WordNet

cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue" (同)alter, modify
become different in some particular way, without permanently losing ones or its former characteristics or essence; "her mood changes in accordance with the weather"; "The supermarkets selection of vegetables varies according to the season" (同)alter, vary
exchange or replace with another, usually of the same kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert centimeters into inches"; "convert holdings into shares" (同)exchange, commute, convert
a relational difference between states; especially between states before and after some event; "he attributed the change to their marriage"
change clothes; put on different clothes; "Change before you go to the opera"
coins of small denomination regarded collectively; "he had a pocketful of change"
money received in return for its equivalent in a larger denomination or a different currency; "he got change for a twenty and used it to pay the taxi driver"
remove or replace the coverings of; "Father had to learn how to change the baby"; "After each guest we changed the bed linens"
the balance of money received when the amount you tender is greater than the amount due; "I paid with a twenty and pocketed the change"
the result of alteration or modification; "there were marked changes in the lining of the lungs"; "there had been no change in the mountains"
undergo a change; become different in essence; losing ones or its original nature; "She changed completely as she grew older"; "The weather changed last night"
a different or fresh set of clothes; "she brought a change in her overnight bag"
a thing that is different; "he inspected several changes before selecting one"
the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election"
an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago" (同)alteration, modification
made or become different in some respect; "hes an altered (or changed) man since his election to Congress"
changed in constitution or structure or composition by metamorphism; "metamorphic rocks"
made or become different in nature or form; "changed attitudes"; "changed styles of dress"; "a greatly changed country after the war"
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
a British imperial capacity measure (liquid or dry) equal to 1/60th fluid dram or 0.059194 cubic centimeters
a United States liquid unit equal to 1/60 fluidram
the least possible; "needed to enforce minimal standards"; "her grades were minimal"; "minimum wage"; "a minimal charge for the service" (同)minimum

PrepTutorEJDIC

(…に)…'を'『変える』,改める《+『名』+『into』+『名』》 / …'を'『取り替える』,交換する / 〈小切手・為替〉'を'現金にする,〈金〉'を'両替えする;(…に)…'を'両替する《+『名』+『into』+『名』》 / (…に)『変わる』,変化する《+『to』(『into』)+『名』》 / (他の衣服に)着替える《+『into』+『名』》 / (…に)乗り換える《+『to』+『名』》 / 〈C〉(…の)『変化』,移り変わり,変遷《+『of』+『名』》 / 〈C〉(…の)『取り替え』,交換;乗り換え《+『of』+『名』》 / 〈U〉釣り銭,小銭
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
ミニム(液量の最小単位) / 《英》二分音符(《米》half note)
最小の,極小の,最近の

UpToDate Contents

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1. 成人における微小変化群の治療 treatment of minimal change disease in adults
2. 成人における微小変化群の病因、臨床的特徴、および診断 etiology clinical features and diagnosis of minimal change disease in adults
3. 微小変化群やその他のネフローゼ症候群における急性腎障害（急性腎不全） acute kidney injury acute renal failure in minimal change disease and other forms of nephrotic syndrome
4. 小児におけるネフローゼ症候群の病因、臨床症状、および診断 etiology clinical manifestations and diagnosis of nephrotic syndrome in children
5. 微小変化群の亜型：メサンギウム増殖、IgM腎症、C1q腎症 minimal change variants mesangial proliferation igm nephropathy c1q nephropathy

English Journal

Prospective 5-year follow-up of cyclosporine treatment in children with steroid-resistant nephrosis.

Hamasaki Y, Yoshikawa N, Nakazato H, Sasaki S, Iijima K, Nakanishi K, Matsuyama T, Ishikura K, Ito S, Kaneko T, Honda M; for Japanese Study Group of Renal Disease in Children.SourceDepartment of Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan, yuhamasaki@med.toho-u.ac.jp.
Pediatric nephrology (Berlin, Germany).Pediatr Nephrol.2013 May;28(5):765-71. doi: 10.1007/s00467-012-2393-4. Epub 2013 Jan 13.
BACKGROUND: Cyclosporine has improved remission rates in children with steroid-resistant nephrotic syndrome (SRNS). However, little prospective long-term follow-up data is available.METHODS: We prospectively followed and analyzed 5-year outcomes of all 35 patients enrolled in our previous prospectiv
PMID 23314441

Tacrolimus is an alternative therapy option for the treatment of adult steroid-resistant nephrotic syndrome: a prospective, multicenter clinical trial.

Fan L, Liu Q, Liao Y, Li Z, Ji Y, Yang Z, Chen J, Fu J, Zhang J, Kong Y, Fu P, Lou T, Liu Z, Yu X, Chen W.SourceDepartment of Nephrology, The First Affiliated Hospital, Key Laboratory of Nephrology, Ministry of Health of China, Sun Yat-sen University, 58# Zhongshan Road II, Guangzhou, 510080, China.
International urology and nephrology.Int Urol Nephrol.2013 Apr;45(2):459-68. doi: 10.1007/s11255-012-0205-1. Epub 2012 Jun 9.
BACKGROUND: The optimal therapy for adult steroid-resistant nephrotic syndrome (SRNS) remains a therapeutic challenge. We investigated the efficacy and safety of tacrolimus as a promising regimen in Chinese adult patients.METHODS: A prospective, multicenter trial was conducted in 9 nephrology center
PMID 22684795

Two new families with hereditary minimal change disease.

Chehade H, Cachat F, Girardin E, Rotman S, Correia AJ, Fellmann F, Bonny O.AbstractBACKGROUND: Steroid-sensitive idiopathic nephrotic syndrome (SSINS) is most often encountered in sporadic cases of minimal change disease (MCD). Only rare cases of familial forms of MCD have been reported and most of them only in one generation. The scarcity of data has precluded unraveling the underlying genetic defect and candidate gene approaches have been unsuccessful. Here we report two families with related SSINS cases and review the related literature.
BMC nephrology.BMC Nephrol.2013 Mar 22;14(1):65. [Epub ahead of print]
BACKGROUND: Steroid-sensitive idiopathic nephrotic syndrome (SSINS) is most often encountered in sporadic cases of minimal change disease (MCD). Only rare cases of familial forms of MCD have been reported and most of them only in one generation. The scarcity of data has precluded unraveling the unde
PMID 23517548