免疫グロブリン代替軽鎖

WordNet

very thin and insubstantial; "thin paper"; "light summer dresses"
make lighter or brighter; "This lamp lightens the room a bit" (同)illume, illumine, light_up, illuminate
a condition of spiritual awareness; divine illumination; "follow Gods light" (同)illumination
having abundant light or illumination; "they played as long as it was light"; "as long as the lighting was good" (同)lighting
(physics) electromagnetic radiation that can produce a visual sensation; "the light was filtered through a soft glass window" (同)visible_light, visible_radiation
any device serving as a source of illumination; "he stopped the car and turned off the lights" (同)light_source
the visual effect of illumination on objects or scenes as created in pictures; "he could paint the lightest light and the darkest dark" (同)lightness
a particular perspective or aspect of a situation; "although he saw it in a different light, he still did not understand"
a person regarded very fondly; "the light of my life"
a visual warning signal; "they saw the light of the beacon"; "there was a light at every corner"
an illuminated area; "he stepped into the light"
mental understanding as an enlightening experience; "he finally saw the light"; "can you shed light on this problem?"
public awareness; "it brought the scandal to light"
(used of color) having a relatively small amount of coloring agent; "light blue"; "light colors such as pastels"; "a light-colored powder" (同)light-colored
moving easily and quickly; nimble; "the dancer was light and graceful"; "a lightsome buoyant step"; "walked with a light tripping step" (同)lightsome, tripping
having relatively few calories; "diet cola"; "light (or lite) beer"; "lite (or light) mayonnaise"; "a low-cal diet" (同)lite, low-cal, calorie-free
less than the correct or legal or full amount often deliberately so; "a light pound"; "a scant cup of sugar"; "regularly gives short weight" (同)scant, short
(of sleep) easily disturbed; "in a light doze"; "a light sleeper"; "a restless wakeful night" (同)wakeful
(physics, chemistry) not having atomic weight greater than average; "light water is ordinary water"
(used of soil) loose and large-grained in consistency; "light soil"
characterized by or emitting light; "a room that is light when the shutters are open"; "the inside of the house was airy and light"
demanding little effort; not burdensome; "light housework"; "light exercise"
designed for ease of movement or to carry little weight; "light aircraft"; "a light truck"
easily assimilated in the alimentary canal; not rich or heavily seasoned; "a light diet"
having little importance; "losing his job was no light matter"
intended primarily as entertainment; not serious or profound; "light verse"; "a light comedy"
not great in degree or quantity or number; "a light sentence"; "a light accent"; "casualties were light"; "light snow was falling"; "light misty rain"; "light smoke from the chimney"
of comparatively little physical weight or density; "a light load"; "magnesium is a light metal--having a specific gravity of 1.74 at 20 degrees C"
of little intensity or power or force; "the light touch of her fingers"; "a light breeze"
of the military or industry; using (or being) relatively small or light arms or equipment; "light infantry"; "light cavalry"; "light industry"; "light weapons"
psychologically light; especially free from sadness or troubles; "a light heart"
fasten or secure with chains; "Chain the chairs together"
a unit of length
a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
a linked or connected series of objects; "a chain of daisies"
a series of (usually metal) rings or links fitted into one another to make a flexible ligament
anything that acts as a restraint
(chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
(business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
connect or arrange into a chain by linking
someone who takes the place of another person (同)alternate, replacement
apparatus for supplying artificial light effects for the stage or a film
the craft of providing artificial light; "an interior decorator must understand lighting"
a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin

