secondary lymphoid tissue chemokine

出典: meddic

二次リンパ組織ケモカイン SLC

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  • Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity.
  • Peske JD1, Thompson ED1, Gemta L1, Baylis RA1, Fu YX2, Engelhard VH1.
  • Nature communications.Nat Commun.2015 May 13;6:7114. doi: 10.1038/ncomms8114.
  • The presence of lymph node (LN)-like vasculature in tumours, characterized by expression of peripheral node addressin and chemokine CCL21, is correlated with T-cell infiltration and positive prognosis in breast cancer and melanoma patients. However, mechanisms controlling the development of LN-like
  • PMID 25968334
  • NFAT-1, Sp-1, Sp-3, and miR-21: New regulators of chemokine C receptor 7 expression in mature human dendritic cells.
  • Al Akoum C1, Akl I2, Rouas R2, Fayyad-Kazan M1, Falha L1, Renno T3, Burny A2, Lewalle P2, Fayyad-Kazan H2, Badran B4.
  • Human immunology.Hum Immunol.2015 May;76(5):307-17. doi: 10.1016/j.humimm.2015.03.010. Epub 2015 Mar 19.
  • The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cel
  • PMID 25797200
  • Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L.
  • Nakayama Y1, Brinkman CC, Bromberg JS.
  • Transplantation.Transplantation.2015 Apr 8. [Epub ahead of print]
  • BACKGROUND: Costimulatory blockade with anti-CD40L monoclonal antibody (mAb) plus donor-specific splenocyte transfusion (DST) induces alloantigen-specific tolerance. We previously showed that lymphotoxin signaling in the fibroblastic reticular cell (FRC) stromal subset was required for proper lymph
  • PMID 25856408


  • Children's Immunology, what can we learn from animal studies (3) : Impaired mucosal immunity in the gut by 2,3,7,8-tetraclorodibenzo-p-dioxin (TCDD) : A possible role for allergic sensitization
  • Journal of toxicological sciences 34(Special Issue II), SP349-SP361, 2009-07
  • … Instead, particular chemokine receptor expression on B1 cells, a major cell source for intestinal IgA antibody, was decreased in mice treated with TCDD. … In consistence with this observation, B1, but not B2 cells from TCDD treated mice showed impaired chemotaxis towards B lymphocyte chemokine (BLC)/CXCL13. …
  • NAID 110007337701
  • Fibrocyte: New participant in the pathogenesis of renal fibrosis
  • , , ,
  • Inflammation and Regeneration 28(1), 20-26, 2008
  • … Fibrocytes have been reported to rapidly enter sites of tissue injury and contribute to the pathogenesis of fibrotic conditions. … Fibrocytes express CCR7 and migrate in response to secondary lymphoid tissue chemokine (SLC/CCL21). …
  • NAID 130004482202
  • 腸管免疫におけるビタミンAの役割
  • 岩田 誠
  • 腸内細菌学雑誌 = Journal of intestinal microbiology 21(4), 297-304, 2007-10-01
  • 広い表面積で外界と接する腸管では,免疫細胞の配備が必須である.一般に,リンパ球の組織への配備は一定のルールに則って行われる.ナイーブT細胞は,リンパ節などの二次リンパ系器官には移入できるものの,非リンパ系組織には移入できない.二次リンパ系器官で抗原刺激を受けてエフェクター/メモリーT細胞となると,その二次リンパ系器官が所属する組織に選択的に移入(ホーミング)できるようになる.例えば,腸の二次リンパ …
  • NAID 10019966283




関連記事secondary」「tissue」「lymphoid」「lymphoid tissue





secondary lymphoid tissue chemokineSLC



secondary lymphoid tissue chemokine SLC



  • adj.
  • (地位・価値・重要性などが)第2の、2番目の、(~の)次の(to)。二次的な、従位の
Postmortem examination of patients with such obstructions without a history of clinical manifestations of myocardial ischemia often shows macroscopic scars secondary to MI in regions supplied by diseased coronary arteries, with or without collateral circulation.
in the past the commonest cause of death has been venous thrombosis followed by infection secondary to severe neutropenia and hemorrhage secondary to severe thrombocytopenia.(HIM.661)(重度の好中球減少に次ぐ感染と血小板減少に次ぐ出血に続発する静脈血栓症が昔の最も一般的な死因であった)
  • 副次的な(発生などが)派生的な

WordNet   license wordnet

「not of major importance; "played a secondary role in world events"」

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「the defensive football players who line up behind the linemen」

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「being of second rank or importance or value; not direct or immediate; "the stone will be hauled to a secondary crusher"; "a secondary source"; "a secondary issue"; "secondary streams"」

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「belonging to a lower class or rank」

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「depending on or incidental to what is original or primary; "a secondary infection"」

PrepTutorEJDIC   license prepejdic

「『第2の』,2番目の;(…の)次の《+『to』+『名』》 / 派生的な,二次的な,あまり重要でない / 中等学校[教育]の / 二次電流の」



  • n.

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「a soft thin (usually translucent) paper」
tissue paper

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「part of an organism consisting of an aggregate of cells having a similar structure and function」

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper」



  • adj.
lymphatic system

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「resembling lymph or lymphatic tissues」

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lymphoid tissue」



lymphatic tissue