sulfonylurea

出典: meddic

スルホニル尿素スルホニルウレアスルホニル尿素系薬剤スルホニル尿素薬スルホニル尿素剤、((俗))SU薬

  • ATP感受性K+チャネル阻害によりインスリンを分泌させる抗糖尿病薬

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「antidiabetic consisting of any of several drugs that reduce the level of glucose in the blood; used to treat diabetes mellitus」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/10/14 23:13:52」(JST)

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英文文献

  • Effects of chlorimuron ethyl on terrestrial and wetland plants: Levels of, and time to recovery following sublethal exposure.
  • Carpenter D, Boutin C, Allison JE.SourceEnvironment Canada, Science & Technology Branch, National Wildlife Research Centre, 1125 Colonel By Drive, Carleton University, Ottawa, Ontario, Canada K1A 0H3.
  • Environmental pollution (Barking, Essex : 1987).Environ Pollut.2013 Jan;172:275-82. doi: 10.1016/j.envpol.2012.09.007. Epub 2012 Nov 6.
  • Current pesticide registration guidelines call for short-term testing of plants; long-term effects on vegetative parts and reproduction remain untested. The aims of our study were to determine level of recovery and recovery times for plants exposed to the sulfonylurea herbicide chlorimuron ethyl usi
  • PMID 23137550
  • Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
  • Lee YT, Cui CJ, Chow EW, Pue N, Lonhienne T, Wang JG, Fraser JA, Guddat LW.AbstractThe sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway. It has previously been shown that if the gene for AHAS is deleted in Candida albicans attenuation of virulence is achieved, suggesting AHAS as an antifungal drug target. Herein, we have cloned, expressed and purified C. albicans AHAS and shown that several sulfonylureas are inhibitors of this enzyme and possess antifungal activity. The most potent of these compounds is ethyl 2-(N-((4-iodo-6-methoxypyrimidin-2-yl)carbamoyl) sulfamoyl)benzoate (10c), which has a Ki value of 3.8 nM for C. albicans AHAS and an MIC90 of 0.7 μg/mL for this fungus in cell-based assays. For the sulfonylureas tested there was a strong correlation between inhibitory activity towards C. albicans AHAS and fungicidal activity, supporting the hypothesis that AHAS is the target for their inhibitory activity within the cell.
  • Journal of medicinal chemistry.J Med Chem.2012 Dec 13. [Epub ahead of print]
  • The sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway. It has previously been shown that if the gene for AHAS is deleted in Candida albicans attenuation of virulence is achieved, s
  • PMID 23237384
  • Genetic Polymorphisms and Drug Interactions Leading to Clopidogrel Resistance: Why the Asian Population Requires Special Attention.
  • Hasan MS, Basri HB, Hin LP, Stanslas J.Source1Neurology Unit, Department of Medicine and Institute of Gerontology, Faculty of Medicine and Health Sciences, University Putra Malaysia , Serdang, Selangor Darul Ehsan , Malaysia.
  • The International journal of neuroscience.Int J Neurosci.2012 Dec 6. [Epub ahead of print]
  • ABSTRACT Ischemic heart disease and stroke are the two leading causes of death worldwide. Antiplatelet therapy plays the most significant role in the management of these cardiovascular and cerebrovascular occlusive events to prevent recurrent ischemic attack. Clopidogrel, an antiplatelet drug, is
  • PMID 23110469

和文文献

  • Synthesis and evaluation of 18F-labeled mitiglinide derivatives as positron emission tomography tracers for β-cell imaging.
  • Kimura Hiroyuki,Matsuda Hirokazu,Fujimoto Hiroyuki,Arimitsu Kenji,Toyoda Kentaro,Mukai Eri,Nakamura Hiroshi,Ogawa Yu,Takagi Mikako,Ono Masahiro,Inagaki Nobuya,Saji Hideo
  • Bioorganic & medicinal chemistry 22(13), 3270-3278, 2014-07-01
  • … FMITs) were synthesized and their binding affinity for the sulfonylurea receptor 1 (SUR1) of pancreatic islets were evaluated by inhibition studies. …
  • NAID 120005456028
  • 山形県の水田における近年の除草剤抵抗性雑草の現状
  • Diurnal patterns of plasma glucose in patients with type 2 diabetes receiving sulfonylurea and effectiveness of once daily lispro mix 50/50 injections
  • Mashitani Tsuyoshi,Tsujii Satoru,Hayashino Yasuaki [他]
  • Diabetology international 5(1), 30-35, 2014
  • NAID 40020028026
  • 血糖変動指標としての1,5-AG測定の有用性と治療効果判定への応用
  • 徳山 芳治,柳澤 葉子
  • 糖尿病 57(4), 227-234, 2014
  • 1,5-anhydroglucitol(AG)の血糖変動指標としての有用性を検証するため,連続血糖測定システム(CGM)で得られた血糖変動と1,5-AGとの相関,治療法によるHbA1cと1,5-AGの分布の相違,DPP-4阻害薬投与前後でHbA1cと1,5-AGの変化を調べた.1,5-AGはCGMで得られた血糖値の標準偏差およびMAGEと負の相関が認められた.治療法による検討では,HbA1c値によ …
  • NAID 130004511396

