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- 1. 止血の概要 overview of hemostasis
- 2. 血小板機能検査 platelet function testing
- 3. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
- 4. 補体系の後天性疾患 acquired disorders of the complement system
- 5. 体液性免疫応答 the humoral immune response
- TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.
- Fujii T1, Sakata A2, Nishimura S3, Eto K4, Nagata S5.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Sep 28. pii: 201516594. [Epub ahead of print]
- Phosphatidylserine (PtdSer) exposure on the surface of activated platelets requires the action of a phospholipid scramblase(s), and serves as a scaffold for the assembly of the tenase and prothrombinase complexes involved in blood coagulation. Here, we found that the activation of mouse platelets wi
- PMID 26417084
- Simulated Thrombin Generation in the Presence of Surface-Bound Heparin and Circulating Tissue Factor.
- Dydek EV1, Chaikof EL.
- Annals of biomedical engineering.Ann Biomed Eng.2015 Jul 14. [Epub ahead of print]
- An expanded computational model of surface induced thrombin generation was developed that includes hemodynamic effects, 22 biochemical reactions and 44 distinct chemical species. Surface binding of factors V, VIII, IX, and X was included in order to more accurately simulate the formation of the surf
- PMID 26168717
- Factor VIII organisation on nanodiscs with different lipid composition.
- Grushin K, Miller J, Dalm D, Stoilova-McPhie S1.
- Thrombosis and haemostasis.Thromb Haemost.2015 Apr;113(4):741-9. doi: 10.1160/TH14-09-0725. Epub 2015 Jan 15.
- Nanodiscs (ND) are lipid bilayer membrane patches held by amphiphilic scaffolding proteins (MSP) of ~10 nm in diameter. Nanodiscs have been developed as lipid nanoplatforms for structural and functional studies of membrane and membrane associated proteins. Their size and monodispersity have rendered
- PMID 25589466
- Extrinsic tenase complex is made up of tissue factor, factor VII, and Ca as an activating ion. Intrinsic tenase complex contains the active factor IX (IXa), its cofactor factor VIII (VIIIa), the substrate (factor X), and they are activated by negatively ...
- Heparin Inhibits the Intrinsic Tenase Complex by Interacting with an Exosite on. Factor IXa†. John P. Sheehan,* Catherine E. Kobbervig, and Heidi M. Kirkpatrick. Department of Medicine/Hematology, UniVersity of WisconsinsMadison, ...