substantia nigra

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/10 21:39:00」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/01/04 20:36:45」(JST)

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  • Changes in SK channel expression in the basal ganglia after partial nigrostriatal dopamine lesions in rats: Functional consequences.
  • Mourre C1, Manrique C2, Camon J1, Aidi-Knani S1, Deltheil T1, Turle-Lorenzo N2, Guiraudie-Capraz G3, Amalric M4.
  • Neuropharmacology.Neuropharmacology.2017 Feb;113(Pt A):519-532. doi: 10.1016/j.neuropharm.2016.11.003. Epub 2016 Nov 5.
  • Parkinson's disease (PD) is a progressive neurodegenerative disease originating from the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNC). The small-conductance calcium-activated potassium (SK) channels play an essential role in the regulation of midbrain DA neuron activity
  • PMID 27825825
  • Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease.
  • Elgueta D1, Aymerich MS2, Contreras F3, Montoya A3, Celorrio M4, Rojo-Bustamante E5, Riquelme E3, González H3, Vásquez M6, Franco R7, Pacheco R8.
  • Neuropharmacology.Neuropharmacology.2017 Feb;113(Pt A):110-123. doi: 10.1016/j.neuropharm.2016.09.028. Epub 2016 Sep 28.
  • Neuroinflammation involves the activation of glial cells, which is associated to the progression of neurodegeneration in Parkinson's disease. Recently, we and other researchers demonstrated that dopamine receptor D3 (D3R)-deficient mice are completely refractory to neuroinflammation and consequent n
  • PMID 27693549
  • Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study.
  • Zhang ZN1, Zhang JS1, Xiang J1, Yu ZH1, Zhang W1, Cai M1, Li XT1, Wu T1, Li WW1, Cai DF2.
  • Brain research.Brain Res.2017 Jan 15;1655:104-113. doi: 10.1016/j.brainres.2016.11.020. Epub 2016 Nov 19.
  • Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiven
  • PMID 27876560


  • Fetal stem cell transplantation : Past, present, and future
  • Ishii Tetsuya
  • World Journal of Stem Cells 6(4), 404-420, 2014-09-26
  • … Although the transplantation of the fetal midbrain substantia nigra and dopaminergic neurons in patients suffering from Parkinson's disease is particularly noteworthy, the history of other types of grafts, such as those of the fetal liver, thymus, and pancreas, should be addressed as there are many lessons to be learnt for future stem cell transplantation. …
  • NAID 120005476090
  • パーキンソン病の早期診断における検査法
  • 飯嶋 睦
  • 東京女子医科大学雑誌 84(E1), E35-E41, 2014-01-31
  • パーキンソン病(Parkinson's disease:PD)は、特徴的な4運動徴候、すなわち振戦、筋強剛、無動、姿勢反射障害に加え、便秘、うつ、睡眠障害、嗅覚障害、認知機能障害など様々な非運動症状を呈する、Lewy小体病理変化を呈する全身疾患と捉えられている。運動症状が出現した時点で、60%以上の黒質の神経細胞は脱落しており、発症早期の治療介入が機能予後に影響することから、PDでは早期の確定診断 …
  • NAID 110009752552
  • Protective Effect of Chinonin in MPTP-Induced C57BL/6 Mouse Model of Parkinson's Disease
  • Feng Guoshuai,Zhang Zhijian,Bao Qingqing,Zhang Zaijun,Zhou Libing,Jiang Jie,Li Sha
  • Biological and Pharmaceutical Bulletin 37(8), 1301-1307, 2014
  • … Consistently, chinonin reduced loss of dopaminergic neurons in the substantia nigra and prevented depletion of dopamine and its metabolites 3-methoxy-4-hydroxy-phenylacetic acid and homovanillic acid in the striatum of mice. …
  • NAID 130004147357


The substantia nigra lies in the midbrain immediately dorsal to the cerebral peduncles. This nucleus is an important motor center that will be discussed at greater length later in the course. Right now you need to know that some of ...
The focus is on how the interplay between glutamate and dopamine, particularly at the level of medium spiny neurons in the striatum and at the level of output from the substantia nigra, contributes to the fine-tuning of analogue ...


 Substantia Nigra – Neuroscience NewsFile:Substantia Nigra.jpg - Wikipedia, the Substantia nigra - Patienthåndbogen på Substantia nigra location substantia nigra helps control movementSubstantia nigra - 黒質 - EnglishClass

拡張検索GABA neurons in the reticular part of substantia nigra



substantia nigra (KH)
黒核 intercalatum, nucleus nigra




  • ドーパミン作動性ニューロンの脱落により発病

Henry Gray (1825-1861). Anatomy of the Human Body. 1918.
Henry Gray (1825-1861). Anatomy of the Human Body. 1918.




nigranigralsubstantia nigra



  • 黒質の
nigraSNsubstantia nigra

GABA neurons in the reticular part of substantia nigra」

  [★] 黒質網様帯GABAニューロン




nigralSNsubstantia nigra



  • n.