関連リンク

00:10 Sulfonylurea is always a great word to know. So is ninnyhammer. Does it mean: So is gobo. Does it mean: So is flibbertigibbet. Does it mean: a printed punctuation mark (‽), available only in some typefaces, designed to ...
Sulfonylurea derivatives are a class of antidiabetic drugs that are used in the management of diabetes mellitus type 2 ("adult-onset"). They act by increasing insulin release from the beta cells in the pancreas. Drugs in this class First ...
sul·fo·nyl·urea noun \ ˌ səl-fə-ˌ nil-ˈ y u r-ē-ə\ Definition of SULFONYLUREA: any of several hypoglycemic compounds related to the sulfonamides and used in the oral treatment of diabetes Origin of SULFONYLUREA New Latin, from ...

関連画像

Bedtime SulfonylureaSulfonylurea group highlighted in ( red )Secretion sulfonylureas Risk of Death Seen with Sulfonylurea UseAbout 'Sulfonylurea'Glyphosate + SulfonylUrea Herbicides WSGimage 32 sulfonylurea drugs were Sulfonylurea Wallpaper


★リンクテーブル★
リンク元スルホニル尿酸系薬」「SU薬」「スルホニル尿素薬」「スルホニル尿素」「スルホニルウレア
拡張検索sulfonylurea hypoglycemic agent」「hypoglycemic of sulfonylurea derivative」「sulfonylurea compound」「sulfonylurea receptor

スルホニル尿酸系薬」

  [★]

スルフォニル尿酸系薬SU剤スルホニル尿素系血糖降下薬
糖尿病治療薬薬理学

分類

スルフォニル尿酸系薬 sulfonylurea

  • -作用弱
  • -作用中
  • -作用強
  • -新薬

スルホンアミド系薬

作用機序

  • GOO.1634
  • ATP感受性KチャネルのSUR1サブユニットに結合し、チャネルを阻害する。膜が脱分極し、電位依存性Ca2+チャネルが開口する。

薬理作用

動態

適応

  • 以下の全てを満たす場合
  • 1. NIDDM
  • 2. 高度の肥満がない
  • 3. 食事療法、運動療法で満足な血糖コントロールが得られない
  • 4. 膵インスリン分解能をある程度保持 (尿中Cペプチド>20μg/day)
  • 5. 低血糖を理解し対応できる
  • 6. 妊婦ではない

注意

禁忌

  • 1. IDDM
  • 2. 重篤な感染症を繰り返す場合
  • 3. 大きな外科手術を受ける場合
  • 4. 高度の肝・腎障害がある場合
  • 5. 妊婦
  • 6. アレルギーなど副作用の発現を満たすもの

SU薬」

  [★]

sulfonylurea
スルホニル尿素スルホニルウレアスルホニル尿素剤スルホニル尿素薬スルホニル尿素系薬剤


スルホニル尿素薬」

  [★]

sulfonylurea SU
スルホニル尿素SU薬スルホニルウレアスルホニル尿素剤スルホニル尿素系薬剤


スルホニル尿素」

  [★]

sulfonylurea
SU薬スルホニルウレアスルホニル尿素剤スルホニル尿素薬スルホニル尿素系薬剤


スルホニルウレア」

  [★]

sulfonylurea
スルホニル尿素SU薬スルホニル尿素剤スルホニル尿素薬スルホニル尿素系薬剤


sulfonylurea hypoglycemic agent」

  [★] スルホニル尿素系抗糖尿病薬


hypoglycemic of sulfonylurea derivative」

  [★] スルホニル尿素系血糖降下薬

sulfonylurea compound」

  [★]

sulfonylurea receptor」

  [★]

SUR
SUR




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