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1. アロマターゼ阻害剤による骨量減少の評価およびマネージメント evaluation and management of aromatase inhibitor induced bone loss
2. 骨格の正常な発達および骨形成ならびに骨吸収の調節 normal skeletal development and regulation of bone formation and resorption
3. 痛風性関節炎の病態生理 pathophysiology of gouty arthritis
4. 骨粗鬆症に対するデノスマブ denosumab for osteoporosis
5. ステロイド誘発性骨粗鬆症の病因、臨床的特徴、および評価 pathogenesis clinical features and evaluation of glucocorticoid induced osteoporosis

English Journal

Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy.

Shi J1, Wang L1, Zhang H1, Jie Q1, Li X1, Shi Q2, Huang Q1, Gao B1, Han Y1, Guo K1, Liu J3, Yang L4, Luo Z5.
Bone.Bone.2015 Oct;79:222-32. doi: 10.1016/j.bone.2015.06.014. Epub 2015 Jun 24.
Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of gl
PMID 26115910

CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo.

Kim JY1, Min JY2, Baek JM2, Ahn SJ2, Jun HY1, Yoon KH3, Choi MK4, Lee MS5, Oh J6.
Bone.Bone.2015 Oct;79:242-51. doi: 10.1016/j.bone.2015.06.011. Epub 2015 Jun 21.
Adipokines derived from adipocytes are important factors that act as circulating regulators of bone metabolism. C1q/tumor necrosis factor (TNF)-related Protein-3 (CTRP3) is a novel adipokine with multiple effects such as lowering glucose levels, inhibiting gluconeogenesis in the liver, and increasin
PMID 26103094

Bone marrow ablation demonstrates that estrogen plays an important role in osteogenesis and bone turnover via an antioxidative mechanism.

Shi C1, Wu J1, Yan Q1, Wang R1, Miao D2.
Bone.Bone.2015 Oct;79:94-104. doi: 10.1016/j.bone.2015.05.034. Epub 2015 May 31.
To assess the effect of estrogen deficiency on osteogenesis and bone turnover in vivo, 8-week-old mice were sham-operated or bilaterally ovariectomized (OVX), and after 8weeks, mechanical bone marrow ablation (BMX) was performed and newly formed bone tissue was analyzed from 6days to 2weeks after BM
PMID 26036172