prion protein

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/22 11:57:20」(JST)

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  • A two population model of prion transport through a tunnelling nanotube.
  • Kuznetsov IA1, Kuznetsov AV.
  • Computer methods in biomechanics and biomedical engineering.Comput Methods Biomech Biomed Engin.2014 Nov;17(15):1705-15. doi: 10.1080/10255842.2013.763938. Epub 2013 Mar 12.
  • This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the
  • PMID 23477810
  • Genetic prion disease: no role for the immune system in disease pathogenesis?
  • Friedman-Levi Y1, Binyamin O1, Frid K1, Ovadia H1, Gabizon R2.
  • Human molecular genetics.Hum Mol Genet.2014 Aug 1;23(15):4134-41. doi: 10.1093/hmg/ddu134. Epub 2014 Mar 25.
  • Prion diseases, which can manifest by transmissible, sporadic or genetic etiologies, share several common features, such as a fatal neurodegenerative outcome and the aberrant accumulation of proteinase K (PK)-resistant PrP forms in the CNS. In infectious prion diseases, such as scrapie in mice, prio
  • PMID 24667414
  • Caffeine prevents human prion protein-mediated neurotoxicity through the induction of autophagy.
  • Moon JH1, Lee JH1, Park JY1, Kim SW1, Lee YJ1, Kang SJ2, Seol JW1, Ahn DC1, Park SY1.
  • International journal of molecular medicine.Int J Mol Med.2014 Aug;34(2):553-8. doi: 10.3892/ijmm.2014.1814. Epub 2014 Jun 18.
  • The human prion protein (PrP) fragment PrP(106‑126) possesses the majority of the pathogenic properties associated with the infectious scrapie isoform of PrP, known as PrPSc. The accumulation of PrPSc in the brain of humans and animals affects the central nervous system. Recent epidemiological stu
  • PMID 24938171


  • Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases
  • Takatsuki Hanae,Satoh Katsuya,Sano Kazunori,Fuse Takayuki,Nakagaki Takehiro,Mori Tsuyoshi,Ishibashi Daisuke,Mihara Ban,Takao Masaki,Iwasaki Yasushi,Yoshida Mari,Atarashi Ryuichiro,Nishida Noriyuki
  • PLOS ONE 10(6), e0126930, 2015-06-12
  • … The infectious agents of the transmissible spongiform encephalopathies are composed of amyloidogenic prion protein, PrPSc. … This new method for quantitation of human prion activity provides a new way to reduce the risk of iatrogenic prion transmission. …
  • NAID 120005625368
  • 微量元素と神経疾患:疾患関連タンパク質と金属とのシナプス間隙における相互作用
  • 川原 正博,水野 大
  • Biomedical Research on Trace Elements 26(1), 10-22, 2015
  • … Increasing evidence suggests that dyshomeostasis of trace elements are implicated in the pathogenesis of various neurodegenerative diseases such as Alzheimer's disease, prion diseases, and dementia with Lewy bodies. … These diseases share similarity in the formation ofβ-sheet containing amyloid fibrils by disease-related proteins includingβ-amyloid protein (AβP), prion protein, α-synuclein, polyglutamine, and the introduction of apoptotic degeneration. …
  • NAID 130005072343
  • Descriptive Epidemiology of Prion Disease in Japan: 1999–2012
  • Nakamaura Yosikazu,Ae Ryusuke,Takumi Ichiro,Sanjo Nobuo,Kitamoto Tetsuyuki,Yamada Masahito,Mizusawa Hidehiro
  • Journal of Epidemiology 25(1), 8-14, 2015
  • … Background: Epidemiologic features of prion diseases in Japan, in particular morbidity and mortality, have not been clarified.<BR>Methods: Since 1999, the Research Committee has been conducting surveillance of prion diseases, and the surveillance data were used to assess incident cases of prion diseases. …
  • NAID 130004851879


A blending of previous test concepts by NIAID scientists has led to the development of a new prion-detection method, called real-time quaking-induced conversion assay, or RT-QuIC, which can detect when miniscule amounts of ...
The official name of this gene is “prion protein.” PRNP is the gene's official symbol. The PRNP gene is also known by other names, listed below. Read more about gene names and symbols on the About page.



拡張検索scrapie prion protein」「normal prion protein」「abnormal prion protein



prion protein
prion protein
prion-related protein
prion protein



prion proteinPrP



prion protein

scrapie prion protein」


PrP-resPrPSc protein

normal prion protein」


PrP-senPrPC protein

abnormal prion protein」

  [★] 異常プリオン蛋白


  [★] 蛋白質

WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

PrepTutorEJDIC   license prepejdic



  [★] プリオン

WordNet   license wordnet

「(microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system」