- 関
- nucleoside reverse transcriptase inhibitors. specific agents
WordNet
- of the transmission gear causing backward movement in a motor vehicle; "in reverse gear"
- a relation of direct opposition; "we thought Sue was older than Bill but just the reverse was true" (同)contrary, opposite
- the gears by which the motion of a machine can be reversed (同)reverse gear
- the side of a coin or medal that does not bear the principal design (同)verso
- (American football) a running play in which a back running in one direction hands the ball to a back running in the opposite direction
- an unfortunate happening that hinders or impedes; something that is thwarting or frustrating (同)reversal, setback, blow, black_eye
- a substance that retards or stops an activity
- a lapel on a womans garment; turned back to show the reverse side (同)revere
- turned inside out and resewn; "the reversed collar looked as good as new"
- the enzyme that copies DNA into RNA (同)RNA_polymerase
PrepTutorEJDIC
- (位置・方向・順序などにおいて)『逆の』;裏側の』 / 逆に動かす(動く),バックの / 〈U〉《the reverse》(…の)『反対』,『逆』《+『of』+『名』(『wh』‐節)》》 / 〈U〉《the reverse》(貨幣・メダルなどの)『裏側』,(一般に)(…の)裏面《+『of』+『名』》 / 〈C〉(運命などの)逆転,不運 / 〈U〉後退[装置],逆転[装置] / …‘を'『逆にする』,反対にする;…‘を'裏返す / 〈機械など〉‘を'逆転させる,逆方向に動かす / 〈判決など〉‘を'取り消す,破棄する / (ダンスで)逆に回る / 〈機械などが〉逆方向に動く
- 抑制する人(物) / 化学反応抑制剤
- (フランス語)(えりの)裏出し,折り返し
- 逆にした,反対の,裏返のし;取り消された
UpToDate Contents
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English Journal
- Bone and vitamin D metabolism in HIV.
- Panayiotopoulos A, Bhat N, Bhangoo A.SourceDepartment of Pediatric Endocrinology, Children's Hospital at SUNY Downstate, Kings County Hospital Center, and Infants and Children's Hospital at Maimonides, 977 48th Street, Brooklyn, NY, 11219, USA.
- Reviews in endocrine & metabolic disorders.Rev Endocr Metab Disord.2013 May 9. [Epub ahead of print]
- Human immunodeficiency virus (HIV) infection has progressed to a chronic disease and HIV positive individuals are living longer lives. This has lead to an increase in morbidity and mortality due to secondary issues, one being HIV bone disease. HIV infected pediatric and adult populations have a grea
- PMID 23657562
- Basolateral Uptake of Nucleosides by Sertoli Cells is Mediated Primarily by Equilibrative Nucleoside Transporter 1 (ENT1).
- Klein DM, Evans KK, Hardwick RN, Dantzler WH, Wright SH, Cherrington NJ.Source1 University of Arizona, Department of Pharmacology and Toxicology;
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2013 May 2. [Epub ahead of print]
- The blood-testis barrier (BTB) prevents the entry of many xenobiotic compounds into seminiferous tubules thereby protecting developing germ cells. Understanding drug transport across the BTB may improve drug delivery into the testis. Members of one class of drug, nucleoside reverse transcriptase inh
- PMID 23639800
- Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
- James CA, Deroy P, Duplessis M, Edwards PJ, Halmos T, Minville J, Morency L, Morin S, Simoneau B, Tremblay M, Bethell R, Cordingley M, Duan J, Lamorte L, Pelletier A, Rajotte D, Salois P, Tremblay S, Sturino CF.SourceBoehringer Ingelheim (Canada) Ltd, Research and Development, 2100 Cunard Street, Laval, Québec, Canada H7S 2G5. Electronic address: clint.james@boehringer-ingelheim.com.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 May 1;23(9):2781-6. doi: 10.1016/j.bmcl.2013.02.021. Epub 2013 Feb 13.
- A HTS screen led to the identification of a benzofurano[3,2-d]pyrimidin-2-one core structure which upon further optimization resulted in 1 as a potent HIV-1 nucleotide competing reverse transcriptase inhibitor (NcRTI). Investigation of the SAR at N-1 allowed significant improvements in potency and w
- PMID 23545107
Japanese Journal
- 鯉渕 智彦
- ウイルス 63(2), 199-208, 2013
- … strand transfer inhibitor),侵入阻害薬(CCR5阻害薬)に大別され,さらに逆転写酵素阻害薬はヌクレオシド系(NRTI: nucleoside/nucleotide reverse transcriptase inhibitor)と非ヌクレオシド系(NNRTI: non-nucleoside reverse transcriptase inhibitor) に分けられる.異なる作用機序の薬剤を適切に組み合わせれば長期的にHIVの増殖を抑制できる.近年の抗HIV薬は強力 …
- NAID 130004713425
- Accelerated Evolution of Fetuin Family Proteins in Protobothrops flavoviridis (Habu Snake) Serum and the Discovery of an L1-Like Genomic Element in the Intronic Sequence of a Fetuin-Encoding Gene
- TANAKA Yasuyoshi,OYAMA Sachiko,HORI Shin-ichi,USHIO Koya,SHIOI Narumi,TERADA Shigeyuki,DESHIMARU Masanobu
- Bioscience, Biotechnology, and Biochemistry 77(3), 582-590, 2013
- … A comparison of their cDNAs and intronic sequences revealed that nucleotide substitutions were primarily in protein-coding regions, and the substitution patterns indicated accelerated evolution of these proteins. … This segment retains an open reading frame (ORF) that encodes a reverse transcriptase (RT)-like protein (PfRT). …
- NAID 130004054048
- 逆転写酵素阻害薬,プロテアーゼ阻害薬 (特集 抗ウイルス薬) -- (抗ウイルス薬の特性と適応・使い分け)
Related Links
- Nucleoside reverse transcriptase inhibitors (NRTIs) A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug ...
- What are Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)? When HIV infects a CD4 cell in a person's body, it copies its own genetic code into the cell's DNA. In this way, the cell is then "programmed" to create new ...
★リンクテーブル★
[★]
- 関
- adversely、backward、converse、conversely、inverse、inversely、opposite、oppositely、retro、reversal
[★]
- 関
- blocker、depressant、suppressant
[★]
- 関
- DNA-dependent RNA polymerase、DNA-directed RNA polymerase、RNA polymerase