stromal

出典: meddic

  • adj.
  • 間質性の、間質の、(眼科)角膜実質、支質の、ストローマの


corneal stromainterstitialinterstitial tissueinterstitiumstromastromata

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/23 20:54:11」(JST)

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英文文献

  • Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis.
  • Saldanha SN, Tollefsbol TO.Author information Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Biological Sciences, Alabama State University, Montgomery, Alabama.AbstractCellular pathways are numerous and are highly integrated in function in the control of cellular systems. They collectively regulate cell division, proliferation, survival and apoptosis of cells and mutagenesis of key genes that control these pathways can initiate neoplastic transformations. Understanding these pathways is crucial to future therapeutic and preventive strategies of the disease. Ovarian cancers are of three major types; epithelial, germ-cell, and stromal. However, ovarian cancers of epithelial origin, arising from the mesothelium, are the predominant form. Of the subtypes of ovarian cancer, the high-grade serous tumors are fatal, with low survival rate due to late detection and poor response to treatments. Close examination of preserved ovarian tissues and in vitro studies have provided insights into the mechanistic changes occurring in cells mediated by a few key genes. This review will focus on pathways and key genes of the pathways that are mutated or have aberrant functions in the pathology of ovarian cancer. Non-genetic mechanisms that are gaining prominence in the pathology of ovarian cancer, miRNAs and epigenetics, will also be discussed in the review. J. Cell. Physiol. 229: 393-406, 2014. © 2013 Wiley Periodicals, Inc.
  • Journal of cellular physiology.J Cell Physiol.2014 Apr;229(4):393-406. doi: 10.1002/jcp.24466.
  • Cellular pathways are numerous and are highly integrated in function in the control of cellular systems. They collectively regulate cell division, proliferation, survival and apoptosis of cells and mutagenesis of key genes that control these pathways can initiate neoplastic transformations. Understa
  • PMID 24105793
  • Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment.
  • Bohonowych J, Hance M, Nolan K, Defee M, Parsons Ch, Isaacs J.Author information Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina.AbstractBACKGROUND: The tumor microenvironment (TME) plays an essential role in supporting and promoting tumor growth and progression. An inflammatory stroma is a widespread hallmark of the prostate TME, and prostate tumors are known to co-evolve with their reactive stroma. Cancer-associated fibroblasts (CAFs) within the reactive stroma play a salient role in secreting cytokines that contribute to this inflammatory TME. Although a number of inflammatory mediators have been identified, a clear understanding of key factors initiating the formation of reactive stroma is lacking.
  • The Prostate.Prostate.2014 Apr;74(4):395-407. doi: 10.1002/pros.22761. Epub 2013 Dec 16.
  • BACKGROUND: The tumor microenvironment (TME) plays an essential role in supporting and promoting tumor growth and progression. An inflammatory stroma is a widespread hallmark of the prostate TME, and prostate tumors are known to co-evolve with their reactive stroma. Cancer-associated fibroblasts (CA
  • PMID 24338924
  • Loss of stromal JUNB does not affect tumor growth and angiogenesis.
  • Braun J, Strittmatter K, Nübel T, Komljenovic D, Sator-Schmitt M, Bäuerle T, Angel P, Schorpp-Kistner M.Author information Division of Signal Transduction and Growth Control DKFZ DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany.AbstractThe transcription factor AP-1 subunit JUNB has been shown to play a pivotal role in angiogenesis. It positively controls angiogenesis by regulating Vegfa as well as the transcriptional regulator Cbfb and its target Mmp13. In line with these findings, it has been demonstrated that tumor cell-derived JUNB promotes tumor growth and angiogenesis. In contrast to JUNB's function in tumor cells, the role of host-derived stromal JUNB has not been elucidated so far. Here, we show that ablation of Junb in stromal cells including endothelial cells (ECs), vascular smooth muscle cells (SMCs) and fibroblasts does not affect tumor growth in two different syngeneic mouse models, the B16-F1 melanoma and the Lewis lung carcinoma model. In-depth analyses of the tumors revealed that tumor angiogenesis remains unaffected as assessed by measurements of the microvascular density and relative blood volume in the tumor. Furthermore, we could show that the maturation status of the tumor vasculature, analyzed by the SMC marker expression, α-smooth muscle actin and Desmin, as well as the attachment of pericytes to the endothelium, is not changed upon ablation of Junb. Taken together, these results indicate that the pro-angiogenic functions of stromal JUNB are well compensated with regard to tumor angiogenesis and tumor growth.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 15;134(6):1511-6. doi: 10.1002/ijc.28477. Epub 2013 Oct 9.
  • The transcription factor AP-1 subunit JUNB has been shown to play a pivotal role in angiogenesis. It positively controls angiogenesis by regulating Vegfa as well as the transcriptional regulator Cbfb and its target Mmp13. In line with these findings, it has been demonstrated that tumor cell-derived
  • PMID 24027048

