偽コリンエステラーゼ
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- 1. 麻酔導入時の神経筋遮断薬の使用clinical use of neuromuscular blocking agents in anesthesia [show details]
…administered until return of neuromuscular function has been documented, as confirmation of normal pseudocholinesterase activity. Nondepolarizing NMBAs do not cause fasciculations. Therefore, we suggest the use …
- 2. 有機リン剤およびカルバメート中毒organophosphate and carbamate poisoning [show details]
…antidotal oxime . In addition, plasma cholinesterase (also called butylcholinesterase [BuChE] or pseudocholinesterase) and neuropathy target esterase (NTE) are inhibited by organophosphorus agents; however, the…
- 3. 臨床使用する局所麻酔薬についてclinical use of local anesthetics in anesthesia [show details]
…cholinesterase, and conditions in which cholinesterase activity is reduced (ie, atypical pseudocholinesterase or pseudocholinesterase deficiency) theoretically predispose to reduced metabolism. In one case report …
- 4. 局所麻酔の全身毒性local anesthetic systemic toxicity [show details]
…using chloroprocaine . Plasma half-life of chloroprocaine may be prolonged in patients with pseudocholinesterase deficiency and in patients who take anticholinesterase medication (eg, pyridostigmine for …
- 5. 危篤状態の患者への神経筋遮断薬の使用clinical use of neuromuscular blocking agents in critically ill patients [show details]
English Journal
- Biochemical blood markers and sampling sites in forensic autopsy.
- Uemura K, Shintani-Ishida K, Saka K, Nakajima M, Ikegaya H, Kikuchi Y, Yoshida K.
- Journal of forensic and legal medicine. 2008 Jul;15(5)312-7.
- Forensic pathologists often hesitate to use biochemical blood markers due to the risk of large postmortem changes and deviations from healthy subjects. Biochemical analyses of postmortem blood, if possible, may help to evaluate pathological status and determining the cause of death in forensic diagn
- PMID 18511006
- Evaluation of nitrate-substituted pseudocholine esters of aspirin as potential nitro-aspirins.
- Gilmer JF, Moriarty LM, Clancy JM.
- Bioorganic & medicinal chemistry letters. 2007 Jun;17(11)3217-20.
- Herein we explore some designs for nitro-aspirins, compounds potentially capable of releasing both aspirin and nitric oxide in vivo. A series of nitrate-bearing alkyl esters of aspirin were prepared based on the choline ester template preferred by human plasma butyrylcholinesterase. The degradation
- PMID 17376682
- Identifying enzyme activities within human saliva which are relevant to dental resin composite biodegradation.
- Lin BA, Jaffer F, Duff MD, Tang YW, Santerre JP.
- Biomaterials. 2005 Jul;26(20)4259-64.
- Esterase activities similar to those of cholesterol and pseudocholine esterases (CE and PCE, respectively) have been detected within whole human saliva. Since commercial CE has been shown to possess distinct activity relative to PCE for select components in dental composites, it is hypothesized that
- PMID 15683649
Japanese Journal
- 血清Carboxyl esteraseとリポタンパク代謝(I)
- 白井 厚治,大沢 育子,松岡 信夫,西出 敏雄,斎藤 康,吉田 尚
- 動脈硬化 12(6), 1513-1517, 1985
- … The role of serum carboxyl esterase on lipoprotein metabolism was investigated. … Serum carboxylesterase levels were well correlated with the level of total cholesterol and triglyceride, suggesting that carboxyl esterase is secreted from the liver accompanying with the secretion of very low density lipoprotein. … <sup>125</sup>I-carboxyl esterase was incorporated into rat peritoneal macrophage, and transferred to the area where acid lipase existed. …
- NAID 130006852291
- 血清および十二指腸液中Lipaseの合成基質 (α-Naphthyl Palmitate) による簡易測定法
- 原納 優,高月 權一,日高 秀樹,繁田 幸男,平田 文雄,杉山 正康,田村 澄洋
- 臨床化学 7(4), 350-356, 1979
- … Only minor activity was noted for the commertial pseudocholine esterase and liver esterase. … However, in hepatitis with marked elevation of plasma GOT or GP r, normal level of plasma lipase was observed, and no elevation of lipase activity was found in plasma with elevated pseudocholine esterase activity.<BR>In acute pancreatitis, plasma lipase activity was elevated by 7-30 fold and the elevation seemed to be greater than that of amylase. …
- NAID 130003357185
- 奥田 拓道,牧 三郎,村岡 俊春,斎藤 康,松岡 信夫,熊谷 朗,白井 厚治
- 動脈硬化 5(4), 409-415, 1978
- … Pseudocholine esterase was purified from human serum and was demonstrated to be identical with the non-specific esterase. … When the purified esterase was incubated with slices of rat aorta which was pretreated with heparin to remove lipase, remarkable elevation of lipase activity was observed. … The recovery of lipase activity by addition of the esterase was also confirmed by histochemical method. …
- NAID 130006853303
Related Links
- Pseudocholinesterase deficiency is a condition that results in increased sensitivity to certain muscle relaxant drugs used during general anesthesia, called choline esters. These fast-acting drugs, such as succinylcholine and ...
- Pseudocholinesterase deficiency causes and anesthesia, drugs to avoid, test & carrier diagnosis, treatment. Pseudocholinesterase deficiency can be caused by mutations in the BCHE gene. ... [Source 18)] The complete DNA ...
- Pseudocholinesterase deficiency is an inherited enzyme abnormality that results in abnormally slow metabolic degradation of exogenous choline ester drugs such as succinylcholine. A variety of pathologic conditions ...
★リンクテーブル★
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- 英
- suxamethonium
- 同
- サクシニルコリン succinylcholine、塩化サクシニルコリン succinylcholine chloride, SCC
- 化
- 塩化スキサメトニウム suxamethonium chloride
- 商
- サクシン、レラキシン、Anectin
- 関
- 薬理学
[show details]
分類
構造
作用機序
薬理作用
動態
適応
- 気管内挿管時・骨折脱臼の整復時・喉頭痙攣の筋弛緩
- 精神神経科における電撃療法の際の筋弛緩
- 腹部腫瘤診断時
注意
禁忌
副作用
- SAN.71改変
- 1. 筋肉痛：強い攣縮が起こるために筋痛をきたす。
- a) 外眼筋攣縮：眼圧亢進を来たし、緑内障を生ずることがある。この眼圧亢進は投与後1-6分で5-10mmHgほど上昇
- b) 脳圧亢進
- c) 腹筋の攣縮：胃内圧亢進を来たす。
- 治療：ダントロレン：筋小胞体からのカルシウム遊離を阻害
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エステラーゼ、エステル加水分解酵素、エステル分解酵素