CCL21

同

secondary lymphoid tissue chemokine SLC

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/04 23:37:10」(JST)

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Chemokine (C-C motif) ligand 21
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L4N
Identifiers
Symbols	CCL21 ; 6Ckine; CKb9; ECL; SCYA21; SLC; TCA4
External IDs	OMIM: 602737 HomoloGene: 2247 GeneCards: CCL21 Gene
Gene ontology Molecular function • chemokine activity • CCR7 chemokine receptor binding • chemokine receptor binding Cellular component • extracellular region • extracellular space Biological process • establishment of T cell polarity • immunological synapse formation • positive regulation of cell-matrix adhesion • dendritic cell chemotaxis • positive regulation of dendritic cell antigen processing and presentation • inflammatory response • immune response • cell-cell signaling • positive regulation of glycoprotein biosynthetic process • positive regulation of actin filament polymerization • positive regulation of pseudopodium assembly • T cell costimulation • ruffle organization • activation of Rho GTPase activity • positive regulation of cell adhesion mediated by integrin • response to prostaglandin E • mesangial cell-matrix adhesion • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of protein kinase activity • positive regulation of JNK cascade • positive regulation of receptor-mediated endocytosis • cell maturation • positive regulation of chemotaxis • release of sequestered calcium ion into cytosol • positive regulation of filopodium assembly • positive regulation of protein kinase B signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of neutrophil chemotaxis • dendritic cell dendrite assembly • negative regulation of leukocyte apoptotic process • positive regulation of cell motility • positive regulation of T cell migration • positive regulation of myeloid dendritic cell chemotaxis • negative regulation of dendritic cell dendrite assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6366	18829
Ensembl	ENSG00000137077	ENSMUSG00000094686
UniProt	O00585	P84444
RefSeq (mRNA)	NM_002989	NM_011124
RefSeq (protein)	NP_002980	NP_035254
Location (UCSC)	Chr 9: 34.71 – 34.71 Mb	Chr 4: 42.77 – 42.77 Mb
PubMed search	[1]	[2]

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

References

Further reading

• Nagira M, Imai T, Hieshima K et al. (1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13.". J. Biol. Chem. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955. 
• Hedrick JA, Zlotnik A (1997). "Identification and characterization of a novel beta chemokine containing six conserved cysteines.". J. Immunol. 159 (4): 1589–93. PMID 9257816. 
• Hromas R, Kim CH, Klemsz M et al. (1997). "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension.". J. Immunol. 159 (6): 2554–8. PMID 9300671. 
• Gunn MD, Tangemann K, Tam C et al. (1998). "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 258–63. doi:10.1073/pnas.95.1.258. PMC 18193. PMID 9419363. 
• Yoshida R, Nagira M, Kitaura M et al. (1998). "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7.". J. Biol. Chem. 273 (12): 7118–22. doi:10.1074/jbc.273.12.7118. PMID 9507024. 
• Campbell JJ, Bowman EP, Murphy K et al. (1998). "6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7.". J. Cell Biol. 141 (4): 1053–9. doi:10.1083/jcb.141.4.1053. PMC 2132769. PMID 9585422. 
• Jenh CH, Cox MA, Kaminski H et al. (1999). "Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors.". J. Immunol. 162 (7): 3765–9. PMID 10201891. 
• Gosling J, Dairaghi DJ, Wang Y et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668. 
• Annunziato F, Romagnani P, Cosmi L et al. (2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection.". J. Immunol. 165 (1): 238–46. doi:10.4049/jimmunol.165.1.238. PMID 10861057. 
• Hirose J, Kawashima H, Yoshie O et al. (2001). "Versican interacts with chemokines and modulates cellular responses.". J. Biol. Chem. 276 (7): 5228–34. doi:10.1074/jbc.M007542200. PMID 11083865. 
• Till KJ, Lin K, Zuzel M, Cawley JC (2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.". Blood 99 (8): 2977–84. doi:10.1182/blood.V99.8.2977. PMID 11929789. 
• Grant AJ, Goddard S, Ahmed-Choudhury J et al. (2002). "Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease.". Am. J. Pathol. 160 (4): 1445–55. doi:10.1016/S0002-9440(10)62570-9. PMC 1867219. PMID 11943728. 
• Banas B, Wörnle M, Berger T et al. (2002). "Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis.". J. Immunol. 168 (9): 4301–7. doi:10.4049/jimmunol.168.9.4301. PMID 11970971. 
• Christopherson KW, Hood AF, Travers JB et al. (2003). "Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases.". Blood 101 (3): 801–6. doi:10.1182/blood-2002-05-1586. PMID 12393410. 
• Stein JV, Soriano SF, M'rini C et al. (2003). "CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.". Blood 101 (1): 38–44. doi:10.1182/blood-2002-03-0841. PMID 12393730. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Wolf M, Clark-Lewis I, Buri C et al. (2003). "Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.". Am. J. Pathol. 162 (4): 1183–90. doi:10.1016/S0002-9440(10)63914-4. PMC 1851240. PMID 12651610. 
• Weninger W, Carlsen HS, Goodarzi M et al. (2003). "Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis.". J. Immunol. 170 (9): 4638–48. doi:10.4049/jimmunol.170.9.4638. PMID 12707342. 
• Nagakubo D, Murai T, Tanaka T et al. (2003). "A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines.". J. Immunol. 171 (2): 553–61. doi:10.4049/jimmunol.171.2.553. PMID 12847218. 
• Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. 

