女郎グモ毒、Joroグモ毒

WordNet

a skillet made of cast iron
predatory arachnid with eight legs, two poison fangs, two feelers, and usually two silk-spinning organs at the back end of the body; they spin silk to make cocoons for eggs or traps for prey
a computer program that prowls the internet looking for publicly accessible resources that can be added to a database; the database can then be searched with a search engine (同)wanderer
a poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species

PrepTutorEJDIC

クモ / 《米》フライパン
(特にバクテリアの)毒素

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/12 11:54:21」(JST)

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Joro spider toxin (joro toxin, JSTX) - a toxin which was originally extracted from the spider Nephila clavata venom. The compound has demonstrated the ability to selectively block postsynaptic glutamate potentials, AMPA glutamate receptors, and to antagonise the effect of NMDA receptors in the CNS of vertebrates. However, it does not affect aspartate-induced neural depolarization, resting membrane potential, nerve terminal spontaneous signalling, or inhibitory postsynaptic potentials.

Literature

Kawai, Nobufumi; Niwa, Akiko; Abe, Takashi (1982). "Spider venom contains specific receptor blocker of glutaminergic synapses". Brain Research 247 (1): 169–71. doi:10.1016/0006-8993(82)91044-7. PMID 6127145.
Shudo, Koichi; Endo, Yasuyuki; Hashimoto, Yuichi; Aramaki, Yoshio; Nakajima, Terumi; Kawai, Nobufumi (1987). "Newly synthesized analogues of the spider toxin block the crustacean glutamate receptor". Neuroscience Research 5 (1): 82–5. doi:10.1016/0168-0102(87)90026-5. PMID 2829068.
Jackson, H.; Usherwood, P.N.R. (1988). "Spider toxins as tools for dissecting elements of excitatory amino acid transmission". Trends in Neurosciences 11 (6): 278–83. doi:10.1016/0166-2236(88)90112-9. PMID 2465627.
Saito, Mitsuyoshi; Sahara, Yoshinori; Miwa, Akiko; Shimazaki, Kuniko; Nakajima, Terumi; Kawai, Nobufumi (1989). "Effects of a spider toxin (JSTX) on hippocampal CA1 neurons in vitro". Brain Research 481 (1): 16–24. doi:10.1016/0006-8993(89)90480-0. PMID 2565131.
Sahara, Yoshinori; Robinson, Hugh P.C.; Miwa, Akiko; Kawai, Nobufumi (1991). "A voltage-clamp study of the effects of Joro spider toxin and zinc on excitatory synaptic transmission in CA1 pyramidal cells of the guinea pig hippocampal slice". Neuroscience Research 10 (3): 200–10. doi:10.1016/0168-0102(91)90057-6. PMID 1677747.
Kawai, Nobufumi (1991). "Spider toxin and pertussis toxin differentiate post- and presynaptic glutamate receptors". Neuroscience Research 12 (1): 3–12. doi:10.1016/0168-0102(91)90095-G. PMID 1660989.
Mueller, Alan L.; Albensi, Benedict C.; Ganong, Alan H.; Reynolds, Linda S.; Jackson, Hunter (1991). "Arylamine spider toxins antagonize NMDA receptor-mediated synaptic transmission in rat hippocampal slices". Synapse 9 (4): 244–50. doi:10.1002/syn.890090403. PMID 1662833.

UpToDate Contents

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1. ゴケグモによる咬刺傷のマネージメント management of widow spider bites
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English Journal

Structure-activity relationship study of spider polyamine toxins as inhibitors of ionotropic glutamate receptors.

