quinolone

出典: meddic

キノロン系抗菌薬

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/02 21:15:10」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/10 00:16:11」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/28 22:17:44」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/28 13:58:20」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/21 04:41:37」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/12/12 22:55:47」(JST)

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英文文献

  • The anticancer effect of PQ1 in the MMTV-PyVT mouse model.
  • Shishido SN, Delahaye A, Beck A, Nguyen TA.Author information Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS.AbstractAnimal models are commonly used to analyze the mechanism of carcinogenesis as well as the development and screening of potent drugs. Here the transgenic strain FVB/N-Tg(MMTV-PyVT)634Mul/J (also known as PyVT) was used as a model system for measuring tumor burden, drug sensitivity, and metastasis of mammary carcinomas. Loss of gap junctional intercellular communication and the down regulation of connexin expression are characteristic of neoplastic cells. The substituted quinoline, 6-methoxy-8-[(3-aminopropyl)amino]-4-methyl-5-(3-trifluoromethyl-phenyloxy)quinolone (PQ1), has been shown to restore GJIC and increase connexin expression in breast cancer cell lines while not affecting normal mammary cells, suggesting that it may provide effective anticancer treatment with less detrimental effects. The PyVT spontaneous mammary tumor mouse model was used to determine the biological and histological effects of PQ1 on tumorigenesis and metastasis at three stages of development: Pretumor, early tumor and late tumor formation. Treatment with PQ1 at all three stages of development significantly reduced tumor growth. PQ1 treatment further increased Cx43 expression during pre- and early-tumor formation, while it prevented an increase in Cx46 expression during late stage tumor formation. This study shows that Cx43 expression and neoplastic cellular growth are inversely related, but that PQ1 can alter tumor growth through targeting gap junction proteins to prove clinical efficacy in the treatment of spontaneous mammary tumors.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 15;134(6):1474-83. doi: 10.1002/ijc.28461. Epub 2013 Sep 19.
  • Animal models are commonly used to analyze the mechanism of carcinogenesis as well as the development and screening of potent drugs. Here the transgenic strain FVB/N-Tg(MMTV-PyVT)634Mul/J (also known as PyVT) was used as a model system for measuring tumor burden, drug sensitivity, and metastasis of
  • PMID 24038078
  • Impact of wastewater treatment processes on antimicrobial resistance genes and their co-occurrence with virulence genes in Escherichia coli.
  • Biswal BK1, Mazza A2, Masson L2, Gehr R1, Frigon D3.Author information 1Department of Civil Engineering and Applied Mechanics, McGill University, Montréal, Québec H3A 0C3, Canada.2National Research Council of Canada, Montréal, Québec H4P 2R2, Canada.3Department of Civil Engineering and Applied Mechanics, McGill University, Montréal, Québec H3A 0C3, Canada. Electronic address: dominic.frigon@mcgill.ca.AbstractAn increase in the frequency of antimicrobial resistance genes (ARGs) in bacteria including Escherichia coli could be a threat to public health. This study investigated the impact of activated sludge and physicochemical wastewater treatment processes on the prevalence of ARGs in E. coli isolates. In total, 719 E. coli were isolated from the influent and effluent (prior to disinfection) of two activated sludge and two physicochemical municipal treatment plants, and genotyped using DNA microarrays. Changes in the abundance of ARGs in the E. coli population were different for the two treatment processes. Activated sludge treatment did not change the prevalence of ARG-possessing E. coli but increased the abundance of ARGs in the E. coli genome while physicochemical treatment reduced both the prevalence of ARG-carrying E. coli as well as the frequency of ARGs in the E. coli genome. Most E. coli isolates from the four treatment plants possessed ARGs of multiple antimicrobial classes, mainly aminoglycoside, β-lactams, quinolone and tetracyclines. In addition these isolates harboured DNA insertion sequence elements including integrase and transposase. A significant positive association was found between the occurrence of ARGs and virulence genotypes.
  • Water research.Water Res.2014 Mar 1;50:245-53. doi: 10.1016/j.watres.2013.11.047. Epub 2013 Dec 12.
  • An increase in the frequency of antimicrobial resistance genes (ARGs) in bacteria including Escherichia coli could be a threat to public health. This study investigated the impact of activated sludge and physicochemical wastewater treatment processes on the prevalence of ARGs in E. coli isolates. In
  • PMID 24380739
  • Antibiotic resistance of Lactobacillus pentosus and Leuconostoc pseudomesenteroides isolated from naturally-fermented Aloreña table olives throughout fermentation process.
  • Casado Muñoz Mdel C1, Benomar N1, Lerma LL1, Gálvez A1, Abriouel H2.Author information 1Área de Microbiología, Departamento de Ciencias de la Salud, Facultad de Ciencias Experimentales, Universidad de Jaén, 23071 Jaén, Spain.2Área de Microbiología, Departamento de Ciencias de la Salud, Facultad de Ciencias Experimentales, Universidad de Jaén, 23071 Jaén, Spain. Electronic address: hikmate@ujaen.es.AbstractAntimicrobial resistance of Lactobacillus pentosus (n=59) and Leuconostoc pseudomesenteroides (n=13) isolated from Aloreña green table olives (which are naturally-fermented olives from Málaga, Spain) to 15 antibiotics was evaluated. Most Lb. pentosus (95%) and all Lc. pseudomesenteroides were resistant to at least three antibiotics. Principal component analysis determined that the prevalence of antibiotic resistance in LAB throughout the fermentation process was highly dependent on the fermenter where the fermentation took place. All Lb. pentosus and Lc. pseudomesenteroides strains were highly sensitive to amoxicillin and ampicillin (MIC≤2μg/ml), and also to chloramphenicol (MIC≤4μg/ml), gentamicin and erythromycin (MIC≤16μg/ml). However, they were phenotypically resistant to streptomycin (83-100%, MIC>256μg/ml), vancomycin and teicoplanin (70-100%, MIC>128μg/ml), trimethoprim (76% of Lb. pentosus and 15% of Lc. pseudomesenteroides, MIC>128μg/ml), trimethoprim/sulfomethoxazol (71-100%, MIC>4-64μg/ml) and cefuroxime (44% of Lb. pentosus and 85% of Lc. pseudomesenteroides, MIC>32-128μg/ml). Lb. pentosus was susceptible to tetracycline and clindamycin, while 46% of Lc. pseudomesenteroides strains were resistant to these antibiotics. Only Lb. pentosus strains were resistant to ciprofloxacin (70%, MIC>4-64μg/ml), although no mutations in the quinolone resistance determining regions of the genes encoding GyrA and ParC were found, thus indicating an intrinsic resistance. Similarly, no genes encoding possible transferable resistance determinants for the observed phenotypic resistance were detected by PCR. In some cases, a bimodal distribution of MICs was observed for some antibiotics to which both LAB species exhibited resistance. Nevertheless, such resistances resulted from an intrinsic mechanism, non-transferable or non-acquired resistance determinants which may in part be due to chromosomally encoded efflux pumps (NorA, MepA and MdeA). Results of the present study demonstrate that all Lb. pentosus and Lc. pseudomesenteroides strains lack transferable resistance-related genes (cat, bla, blaZ, ermA, ermB, ermC, msrA/B, ereA, ereB, mphA, mefA, tet(M), tet(O), tet(S), tet(W), tet(L), tet(K), aad(E), aac(6')-Ie-aph(2')-Ia, aph(2')-Ib, aph(2')-Ic, aph(2')-Id, aph(3')-IIIa, ant(4')-Ia, dfrA, dfrD, vanA, vanB, vanC and vanE) and should therefore, according to Qualified Presumption of Safety criteria, be considered safe for future application as starter cultures or as probiotics.
  • International journal of food microbiology.Int J Food Microbiol.2014 Feb 17;172:110-8. doi: 10.1016/j.ijfoodmicro.2013.11.025. Epub 2013 Dec 3.
  • Antimicrobial resistance of Lactobacillus pentosus (n=59) and Leuconostoc pseudomesenteroides (n=13) isolated from Aloreña green table olives (which are naturally-fermented olives from Málaga, Spain) to 15 antibiotics was evaluated. Most Lb. pentosus (95%) and all Lc. pseudomesenteroides were resi
  • PMID 24370969

