibrinolysis inhibitor: not just an inhibitor of fibrinolysis. Bajzar L, Jain N, Wang P, Walker JB. McMaster University, Hamilton, Ontario, Canada. OBJECTIVE: To ...


Adv Neonatal Care 4(5):258-273, 2004  , their zymogens and inhibitor complexes Thrombin Activatable FibrinolyticFibrinolysis. TAFI = thrombin activatable coagulation factors factor Xa and thrombin A615 | Thrombin Activatable Fibrinolysis




  • v.
  • 抑制する、阻害する、阻止する

WordNet   license wordnet

「limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"」

PrepTutorEJDIC   license prepejdic

「〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》」

WordNet   license wordnet

「control and refrain from showing; of emotions, desires, impulses, or behavior」
bottle up, suppress

WordNet   license wordnet

「limit the range or extent of; "Contact between the young was inhibited by strict social customs"」



  • n.

WordNet   license wordnet

「a substance that retards or stops an activity」

PrepTutorEJDIC   license prepejdic

「抑制する人(物) / 化学反応抑制剤」



WordNet   license wordnet

「a normal ongoing process that dissolves fibrin and results in the removal of small blood clots; "drugs causing fibrinolysis have been utilized therapeutically"」


  [★] トロンビン

WordNet   license wordnet

「an enzyme that acts on fibrinogen in blood causing it to clot」



  • comb form.
  • 血栓、血栓症
  • ex.