Xiong XF1, Poulsen MH, Hussein RA, Nørager NG, Strømgaard K.
ChemMedChem.ChemMedChem.2014 Dec;9(12):2661-70. doi: 10.1002/cmdc.201402278. Epub 2014 Sep 29.
The spider polyamine toxins Joro spider toxin-3 (JSTX-3) and Nephila polyamine toxins-1 and -8 (NPTX-1 and NPTX-8) are isolated from the venom of the orb-weaver spider Nephila clavata (Joro spider). They share a high degree of structural resemblance, their aromatic head groups being the only differe
PMID 25267300

Modulation of neurite outgrowth by activation of calcium-permeable kainate receptors expressed by rat nociceptive-like dorsal root ganglion neurons.

Joseph DJ1, Williams DJ, MacDermott AB.
Developmental neurobiology.Dev Neurobiol.2011 Oct;71(10):818-35. doi: 10.1002/dneu.20906.
Neurite outgrowth is a fundamental step in establishing proper neuronal connections in the developing central nervous system. Dynamic control of outgrowth has been attributed to changes in growth cone Ca2+ levels in response to extracellular cues. Here we have investigated a possible role for Ca2+ p
PMID 21557511

Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata.

Barslund AF1, Poulsen MH, Bach TB, Lucas S, Kristensen AS, Strømgaard K.
Journal of natural products.J Nat Prod.2011 Mar 25;74(3):483-6. doi: 10.1021/np100746w. Epub 2010 Dec 28.
Polyamine toxins from orb weaver spiders are attractive pharmacological tools particularly for studies of ionotropic glutamate (iGlu) receptors in the brain. These polyamine toxins are biosynthesized in a combinatorial manner, providing a plethora of related, but structurally complex toxins to be ex
PMID 21188966

Japanese Journal

クモ毒NPTX-594の蛍光標識類縁体の合成と生物活性に関する研究

近畿大学理工学部研究報告 42, 23-28, 2006-09-30
NAID 110006427236

ブラジル産ジョロウグモから単離された新規アシルポリアミンの構造決定(理学科)

近畿大学理工学部研究報告 41, 23-29, 2005-09-30
NAID 110004615585

Structural Study of Novel Acylpolyaminetoxins from the Venom of Nephila clavipes, a Brazilian Joro Spider

Peptide science : proceedings of the ... Japanese Peptide Symposium 2004, 669-672, 2005-03-01
NAID 10014460826

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★リンクテーブル★

リンク元	「Joroグモ毒」「女郎グモ毒」
関連記事	「spider toxin」

「Joroグモ毒」

Joro toxin
Names
	IUPAC name N1-{5-[(N-{4-[(3-aminopropyl)amino]butyl}-β-alanyl)amino]pentyl}-N2-[(2,4-dihydroxyphenyl)acetyl]-L-aspartamide
	Other names Joro Spider toxin
Identifiers
CAS Registry Number	112163-33-4
ChEBI	CHEBI:245409
ChEMBL	ChEMBL119582
ChemSpider	106778
	InChI InChI=1S/C27H47N7O6/c28-10-6-13-30-11-4-5-12-31-16-9-25(38)32-14-2-1-3-15-33-27(40)22(19-24(29)37)34-26(39)17-20-7-8-21(35)18-23(20)36/h7-8,18,22,30-31,35-36H,1-6,9-17,19,28H2,(H2,29,37)(H,32,38)(H,33,40)(H,34,39)/t22-/m0/s1 ; Key: SJLRBGDPTALRDM-QFIPXVFZSA-N ;
Jmol-3D images	Image
KEGG	C13931
PubChem	119582
	SMILES O=C(NCCCCCNC(=O)[C@@H](NC(=O)Cc1ccc(O)cc1O)CC(=O)N)CCNCCCCNCCCN ;
Properties
Chemical formula	C27H47N7O6
Molar mass	565.72 g·mol−1
Appearance	White-grey powder
Density	1.196 g/cm3
Boiling point	979.883 °C (1,795.789 °F; 1,253.033 K)
Acidity (pKa)	9.53
Basicity (pKb)	10.573
Hazards
Flash point	546.414 °C (1,015.545 °F; 819.564 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references