和文文献

  • The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans
  • INABA TOMOHIRO,OURA HIROMU,MORINAGA KANA [他]
  • Microbes and environments 30(2), 189-191, 2015-06
  • NAID 40020494189
  • 2-ARYL-4-QUINOLONE SYNTHESIS USING THE THERMAL REARRANGEMENT OF IMINOCYCLOBUTENONES (Dedicated to Professor Isao Kuwajima on the occasion of his 77th birthday)
  • Hachiya Iwao,Yokoyama Keiichi,Ito Akinori [他]
  • Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 90(1), 97-103, 2015-01-01
  • NAID 40020329955
  • Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan
  • MATAYOSHI Masanao,KITANO Takashi,SASAKI Tetsu,NAKAMURA Masaji
  • Journal of Veterinary Medical Science 77(6), 705-710, 2015
  • … The quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE of the quinolone-resistant isolates (n=12) showed amino acid substitutions of Ser-83→Phe or Asp-87→Tyr in GyrA and Ser-107→Ala in ParC. …
  • NAID 130005085866

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The fluoroquinolones have become an increasingly popular class of antibiotics for use in a variety of infections. Newer drugs in this class have been developed with a broader spectrum of activity including better coverage of gram ...

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★リンクテーブル★
リンク元キノロン系抗菌薬
拡張検索fluoroquinolone」「quinolone-resistant Staphylococcus aureus」「respiratory quinolone
関連記事quinolones

キノロン系抗菌薬」

  [★]

quinolone antibacterial agent, quinolone
ピリドンカルボン酸系抗菌薬 pyridone carboxylic acid anti-microbials pyridone carboxylic acid antibacterial agent
抗菌薬ニューキノロン

キノロン系抗菌薬

概念

  • クロロキンを改良してつくられた抗菌薬をキノロン系抗菌薬と呼ぶ。
  • 超らせん構造の維持に関わる酵素とDNAの複合体を安定化し、DNA鎖を切断したままにしておくことにより、生存・細胞分裂を障害する。
  • キノロン系抗菌薬にフッ素を導入して改良した抗菌薬がニューキノロン系抗菌薬である。
  • ニューキノロン系抗菌薬はグラム陰性菌とグラム陽性菌に対して強い抗菌力を有する。

作用機序

副作用

  • 消化器症状:(5-10%)
  • 発疹:(1-2%)
  • 中枢神経症状:(5%)頭痛・浮動性眩暈
  • 軟骨毒性:幼弱な動物で軟骨に異常をきたす → 18歳未満は注意。妊婦には使用しない。 (ABM.106)
  • 日光過敏症
  • 低血糖

適応

第一選択となる適応(IRE.158)




fluoroquinolone」

  [★]

フルオロキノロンフルオロキノロン系


quinolone-resistant Staphylococcus aureus」

  [★] キノロン系耐性黄色ブドウ球菌

respiratory quinolone」

  [★] レスピラトリーキノロン


quinolones」

  [★] キノロン系抗菌薬




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