WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
a salt or ester of hydriodic acid

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Hybrid Light Imaging Using Cerenkov Luminescence and Liquid Scintillation for Preclinical Optical Imaging In Vivo.

Shimamoto M1, Gotoh K2, Hasegawa K3, Kojima A4.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.Mol Imaging Biol.2016 Aug;18(4):500-9. doi: 10.1007/s11307-016-0928-y.
PURPOSE: Cerenkov luminescence imaging (CLI) has recently emerged as a molecular imaging modality for radionuclides emitting β-particles. The aim of this study was to develop a hybrid light imaging (HLI) technique using a liquid scintillator to assist CLI by increasing the optical signal intensity
PMID 26819217

Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery.

Müller AM1, Schmohl KA1, Knoop K1, Schug C1, Urnauer S1, Hagenhoff A2, Clevert DA3, Ingrisch M3, Niess H4, Carlsen J5, Zach C5, Wagner E6, Bartenstein P5, Nelson PJ2, Spitzweg C1.
Oncotarget.Oncotarget.2016 Jul 21. doi: 10.18632/oncotarget.10758. [Epub ahead of print]
Adoptively transferred mesenchymal stem cells (MSCs) home to solid tumors. Biologic features within the tumor environment can be used to selectively activate transgenes in engineered MSCs after tumor invasion. One of the characteristic features of solid tumors is hypoxia. We evaluated a hypoxia-base
PMID 27458162

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy.

Renier C1, Do J1, Reyna-Neyra A2, Foster D1, De A3,4, Vogel H5, Jeffrey SS1, Tse V6, Carrasco N2, Wapnir I1.
Oncotarget.Oncotarget.2016 Jun 23. doi: 10.18632/oncotarget.10238. [Epub ahead of print]
Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-). We show impressive enhancement of tumor response by combining131I- with gemcitabine (GEM), a cytotoxic radiosensitizer. Nude mic
PMID 27363025

Combined Cerenkov luminescence and nuclear imaging of radioiodine in the thyroid gland and thyroid cancer cells expressing sodium iodide symporter: Initial feasibility study

Jeong Shin Young,Hwang Mi-Hye,Kim Jung Eun,Kang Sungmin,Park Jeong Chan,Yoo Jeongsoo,Ha Jeoung-Hee,Lee Sang-Woo,Ahn Byeong-Cheol,Lee Jaetae
Endocrine Journal 58(7), 575-583, 2011
… Radioiodine (RI) such as 131I or 124I, can generate luminescent emission and be detected with an optical imaging (OI) device. … To evaluate the possibility of a novel Cerenkov luminescence imaging (CLI) for application in thyroid research, we performed feasibility studies of CLI by RI in the thyroid gland and human anaplastic thyroid carcinoma cells expressing sodium iodide symporter gene (ARO-NIS). …
NAID 130004443721

LIN Jen-Der,CHAO Tzu-Chieh
Endocrine Journal 53(4), 441-448, 2006
… Although radioactive iodide (131I) has been used as the standard treatment for follicular thyroid carcinoma with distant metastases, the effectiveness of 131I treatment for follicular thyroid carcinoma depends on the differentiation of cancer cells. … The possibility of 131I for thyroid remnant ablation replacing a secondary operation for follicular thyroid carcinoma has been debated. …
NAID 130004443243

Obara Kijuro,Ono Shigeru,Nishizuka Fusao,Hatano Masao
The Tohoku Journal of Experimental Medicine 89(4), 375-382, 1966
… The distribution rate of sodium iodide (Na131I) and toxohormone labeled with Na131I in rats under various experimental conditions was described. … Compared with the distribution of Na131I in the liver and spleen of the normal rats, that of Na131I labeled toxohormone in the above organs was found to be characteristically decreased. …
NAID 130003497700