和文文献

  • 症例 閉経後に著明な男性化徴候を示したalpha-fetoprotein産生卵巣Sertroli-stromal cell tumorの1例
  • 山下 詩乃,武内 享介,吉田 愛 [他]
  • 産婦人科の実際 63(4), 617-619, 2014-04
  • NAID 40020057561
  • 臨床経験 術後31年目に発見された低悪性度子宮内膜間質肉腫の孤立性肺転移
  • 滝沢 昌也,田中 伸佳,常塚 宣男 [他]
  • 胸部外科 = The Japanese journal of thoracic surgery 67(4), 333-336, 2014-04
  • NAID 40020027434
  • Effects of Polyethylene Glycol Administration and Bone Marrow Stromal Cell Transplantation Therapy in Spinal Cord Injury Mice
  • ODA Yasutaka,TANI Kenji,ISOZAKI Atsunobu [他]
  • The journal of veterinary medical science 76(3), 415-421, 2014-03
  • NAID 40020035122

関連リンク

Stromal definition, Cell Biology. the supporting framework or matrix of a cell. See more. Thesaurus Translator Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In follow Dictionary.com ...
In cell biology, stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, and the ovary. They are cells that support the function of the parenchymal cells of that ...

関連画像

Pap Smear Endometrial Stromal Cells | Foto Stromal. Causes, symptoms, treatment Stromal - cell expression ofDeep endometrial stromal cellsstromal cells assembly of stromal Stromal scar typically seen in patients


★リンクテーブル★
リンク元interstitial」「間質性」「支質」「ストローマ」「stromata
拡張検索Sertoli-stromal cell tumor」「stromal corneal dystrophy
関連記事stroma

interstitial」

  [★]

  • adj.
  • 間質性の、間質内の、侵入型の、組織内の、介在の、介在性の、中間部の、間質の
intercalaryintermediateinternuncialinterstitial tissueinterstitiuminterveneinterveninginterzonalinvasivestromastromalstromata

WordNet   license wordnet

「of or relating to interstices」


間質性」

  [★]

interstitialstromal
介在介在性間質間質内支質侵入型ストローマストロマ組織内中間部角膜実質


支質」

  [★]

stromastromatastromal
間質間質性基質ストローマストロマ子座角膜実質


ストローマ」

  [★]

stromastromatastromal
間質間質性基質支質ストロマ子座角膜実質


stromata」

  [★]

間質支質ストローマ

interstitialinterstitial tissueinterstitiumstromastromal


Sertoli-stromal cell tumor」

  [★] セルトリ間質細胞腫瘍


stromal corneal dystrophy」

  [★] 角膜実質ジストロフィ


stroma」

  [★]

  • n.


WordNet   license wordnet

「a mass of fungal tissue that has spore-bearing structures embedded in it or on it」

WordNet   license wordnet

「the dense colorless framework of a chloroplast」

WordNet   license wordnet

「the supporting tissue of an organ (as opposed to parenchyma)」


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