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quinapril hydrochloride

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/29 17:08:57」(JST)

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  • Modulation of acute transient exercise-induced hypertension after oral administration of four angiotensin-converting enzyme inhibitors in normotensive horses.
  • Muñoz A1, Esgueva M2, Gómez-Díez M2, Serrano-Caballero JM3, Castejón-Riber C2, Serrano-Rodríguez JM3.
  • Veterinary journal (London, England : 1997).Vet J.2016 Feb;208:33-7. doi: 10.1016/j.tvjl.2015.10.036. Epub 2015 Oct 22.
  • Changes in blood pressure (BP) during acute hypertension in response to angiotensin-converting enzyme inhibitors (ACEIs) have not been investigated in normotensive horses. In this study, six healthy horses were subjected to five trials, consisting in a treadmill exercise workload of 8 m/s for 1 
  • PMID 26626097
  • Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.
  • Tarkiainen EK1, Tornio A1, Holmberg MT1, Launiainen T1, Neuvonen PJ1, Backman JT1, Niemi M1.
  • British journal of clinical pharmacology.Br J Clin Pharmacol.2015 Nov;80(5):1131-8. doi: 10.1111/bcp.12667. Epub 2015 Jun 11.
  • AIM: The aim of the present study was to investigate the effects of the carboxylesterase 1 (CES1) c.428G > A (p.G143E, rs71647871) single nucleotide variation (SNV) on the pharmacokinetics of quinapril and enalapril in a prospective genotype panel study in healthy volunteers.METHODS: In a fix
  • PMID 25919042
  • Simultaneous Determination of Eight Hypotensive Drugs of Various Chemical Groups in Pharmaceutical Preparations by HPLC-DAD.
  • Stolarczyk M1, Hubicka U, Żuromska-Witek B, Krzek J.
  • Journal of AOAC International.J AOAC Int.2015 Nov-Dec;98(6):1542-8. doi: 10.5740/jaoacint.15-022.
  • A new sensitive, simple, rapid, and precise HPLC method with diode array detection has been developed for separation and simultaneous determination of hydrochlorothiazide, furosemide, torasemide, losartane, quinapril, valsartan, spironolactone, and canrenone in combined pharmaceutical dosage forms.
  • PMID 26651566


  • Simultaneous determination of hydrochlorothiazide, quinapril and quinaprilat in human plasma by liquid chromatography-tandem mass spectrometry
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 873(1), 59-69, 2008-09-15
  • NAID 10028006496
  • Effects of Angiotensin-Converting Enzyme Inhibitors or an Angiotensin Receptor Blocker in Combination With Aspirin and Cilostazol on In-stent Restenosis
  • Effect of Amlodipine on Vascular Responses After Coronary Stenting Compared With an Angiotensin-Converting Enzyme Inhibitor
  • Circulation journal : official journal of the Japanese Circulation Society 68(4), 328-333, 2004-03-20
  • NAID 110002667534


Before taking quinapril, tell your doctor and pharmacist if you are allergic to quinapril; other ACE inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), enalapril (Vasotec, in Vaseretic), fosinopril (Monopril ...
Quinapril official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... In patients with renal insufficiency, the elimination half-life of Quinaprilat increases as ...


Accupril 40MG (Quinapril) - Genericoval, brown, imprinted with A 244quinapril 10 MG Oral TabletQuinapril pillsquinapril 20 MG Oral TabletAccupril (Quinapril Hydrochloride)

拡張検索quinaprilat」「quinapril hydrochloride



angiotensin-converting enzyme inhibitor angiotensin converting enzyme inhibitor , ACE inhibitor, ACEI
アンジオテンシン変換酵素阻害剤 アンギオテンシン変換酵素阻害薬 アンギオテンシン変換酵素阻害剤 アンジオテンシン転換酵素阻害薬ACE阻害薬 ACE阻害剤 ACE inhibitor、アンギオテンシン変換酵素拮抗薬, アンギオテンシン変換酵素拮抗薬, angiotensin-converting enzyme antagonist
アンジオテンシン, アンジオテンシン転換酵素 ACE, 1型アンジオテンシンII受容体拮抗薬 アンジオテンシンII受容体拮抗薬 ARB


薬剤名 成分名 高血圧 腎性高血圧 腎血管性高血圧 悪性高血圧 慢性心不全 1型糖尿病に伴う糖尿病性腎症
レニベース エナラプリル  
ロンゲス リシノプリル        
タナトリル イミダプリル      
エースコール テモカプリル      
コバシル ペリンドプリル           


  • 咳嗽:ACEブラジキニンを分解するキニナーゼIIと同一の酵素である。ACE阻害薬はこの酵素を阻害するが、ブラジキニンは血管拡張、血漿滲出、発痛作用に関わっている。このため咳を誘発することがある。
  • 高カリウム血症:間接的に血漿中のレニン濃度が低下するためにナトリウム取り込みとカリウム排泄が低下して高カリウム血症を来す
  • 低血圧
  • 腎不全


  • 妊婦
  • 両側性腎動脈狭窄のある患者
  • 腎血流量の減少や糸球体ろ過圧の低下により急速に腎機能を悪化させるおそれ。アンジオテンシンIIによる輸出細動脈の収縮作用がblockされ、両腎共に腎血流が減少しているためにGFRの低下を代償できず腎機能の悪化をきたす。





塩酸キナプリル quinapril hydrochloride
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quinapril hydrochloride」