関: perazine dimalonate、perazine fendizoate、perazine maleate

WordNet

antipsychotic and antiemetic drug used to treat schizophrenia and to combat nausea and vomiting

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/09 15:13:38」(JST)

wiki en

Perazine (Taxilan) is a moderate-potency typical antipsychotic of the phenothiazine class. It is quite similar to chlorpromazine, and acts as a dopamine antagonist.

References

External links

Perazine at the US National Library of Medicine Medical Subject Headings (MeSH)

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

English Journal

Haloperidol versus first-generation antipsychotics for the treatment of schizophrenia and other psychotic disorders.

Dold M1, Samara MT, Li C, Tardy M, Leucht S.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2015 Jan 16;1:CD009831. doi: 10.1002/14651858.CD009831.pub2.
BACKGROUND: Haloperidol is worldwide one of the most frequently used antipsychotic drugs with a very high market share. Previous narrative, unsystematic reviews found no differences in terms of efficacy between the various first-generation ("conventional", "typical") antipsychotic agents. This estab
PMID 25592299

Pharmacogenetics of adverse events in schizophrenia treatment: comparison study of ziprasidone, olanzapine and perazine.

Tybura P1, Trześniowska-Drukała B1, Bienkowski P2, Beszlej A3, Frydecka D3, Mierzejewski P2, Samochowiec A4, Grzywacz A1, Samochowiec J5.
Psychiatry research.Psychiatry Res.2014 Oct 30;219(2):261-7. doi: 10.1016/j.psychres.2014.05.039. Epub 2014 Jun 2.
The primary aim of the present study was to assess the possible associations between dopaminergic, serotonergic, and glutamatergic system-related genes and adverse events after antipsychotic treatment in paranoid schizophrenia patients. The second aim of the study was to compare the intensity of the
PMID 24930580

Perazine for schizophrenia.

Leucht S1, Helfer B, Hartung B.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2014 Jan 15;1:CD002832. doi: 10.1002/14651858.CD002832.pub3.
BACKGROUND: Perazine is an old phenothiazine derivative used for the treatment of people with schizophrenia and is reputed to have a low level of extrapyramidal adverse effects. As far as we are aware, its use is limited to Germany, Poland, the former Yugoslavia and the Netherlands.OBJECTIVES: To ex
PMID 24425538

Japanese Journal

Simple and simultaneous determination for twelve phenothiazines in human serum by reversed-phase high-performance liquid chromatography

TANAKA Einosuke,NAKAMURA Takako,TERADA Masaru,SHINOZUKA Tatsuo,HASHIMOTO Chikako,KURIHARA Katsuyoshi,HONDA Katsuya
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 854(1), 116-120, 2007-07-01
… A high-performance liquid chromatographic method has been developed for the simultaneous analysis of the 12 phenothiazines (chlorpromazine, fluphenazine, levomepromazine, perazine, perphenazine, prochlorperazine, profenamine, promethazine, propericiazine, thioproperazine, thioridazine and trifluoperazine) in human serum using HPLC/UV. …
NAID 10025805017

Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection

SACHSE Julia,KOLLER Johannes,HARTTER Sebastian,HIEMKE Christoph
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 830(2), 342-348, 2006-01-18
NAID 10025778688

A Simple Spectrophotometric Determination of Some Phenothiazine Drugs in Pharmaceutical Samples

Nagaraja Padmarajaiah,Dinesh Nandipura D.,Made Gowda Netkal M. [他],RANGAPPA Kanchugarakoppal S.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 16(11), 1127-1131, 2000-11-10
… The proposed method is based on the reaction of promethazine hydrochloride (PH), chlorpromazine hydrochloride (CPH), triflupromazine hydrochloride (TPH), fluphenazine hydrochloride (FPH), trifluoperazine hydrochloride (TFPH), perazine dimaleate (PDM) and prochlorperazine maleate (PCPM) with iron(III) and a subsequent reaction with ferricyanide in an acetic acid medium to yield Prussian blue colored product with a maximum absorption at 700-720 nm. …
NAID 10006675852

Related Pictures

★リンクテーブル★

リンク元	「ペラジン」「perazine fendizoate」「perazine dimalonate」
拡張検索	「perazine maleate」「thiethylperazine maleate」「piperazine phosphate」「butaperazine maleate」「prochlorperazine」

「ペラジン」

Perazine
Systematic (IUPAC) name
	10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	84-97-9
ATC code	N05AB10
PubChem	CID: 4744
ChemSpider	4582
UNII	8915147A2B
ChEBI	CHEBI:59118
Chemical data
Formula	C20H25N3S
Molecular mass	339.498 g/mol
	SMILES CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=CC=CC=C42;
	InChI InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3 ; Key:WEYVCQFUGFRXOM-UHFFFAOYSA-N ;
(what is this?) (verify)