PrepTutorEJDIC

〈U〉『光,光線』;明るさ / 〈U〉夜明け;日中;日光 / 〈C〉『明かり』(太陽・灯火など光を出すもの) / 〈U〉《時にa~》光輝(brightness),(目などの)輝き / 〈C〉(点火するための)火,火花 / 〈C〉明かり採り,採光窓 / 〈C〉《通例単数形で》(絵などの)明るい部分 / 〈U〉(…についての)知識,情報,理解《+『on』+『名』》 / 〈C〉(ものを見る)観点,見地;相 / 〈C〉この世に光を与える人;指導的な人物 / …‘に'『火をつける』《+『up』+『名』+『名』+『up』》 / …‘に'『明かりをつける』,‘を'照らす《+『up』+『名,』+『名』+『up』》 / 〈人〉‘を'明かりをつけて案内する / 〈表情など〉‘を'明るくする《+『up』+『名,』+『名』+『up』》 / 〈物が〉火がつく,点火する;明かりがつく《+『up』》 / 明るくなる,晴れ晴れする《+『up』》 / 『明るい』 / (色が)『薄い』
(重量が)『軽い』 / (いろいろな事について,その程座・量が)軽い,小さい / 『軽快な』 / 軽装の / 肩のこらない;気軽な / 手軽な,骨の折れなし / (食べ物が)消化のよい,もたれない / ふらふらする,目まいのする / アルコール分の少ない / (パンなどが)ふんわりした / (重量が)軽く / (程度が)軽く,容易に;軽装で
(車・馬などから)降りる《+『from』+『名』》(alight) / (木などに)〈鳥などが〉止まる《+『on』(『upon』)+『名』》 / (…に)〈打撃・運などが〉突然ふりかかる《+『on』(『upon』)+『名』》
『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》
(…の)代理人;代用品《+of(for)+名》 / 《米》(ある州での)遺言検認判事
照明,点火 / 照明方法(装置)

UpToDate Contents

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1. 免疫グロブリン軽鎖（AL）アミロイドーシス（原発性アミロイドーシス）の臨床像、検査所見、および診断 clinical presentation laboratory manifestations and diagnosis of immunoglobulin light chain al amyloidosis primary amyloidosis
2. 免疫グロブリン軽鎖（AL）アミロイドーシスおよび軽鎖重鎖沈着症の病因 pathogenesis of immunoglobulin light chain al amyloidosis and light and heavy chain deposition diseases
3. 免疫遺伝学 immunoglobulin genetics
4. 免疫グロブリン軽鎖（AL）アミロイドーシスおよび軽鎖重鎖沈着症の予後および治療 prognosis and treatment of immunoglobulin light chain al amyloidosis and light and heavy chain deposition diseases
5. Pathogenesis and diagnosis of light chain cast nephropathy (myeloma kidney)

English Journal

Broad feedback inhibition of pre-B-cell receptor signaling components.

Hauser J, Verma-Gaur J, Grundström T.SourceDepartment of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden.
Molecular immunology.Mol Immunol.2013 Jan 11;54(3-4):247-253. doi: 10.1016/j.molimm.2012.12.002. [Epub ahead of print]
During B lymphocyte development, first immunoglobulin heavy chain gene segments and then immunoglobulin light chain gene segments are rearranged to create antibody diversity. Early in the development, expression of a pre-B-cell receptor (pre-BCR) that has membrane-bound Ig heavy chain protein associ
PMID 23318223

Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.

Elantak L, Espeli M, Boned A, Bornet O, Bonzi J, Gauthier L, Feracci M, Roche P, Guerlesquin F, Schiff C.SourceLaboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS UMR7255, Aix-Marseille Université, 13402 Marseille cedex 20, France.
The Journal of biological chemistry.J Biol Chem.2012 Dec 28;287(53):44703-13. doi: 10.1074/jbc.M112.395152. Epub 2012 Nov 2.
During B cell differentiation in the bone marrow, the expression and activation of the pre-B cell receptor (pre-BCR) constitute crucial checkpoints for B cell development. Both constitutive and ligand-dependent pre-BCR activation modes have been described. The pre-BCR constitutes an immunoglobulin h
PMID 23124203

New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes.

Palladini G, Dispenzieri A, Gertz MA, Kumar S, Wechalekar A, Hawkins PN, Schönland S, Hegenbart U, Comenzo R, Kastritis E, Dimopoulos MA, Jaccard A, Klersy C, Merlini G.SourceFondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Pavia, Italy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2012 Dec 20;30(36):4541-9. doi: 10.1200/JCO.2011.37.7614. Epub 2012 Oct 22.
PURPOSE: To identify the criteria for hematologic and cardiac response to treatment in immunoglobulin light chain (AL) amyloidosis based on survival analysis of a large patient population.PATIENTS AND METHODS: We gathered for analysis 816 patients with AL amyloidosis from seven referral centers in t
PMID 23091105

Japanese Journal

プレB細胞レセプターの新たな役割--効率のよいBCR形成術 (特集1 B細胞の分化とその決定要因)

臨床免疫・アレルギー科 46(6), 555-559, 2006-12
NAID 40015251795

EBF and E47 collaborate to induce expression of the endogenous immunoglobulin orate to induce expression of the endogenous immunolobulin surrogate light chain genes.