WordNet

natural process that causes something to form; "the formation of gas in the intestine"; "the formation of crystals"; "the formation of pseudopods"
the act of fabricating something in a particular shape (同)shaping
a particular spatial arrangement
creation by mental activity; "the formation of sentences"; "the formation of memories"
an arrangement of people or things acting as a unit; "a defensive formation"; "a formation of planes"
cell that functions in the breakdown and resorption of bone tissue

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1. 乳癌による骨転移のマネージメントにおける骨吸収抑制剤 osteoclast inhibitors in the management of bone metastases from breast cancer
2. 骨格の正常な発達および骨形成ならびに骨吸収の調節 normal skeletal development and regulation of bone formation and resorption
3. 進行前立腺癌における骨転移：マネージメント bone metastases in advanced prostate cancer management
4. 進行癌患者における骨吸収抑制薬による薬剤療法のリスク risks of therapy with bone antiresorptive agents in patients with advanced malignancy
5. 骨粗鬆症の病因 pathogenesis of osteoporosis

Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation.

Golovchenko S, Hattori T, Hartmann C, Gebhardt M, Gebhard S, Hess A, Pausch F, Schlund B, von der Mark K.SourceDept. of Experimental Medicine I, University of Erlangen-Nuremberg, Germany.
Bone.Bone.2013 Jul;55(1):102-12. doi: 10.1016/j.bone.2013.03.019. Epub 2013 Apr 6.
In order to elucidate the role of β-catenin in hypertrophic cartilage zone of the growth plate, we deleted the β-catenin gene ctnnb1specifically from hypertrophic chondrocytes by mating ctnnb1(fl/fl) mice with BAC-Col10a1-Cre-deleter mice. Surprisingly, this resulted in a significant reduction
PMID 23567158

Effects of pharmacological inhibition of cathepsin K on fracture repair in mice.

Soung do Y, Gentile MA, Duong le T, Drissi H.SourceNew England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, CT 06030, USA.
Bone.Bone.2013 Jul;55(1):248-55. doi: 10.1016/j.bone.2013.02.010. Epub 2013 Feb 26.
Cathepsin K inhibitors (CatK-I) have been developed and established to restore bone mass in both animal models of bone loss and postmenopausal osteoporotic patients. We investigated the effects of a CatK-I L-006235 on bone repair and compared to alendronate (ALN) for its known effects on fracture he
PMID 23486186

The beneficial effect of Icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats.

Peng S, Zhang G, Zhang BT, Guo B, He Y, Bakker AJ, Pan X, Zhen W, Hung L, Qin L, Leung WN.SourceDepartment of Spine Surgery, Shenzhen People's Hospital, Jinan University Second College of Medicine, Shenzhen, China.
Bone.Bone.2013 Jul;55(1):230-40. doi: 10.1016/j.bone.2013.02.012. Epub 2013 Feb 26.
BACKGROUND: Epimedium-derived flavonoids (EFs) have a potential to treat established osteoporosis in postmenopausal women. However, one of the main disadvantages of the compound is the high volume and dosage during long-term administration period. Meanwhile, the beneficial effect of EFs on osteoporo
PMID 23486180

Effect of Cytokines on Osteoclast Formation and Bone Resorption during Mechanical Force Loading of the Periodontal Membrane

Kitaura Hideki,Kimura Keisuke,Ishida Masahiko,Sugisawa Haruki,Kohara Haruka,Yoshimatsu Masako,Takano-Yamamoto Teruko
The Scientific World Journal 2014, 1-7, 2014-01-19
… In TNF-receptor-deficient mice, there was less tooth movement and osteoclast numbers were lower than in wild-type mice. … These results suggest that osteoclast formation and bone resorption caused by loading forces on the periodontal ligament depend on TNF-α. … Studies have found that inflammatory cytokines such as IL-12 and IFN-γ strongly inhibit osteoclast formation and tooth movement. …
NAID 120005438838

河岸洋和
日本きのこ学会誌 : mushroom science and biotechnology 21(1), 11-15, 2013-04-30
筆者らのきのこ2次代謝産物に関する化学的研究を紹介する.ヤマブシタケ,ブナハリタケ,オオシロアリタケ,アカヤマドリ,サケツバタケから小胞体ストレス抑制物質を得た.茶樹茸,アンニンコウから破骨細胞形成抑制物質を得た.「フェアリーリング」を引き起こすコムラサキシメジの菌糸体からは,試した全ての植物の成長を制御する活性物質を得ることに成功した.フミヅキタケ培養菌糸体からは,レタス幼苗の胚軸の生長を阻害す …
NAID 110009604522

尾下浩一,山岡邦宏,田中良哉
産業医科大学雑誌 35(1), 33-37, 2013-03-01
関節リウマチ(rheumatoid arthritis ; RA)において不可逆的に進行する骨・軟骨破壊によって生じる関節変形は,患者の運動機能を著しく低下させる.したがって,関節滑膜の炎症制御だけでなく破壊関節の修復・再生を可能とする新しい治療法の開発が急務である.近年,骨芽細胞や軟骨細胞に分化誘導可能かつ免疫抑制作用を有する間葉系幹細胞(mesenchymal stem cell ; MSC) …
NAID 110009593199