oxidized LDL cholesterol

　

WordNet

1. LDL cholesterol that has been bombarded by free radicals; it is thought to cause atherosclerosis
2. an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues (同)cholesterin
3. the 12th letter of the Roman alphabet (同)l
4. combined with or having undergone a chemical reaction with oxygen; "the oxidized form of iodine" (同)oxidised

PrepTutorEJDIC

1. コレステロール(胆汁・血液・神経組織などの脂肪性成分)
2. lira(イタリアの貨幣単位リラ)
3. lethal dose(薬の)最小致死量

UpToDate Contents

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• 1. 心血管疾患の危険因子の概要 overview of possible risk factors for cardiovascular disease
• 2. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis
• 3. アテローム性動脈硬化症の病因 pathogenesis of atherosclerosis
• 4. リポ蛋白aと心血管疾患 lipoprotein a and cardiovascular disease
• 5. Familial hypercholesterolemia in adults: Treatment

English Journal

• Curcumin ameliorates atherosclerosis through upregulation of miR-126.

• Li Y, Tian L, Sun D, Yin D.
• Journal of cellular physiology. 2019 Nov;234(11)21049-21059.
• The potential usage of curcumin in diverse human diseases has been widely studied, including arteriosclerosis (AS). This study focused on investigating the relationship between curcumin and AS-associated microRNA, which may provide a better understanding of curcumin in a different mechanism. Human m
• PMID 31016760

• Bis(monoacylglycero)phosphate regulates oxysterol binding protein-related protein 11 dependent sterol trafficking.

• Arnal-Levron M, Chen Y, Greimel P, Calevro F, Gaget K, Riols F, Batut A, Bertrand-Michel J, Hullin-Matsuda F, Olkkonen VM, Delton I, Luquain-Costaz C.
• Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 Sep;1864(9)1247-1257.
• Bis(Monoacylglycero) Phosphate (BMP) is a unique phospholipid localized in late endosomes, a critical cellular compartment in low density lipoprotein (LDL)-cholesterol metabolism. In previous work, we demonstrated the important role of BMP in the regulation of macrophage cholesterol homeostasis. BMP
• PMID 31136841

• Macrophage lipid accumulation in the presence of immunosuppressive drugs mycophenolate mofetil and cyclosporin A.

• Voloshyna I, Teboul I, Kasselman LJ, Salama M, Carsons SE, DeLeon J, Mattana J, Miyawaki N, Reiss AB.
• Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2019 Sep;68(9)787-799.
• Mycophenolate (MPA) and cyclosporin A (CsA) are two immunosuppressive agents currently used for the treatment of autoimmune diseases. However, reports regarding their effects on inflammation and lipid handling are controversial. Here, we compare the effect of these two drugs on the expression of pro
• PMID 31227843

Japanese Journal

• Protective Effect of Saponins-Enriched Fraction of <i>Gynostemma pentaphyllum</i> against High Choline-Induced Vascular Endothelial Dysfunction and Hepatic Damage in Mice

• Yang Chengcheng,Zhao Yan,Ren Daoyuan,Yang Xingbin
• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 43(3), 463-473, 2020
• … <p>Choline as a quaternary amine nutrient is metabolized to trimethylamine by gut microbiota and subsequently oxidized to circulating trimethylamine-<i>N</i>-oxide (TMAO), a gut-derived metabolite associated with liver toxicity and cardiovascular disease. …
• NAID 130007804430

• 5-Aminolevulinic Acid Attenuates Atherosclerotic Plaque Progression in Low-Density Lipoprotein Receptor-Deficient Mice by Heme Oxygenase-1 Induction

• Hagisawa Kohsuke,Ayaori Makoto,Ikewaki Katsunori,Nakajima Motowo,Morimoto Yuji
• Circulation Reports 2(1), 60-68, 2020
• … Hence, the aim of this study was to determine the anti-atherosclerotic effect of ALA.</p><p><b><i>Methods and Results:</i></b>Low-density lipoprotein (LDL) receptor knockout mice were fed the following diets for 24 weeks: normal diet (n=6); … 1.25% cholesterol diet (high-cholesterol diet, HCD; …
• NAID 130007784341

• A Novel Cell-Free, Non-Fluorescent Method to Measure LOX-1-Binding Activity Corresponding to The Functional Activity of HDL

• Kakino Akemi,Usami Yoko,Horiuchi Sayaka,Fujita Yoshiko,Kotani Kazuhiko,Chen Chu-Huang,Okamura Tomonori,Sawamura Tatsuya
• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 26(11), 947-958, 2019
• … A functional abnormality in high-density lipoprotein (HDL) particles rather than a quantitative abnormality in HDL cholesterol levels has been suggested to promote atherosclerosis. … The modification of HDL may underlie functional changes to HDL such as gaining the ability to bind and activate the lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1). …
• NAID 130007740412

Related Links

• The Effects of Oxidized LDL Cholesterol

Learn how oxidized LDL cholesterol is an emerging risk factor that could place you at risk for vascular disease, heart disease, and stroke. Working to lower your overall LDL cholesterol level. In some cases, you may need medication to do this. to do this.

• Oxidized Cholesterol: What You Should Know

Oxidized cholesterol can lead to heart disease. Learn more about this dangerous form of cholesterol. There are three main ways oxidized cholesterol builds up in your bloodstream: eating ...

• Oxidized Low-Density Lipoprotein

Oxidized low-density lipoprotein (Ox-LDL) has been studied for over 25 years. Numerous pro- and anti-atherogenic properties have been attributed to Ox-LDL. Yet, Ox-LDL has neither been defined nor characterized, as its components and composition change ...

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★リンクテーブル★

関連記事	「LDL」「LD」「oxidized LDL」「L」「oxidize」

「LDL」

　　[★]

同

low density lipoprotein

関

低密度リポ蛋白、低密度リポタンパク、低密度リポタンパク質

関

• VLDLより由来し、これに含まれるTGがLPLにより分解されて比較的密度の高いLDLが生じる
• 60%コレステロール、5%トリグリセロール、主要なアポリポ蛋白はapoE

「LD」

　　[★]

• 学習障害 learning disability
• 背外側核 dorsolateral nucleus
• 連鎖不平衡 linkage disequilibrium
• 乳酸脱水素酵素 lactate dehydrogenase

　

「oxidized LDL」

　　[★]

• 酸化低密度リ・タンパク質、酸化低比重リ・タンパク質、酸化LDL

関

oxidized low-density lipoprotein、oxLDL

「L」

　　[★]

• リシジン
• リンキング数
• ロイシン
• free ligand concentration

　 　

「oxidize」

　　[★]

• 酸化する

関

oxidation、oxidised、oxidizable、oxidization