WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the 13th letter of the Roman alphabet (同)m
the imperial dynasty of China from 1368 to 1644 (同)Ming dynasty

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Development of a Highly Potent, Novel M5 Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).

Gentry PR1, Kokubo M, Bridges TM, Noetzel MJ, Cho HP, Lamsal A, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR.
Journal of medicinal chemistry.J Med Chem.2014 Sep 3. [Epub ahead of print]
A functional high throughput screen identified a novel chemotype for the positive allosteric modulation (PAM) of the muscarinic acetylcholine receptor (mAChR) subtype 5 (M5). Application of rapid analog, iterative parallel synthesis efficiently optimized M5 potency to arrive at the most potent M5 PA
PMID 25147929

Effects of ovarian hormone treatment on the gene expression of muscarinic acetylcholine receptors in the ovariectomized rat myometrium.

Yasuda K1, Sumi G2, Kanamori C2, Nakajima T2, Tsuzuki T3, Cho H3, Nishigaki A3, Okada H3, Kanzaki H3.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2014 Sep;143:81-9. doi: 10.1016/j.jsbmb.2014.02.012. Epub 2014 Feb 28.
We investigate the effects of ovarian hormone on the gene expression of muscarinic acetylcholine receptors (M1-M5) in the myometrium using real-time PCR and evaluate the relationships between their expression and that of ovarian hormone receptors (ERα, ERβ, and PgR). Wistar rats were sham operated
PMID 24583025

SAR Studies on Carboxylic Acid Series M1 Selective Positive Allosteric Modulators (PAMs).

Kuduk SD, Beshore DC1.
Current topics in medicinal chemistry.Curr Top Med Chem.2014 Aug 26. [Epub ahead of print]
There is mounting evidence from preclinical and early proof-of-concept studies suggesting that selective modulation of the M1 muscarinic receptor is efficacious in cognitive models of Alzheimer's disease (AD). A number of non-selective M1 muscarinic agonists have previously shown positive effects on
PMID 25176125

Functional expression of M3, a muscarinic acetylcholine receptor subtype, in taste bud cells of mouse fungiform papillae

Eguchi Kohgaku,Ohtubo Yoshitaka,Yoshii Kiyonori
Chemical Senses 33(1), 47-55, 2008-01-01
… We investigated the functional expression of muscarinic acetylcholine receptor (mAChR) subtypes, M1-M5, in mouse fungiform TBCs. …
NAID 120002441102

Calcium Mobilization by Activation of M_3/M_5 Muscarinic Receptors in the Human Retinoblastoma

Kim Dae-Ran,Rah Sang Hoon,Sohn Joon Hyung [他],YEH Byung-Il,KO Chang Mann,PARK Jeong Sook,KIM Min-Jeong,LEE Joong Woo,KONG In Deok
Journal of pharmacological sciences 105(2), 184-192, 2007-10-20
… Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. … U-73122 (1 μM), a PLC inhibitor, and xestospongin C (2 μM), an IP3-receptor antagonist, elicited 11.5 ± 2.9% and 17.8 ± 1.9% suppressions, respectively. … Moreover, both M3 and M5 mAChRs were prominent in quantitative real-time-PCR. …
NAID 10024316345