UpToDate Contents

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English Journal

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• Chadzinska M1, Golbach L2, Pijanowski L3, Scheer M2, Verburg-van Kemenade BM2.
• Developmental and comparative immunology.Dev Comp Immunol.2014 Nov;47(1):68-76. doi: 10.1016/j.dci.2014.07.008. Epub 2014 Jul 15.
• Chemokine and chemokine receptor signalling pairs play a crucial role in regulation of cell migration, morphogenesis, and cell activation. Expressed in mammals on activated T and NK cells, chemokine receptor CXCR3 binds interferon-γ inducible chemokines CXCL9-11 and CCL21. Here we sequenced the car
• PMID 25036761

• Inflammatory cytokines as biomarkers in heart failure.

• Ueland T1, Gullestad L2, Nymo SH3, Yndestad A4, Aukrust P5, Askevold ET6.
• Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2014 Sep 6. pii: S0009-8981(14)00396-9. doi: 10.1016/j.cca.2014.09.001. [Epub ahead of print]
• Inflammation has been implicated in the pathogenesis of heart failure (HF). In addition to their direct involvement as mediators in the pathogenesis of HF, inflammatory cytokines and related mediators could also be suitable markers for risk stratification and prognostication in HF patients. Many rep
• PMID 25199849

• Contribution of Homeostatic Chemokines CCL19 and CCL21 and Their Receptor CCR7 to Coronary Artery Disease.

• Cai W1, Tao J1, Zhang X1, Tian X1, Liu T1, Feng X1, Bai J1, Yan C1, Han Y2.
• Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 Sep;34(9):1933-41. doi: 10.1161/ATVBAHA.113.303081. Epub 2014 Jul 2.
• OBJECTIVE: Our aim was to identify the role of the homeostatic chemokines CCL19 and CCL21 and their common receptor CCR7 in atherogenesis and to study the relationships between CCL19, CCL21, and CCR7 gene variants and coronary artery disease in a Chinese Han population.APPROACH AND RESULTS: Immunohi
• PMID 24990231

Japanese Journal

• The chemotactic interaction between CCL21 and its receptor, CCR7, facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesis

• ZHAO Bin,CUI Kai,WANG Chang-Liang,WANG Ai-Liang,ZHANG Bo,ZHOU Wu-Yuan,ZHAO Wen-Hua,LI Sheng
• Journal of hepato-biliary-pancreatic sciences 18(6), 821-828, 2011-11-01
• NAID 10030241481

• 皮膚のリンパ腫とケモカイン

• 菅谷 誠
• 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 34(2), 91-98, 2011-04-28
• … 関与していることを，これまで我々は報告してきた．これらは皮膚病変部で発現しているだけでなく，血清中でも正常人と比べて上昇しており，病勢マーカーとして有用である．またCXCL9，CXCL10は表皮向性，CCL21はリンパ節への浸潤，CXCL12は腫瘍細胞のCD26発現低下と関係していることが知られている．さらにCXCL13は皮膚へのB細胞の浸潤，CCR3はCD30陽性リンパ増殖症との関与が考えられている．CCR4を治療のターゲットと …
• NAID 10029431944

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• SUGAYA Makoto,REED Stacy,ROSE Patrick P.,DE LA MOTTE Stacy,RAGGO Camilo M.,KURTS Stephen E.,MOSES Ashlee V.,FRUH Klaus,BLAUVELT Andrew
• Journal of dermatological science 61(2), 139-142, 2011-02-01
• NAID 10030890204

Related Links

• Recombinant Human CCL21 (6CKine) - Affymetrix - Japan Home

性状 6Ckineとしても知られるCCL21はケモカインのCCサブファミリーのメンバーです。CCL21はCCL19と最も密接に関連し32%アミノ酸配列 相同性を有します。CCL19とCCL21は主にリンパ節のT cell-rich zoneのストローマ細胞に発現します。

• 受容体 1つの受容体から2つのシグナル｜STKE Japan by ...

1つはCCL21で、これは高内皮細静脈（そこを通ってリンパ球が血液を離れリンパ節に入るように特化した血管）にみられる。もう1つはCCL19で、これはリンパ節のT細胞域（T細胞がB細胞とは分かれて集合している部位）に存在する。CCR7 ...

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