出典: meddic


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「beta blocker (trade name Lopressor) used in treating hypertension and angina and arrhythmia and acute myocardial infarction; has adverse side effects (depression and exacerbation of congestive heart failure etc.)」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/03 21:54:11」(JST)

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  • Assessing the reliability of uptake and elimination kinetics modelling approaches for estimating bioconcentration factors in the freshwater invertebrate, Gammarus pulex.
  • Miller TH1, McEneff GL2, Stott LC3, Owen SF4, Bury NR3, Barron LP5.
  • The Science of the total environment.Sci Total Environ.2016 Mar 15;547:396-404. doi: 10.1016/j.scitotenv.2015.12.145. Epub 2016 Jan 12.
  • This study considers whether the current standard toxicokinetic methods are an accurate and applicable assessment of xenobiotic exposure in an aquatic freshwater invertebrate. An in vivo exposure examined the uptake and elimination kinetics for eight pharmaceutical compounds in the amphipod crustace
  • PMID 26789375
  • Micropollutant removal in an algal treatment system fed with source separated wastewater streams.
  • de Wilt A1, Butkovskyi A2, Tuantet K3, Leal LH4, Fernandes TV5, Langenhoff A3, Zeeman G3.
  • Journal of hazardous materials.J Hazard Mater.2016 Mar 5;304:84-92. doi: 10.1016/j.jhazmat.2015.10.033. Epub 2015 Oct 20.
  • Micropollutant removal in an algal treatment system fed with source separated wastewater streams was studied. Batch experiments with the microalgae Chlorella sorokiniana grown on urine, anaerobically treated black water and synthetic urine were performed to assess the removal of six spiked pharmaceu
  • PMID 26546707
  • Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.
  • Gong Y1, Wang Z2, Beitelshees AL2, McDonough CW2, Langaee TY2, Hall K2, Schmidt SO2, Curry RW Jr2, Gums JG2, Bailey KR2, Boerwinkle E2, Chapman AB2, Turner ST2, Cooper-DeHoff RM2, Johnson JA2.
  • Hypertension.Hypertension.2016 Mar;67(3):556-63. doi: 10.1161/HYPERTENSIONAHA.115.06345. Epub 2016 Jan 4.
  • African Americans suffer a higher prevalence of hypertension compared with other racial/ethnic groups. In this study, we performed a pharmacogenomic genome-wide association study of blood pressure (BP) response to β-blockers in African Americans with uncomplicated hypertension. Genome-wide meta-ana
  • PMID 26729753
  • Super-fine powdered activated carbon (SPAC) for efficient removal of micropollutants from wastewater treatment plant effluent.
  • Bonvin F1, Jost L2, Randin L2, Bonvin E3, Kohn T2.
  • Water research.Water Res.2016 Mar 1;90:90-9. doi: 10.1016/j.watres.2015.12.001. Epub 2015 Dec 10.
  • In an effort to mitigate the discharge of micropollutants to surface waters, adsorption of micropollutants onto powdered activated carbon (PAC) after conventional wastewater treatment has been identified as a promising technology for enhanced removal of pharmaceuticals and pesticides from wastewater
  • PMID 26724443


  • Variability of Bioavailability and Intestinal Absorption Mechanisms of Metoprolol
  • FUKAO Miki,ISHIDA Kazuya,HORIE Asuka,TAGUCHI Masato,NOZAWA Takashi,INOUE Hiroshi,HASHIMOTO Yukiya
  • Drug Metabolism and Pharmacokinetics 29(2), 162-167, 2014
  • …   We previously reported that aging and/or cytochrome P450 2D6 polymorphism are responsible for the interindividual variability in the systemic clearance (CL) and bioavailability (F) of metoprolol. … The aim of the present study was to evaluate the residual variability of F of metoprolol in routinely treated Japanese patients and to investigate the intestinal absorption mechanism of the drug using human intestinal epithelial LS180 cells. …
  • NAID 130004463366
  • 経口メチルセルロース/アルギン酸液剤の物性に及ぼす薬物の影響
  • 下山 哲哉,浦木 睦,高橋 彩,小林 正拓,高畑 雅臣,牧野 陽佑,伊藤 邦彦,小林 道也
  • 薬剤学 74(1), 73-83, 2014
  • … The present study aimed to determine how the addition of drugs (acetaminophen, mexiletine, metoprolol, ambroxol, loxoprofen, theophylline, ketotifen and salbutamol) affects the rheological and in vitro drug release characteristics of a 2% methylcellulose formulation and of a 2% methylcellulose/0.5% alginate formulation. …
  • NAID 130003398001
  • Tokunaga Jun,Sato Shinichi,Kanbayashi Takashi [他],Imanishi Aya,Sagawa Yohei,Sato Masatoshi,Sakai Noriaki,Nishino Seiji,Shimizu Tetsuo
  • 秋田医学 40(2), 89-103, 2013-11-21
  • … Autonomic blockade with atropine, metoprolol, and dual atropine/metoprolol blockade (2 mg/kg) at postnatal day (P) 4 and P12 demonstrated predominantly sympathetic effects on baseline HR. …
  • NAID 110009658221
  • マウスの実験的動脈硬化に対する3種類のβアドレナリン受容体遮断薬 (プロプラノロール, メトプロロール, カルベジロール) の効果
  • 島田 佳奈,平野 絵美,木村 剛,岸本 千晴
  • Shinzo 45(5), 519-526, 2013
  •  目的 : アポリポプロテインE (アポE) ノックアウトマウスに対して, βアドレナリン受容体遮断薬 (β遮断薬) であるプロプラノロール, メトプロロール, カルベジロールの投与を行い, 動脈硬化に対する効果を検討した.  方法 : 実験的動脈硬化症は, アポEノックアウトマウスに高脂肪食を与えて作成した. 高脂肪食開始と同時の6週の時点で, 飲料水中にプロプラノロール (30mg/kg/日) …
  • NAID 130004688783


Before taking metoprolol, tell your doctor and pharmacist if you are allergic to metoprolol, acebutolol (Sectral), atenolol (Tenormin, in Tenoretic), betaxolol, bisoprolol (Zebeta, in Ziac), carvedilol (Coreg, Coreg CR), esmolol ...
Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about side effects, interactions and indications. ... Metoprolol side effects Get emergency medical help if you have any signs of an allergic ...
Learn more about metoprolol (Lopressor, Toprol XL), a drug to treat high blood pressure, heart pain, abnormal rhythms of the heart, and some neurological conditions. Information includes a description, generic and brand ...



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シプセロンセレクナートセロケンゼグミューラーメデピンメトプリックメルコモンロプレソールLopressor, Toprol-XL

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