- 関
- spider venom
WordNet
- a skillet made of cast iron
- predatory arachnid with eight legs, two poison fangs, two feelers, and usually two silk-spinning organs at the back end of the body; they spin silk to make cocoons for eggs or traps for prey
- a computer program that prowls the internet looking for publicly accessible resources that can be added to a database; the database can then be searched with a search engine (同)wanderer
- a poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species
PrepTutorEJDIC
- クモ / 《米》フライパン
- (特にバクテリアの)毒素
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/06 05:47:03」(JST)
[Wiki en表示]
| Spider toxin |
|
Solution structure of omega-agatoxin-Aa4a from Agelenopsis aperta.[1]
|
| Identifiers |
| Symbol |
Toxin_9 |
| Pfam |
PF02819 |
| Pfam clan |
CL0083 |
| InterPro |
IPR004169 |
| SCOP |
1oav |
| SUPERFAMILY |
1oav |
| OPM superfamily |
120 |
| OPM protein |
1agg |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
| Delta Atracotoxin |
| Identifiers |
| Symbol |
Atracotoxin |
| Pfam |
PF05353 |
| InterPro |
IPR008017 |
| SCOP |
1qdp |
| SUPERFAMILY |
1qdp |
| OPM protein |
1vtx |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
| Spider toxin CSTX family |
| Identifiers |
| Symbol |
Toxin_35 |
| Pfam |
PF10530 |
| InterPro |
IPR011142 |
| PROSITE |
PDOC60029 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
| Spider potassium channel inhibitory toxin |
| Identifiers |
| Symbol |
Toxin_12 |
| Pfam |
PF07740 |
| Pfam clan |
CL0083 |
| InterPro |
IPR011696 |
| SCOP |
1d1h |
| SUPERFAMILY |
1d1h |
| OPM protein |
1qk6 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
Spider toxins are a family of proteins produced by spiders which function as neurotoxins. The mechanism of many spider toxins is through blockage of calcium channels.
A remotely related group of atracotoxins operate by opening sodium channels. Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels.[2] The structure of atracotoxin comprises a core beta region containing a triple-stranded a thumb-like extension protruding from the beta region and a C-terminal helix. The beta region contains a cystine knot motif, a feature seen in other neurotoxic polypeptides[2] and other spider toxins, of the CSTX family.
Spider potassium channel inhibitory toxins is another group of spider toxins. A representative of this group is hanatoxin, a 35 amino acid peptide toxin which was isolated from Chilean rose tarantula (Grammostola rosea, syn. G. spatulata) venom. It inhibits the drk1 voltage-gated potassium channel by altering the energetics of gating.[3] See also Huwentoxin-1 InterPro: IPR013140.
See also
References
- ^ PDB: 1IVA; Reily MD, Holub KE, Gray WR, Norris TM, Adams ME (December 1994). "Structure-activity relationships for P-type calcium channel-selective omega-agatoxins". Nat. Struct. Biol. 1 (12): 853–6. doi:10.1038/nsb1294-853. PMID 7773772.
- ^ a b Mackay JP, King GF, Fletcher JI, Chapman BE, Howden ME (1997). "The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel". Structure 5 (11): 1525–1535. doi:10.1016/S0969-2126(97)00301-8. PMID 9384567.
- ^ Shimada I, Sato K, Takahashi H, Kim JI, Min HJ, Swartz KJ (2000). "Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins". J. Mol. Biol. 297 (3): 771–780. doi:10.1006/jmbi.2000.3609. PMID 10731427.
Further reading
- Kim JI, Konishi S, Iwai H, Kohno T, Gouda H, Shimada I, Sato K, Arata Y (July 1995). "Three-dimensional solution structure of the calcium channel antagonist omega-agatoxin IVA: consensus molecular folding of calcium channel blockers". J. Mol. Biol. 250 (5): 659–71. doi:10.1006/jmbi.1995.0406. PMID 7623383.
This article incorporates text from the public domain Pfam and InterPro IPR008017
UpToDate Contents
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English Journal
- Lachesana tarabaevi, an expert in membrane-active toxins.
- Kuzmenkov AI1, Sachkova MY1, Kovalchuk SI1, Grishin EV1, Vassilevski AA2.
- The Biochemical journal.Biochem J.2016 Jun 10. pii: BCJ20160436. [Epub ahead of print]
- We show that venom of the ant spider Lachesana tarabaevi is unique in terms of molecular composition and toxicity. Whereas venom of most studied spiders is rich in disulfide-containing neurotoxic peptides, L. tarabaevi relies on production of linear (no S-S bridges) cytolytic polypeptides. We perfo
- PMID 27287558
- Protective antibodies against a sphingomyelinase D from Loxosceles intermedia spider venom elicited in mice with different genetic background.
- Oliveira CF1, Vilela A1, Coura LA1, Rodrigues FT1, Nagem RA1, Chávez-Olortegui C1, Maioli TU2, Felicori LF1.
- Vaccine.Vaccine.2016 Jun 10. pii: S0264-410X(16)30365-6. doi: 10.1016/j.vaccine.2016.05.039. [Epub ahead of print]
- In the present investigation we used a recombinant LiD1 toxin, named rLiD1his, from Loxosceles intermedia brown spider to elicit specific antibodies in mice carrying different Human Leukocyte Antigens class II (HLAII) {DRB1.0401 (DR4), DQB1.0601 (DQ6) and DQB1.0302 (DQ8)} as well as in BALB/C and C5
- PMID 27265457
- Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.
- Joeres N1, Augustinowski K1, Neuhof A1, Assmann M1, Gründer S1.
- Scientific reports.Sci Rep.2016 Jun 9;6:27647. doi: 10.1038/srep27647.
- Acid Sensing Ion Channels (ASICs) detect extracellular proton signals and are involved in synaptic transmission and pain sensation. ASIC subunits assemble into homo- and heteromeric channels composed of three subunits. Single molecule imaging revealed that heteromers composed of ASIC1a and ASIC2a, w
- PMID 27277303
Japanese Journal
- Modular toxins from spider venom - peptides with unique structure
- Peptide science : proceedings of the ... Japanese Peptide Symposium 2010, 122, 2011-03-01
- NAID 10028237520
- P-76 MALDI-SpiralTOF-TOF質量分析計を用いた天然有機化合物の高エネルギーCID MS/MS測定(ポスター発表の部)
- Synthesis of Spider Toxin NPTX-594 Analogs with the Alkyne Group for Post Fluorescent Labeling Based on Click Chemistry
- Peptide science : proceedings of the ... Japanese Peptide Symposium 2008, 429-432, 2009-03-01
- NAID 10027166640
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- 英
- spider toxin、spider venom
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- 関
- spider toxin
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